Human immunodeficiency virus 1
Modification of a loop sequence between α helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV 1) derivative that has simian immunodeficiency virus (SIVmac239) vifand CA α helices 4 and 5 loop improves replication in cynomolgus monkey cells
... adapted virus has not yet been fully characterized; so it may be that fur- ther modifications of the viral genome are necessary for optimal replication of HIV-1 genomes in OWM ...incoming virus by ...
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RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.
... Although cis-acting sequences at several locations in the HIV-1 genome may contribute to packaging (9, 30, 32, 33, 43), we elected to focus primarily on the 206-base region spanning nucleotides 632 to 837 of ...
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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... became infected when the same dose of plasma that resulted in i.r. infection was used. The animals were monitored for ap- proximately 8 months to confirm their negative status. To de- termine if the addition of infected ...
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Biochemical Analyses of the Interactions between Human Immunodeficiency Virus Type 1 Vpr and p6Gag
... a dose-dependent fashion, with complex dissociation again be- ing very rapid (Fig. 6A). Within a single experiment, the bind- ing measurements were highly reproducible (compare the overlaid triplicates in Fig. 6A), ...
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Simian-Human Immunodeficiency Virus Containing a Human Immunodeficiency Virus Type 1 Subtype-E Envelope Gene: Persistent Infection, CD4+ T-Cell Depletion, and Mucosal Membrane Transmission in Macaques
... T-lymphotropic virus; these animals are housed at the California Regional Pri- mate Research Center, Davis, in accordance with American Association for Accreditation of Laboratory Animal Care ...cell-free ...
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A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.
... chimeric virus expressing patient isolate HIV-1 envelope glycoproteins will be valuable as a challenge virus for evaluating HIV-1 envelope-based vaccines and for exploring the genetic ...
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Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein
... a virus-specific immune ...simian immunodeficiency virus from tan- talus monkeys (SIVtan), feline immunodeficiency virus (FIV), and Ebola virus; the Nef protein of SIV; and the ...
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Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.
... of human immunodeficiency virus type 1 (HIV-1) binds to members of a family of proteins known as cyclophilins (CyPs) (29), which are expressed in all organisms from bacteria to primates ...
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Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4+ T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer
... Simian/human immunodeficiency virus (SHIV)- infected rhesus monkeys have proven particularly useful for these studies, since they allow the in vivo evaluation in higher primates of immune responses ...
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Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses
... restricted virus enters the ...of human tripartite motif proteins, some of which restricted HIV-1 infection but allowed normal levels of circle ...
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Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection
... Immunoblot analysis. To examine whether viruses incorporate Vpr at com- parable levels, similar amounts of each virus preparation (with the same RT activity) were lysed in Laemmli buffer and viral proteins were ...
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Lentivirus-Specific Cytotoxic T-Lymphocyte Responses Are Rapidly Lost in Thymectomized Cats Infected with Feline Immunodeficiency Virus
... example, immunodeficiency-causing lentiviruses, such as human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and feline immuno- deficiency ...
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Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120
... support of a robust and effective antibody response that arises early in HIV, SIV, and SHIV infections and contributes to the control of virus replication (1, 2, 7, 10, 13, 38, 46, 70; D. D. Richman, T. ...
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Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine
... the virus envelope ...AIDS virus. The vaccine was composed of recombinant human immunodeficiency virus type 1 (HIV-1) gp120, NefTat fusion protein, and simian ...
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Mutation of the Dominant Endocytosis Motif in Human Immunodeficiency Virus Type 1 gp41 Can Complement Matrix Mutations without Increasing Env Incorporation
... If a specific interaction between MA and Env was not es- sential for glycoprotein incorporation in the absence of endo- cytosis, then increasing the availability of glycoprotein on the surface of cells expressing MA ...
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Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy.
... The HIV-1 promoter used in this study contained an almost complete U3 region. However, deletions in HIV-2 U3 result in promoters with lower basal levels of transcription that still remain responsive to Tat (9). ...
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Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus
... factors modulating the infectiousness of HIV-1 in genital fluids may play a key role in the efficacy of sexual trans- mission of HIV-1 [6-8]. Multiple studies reported that semen boosts HIV-1 ...
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Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells.
... Epitope mapping of monoclonal antibodies against human immunodeficiency virus type 1 structural proteins by using peptides.. Monoclonal antibodies directed against human immunodeficiency[r] ...
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Mapping and Characterization of the N-Terminal I Domain of Human Immunodeficiency Virus Type 1 Pr55Gag
... dues. To examine the importance of these residues in the function of the I domain, R380 and R384 were mutated to alanine either singly or together. The double mutant was con- structed in the context of both the minimal I ...
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African Green Monkey TRIM5α Restriction in Simian Immunodeficiency Virus-Specific Rhesus Macaque Effector CD4 T Cells Enhances Their Survival and Antiviral Function
... strong virus-specific CD4 T-cell response has been closely corre- lated with less pathogenic disease outcomes and elite control in HIV-infected individuals (53, ...stabilized human TRIM5␣ in replication ...
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