Human immunodeficiency virus type 1
Biochemical Analyses of the Interactions between Human Immunodeficiency Virus Type 1 Vpr and p6Gag
... Human immunodeficiency virus type 1 (HIV-1) encodes a 97-amino-acid accessory protein called Vpr (an initialism for viral protein ...simian immunodeficiency virus ...
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In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat
... It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar ...
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Human Immunodeficiency Virus Type 1 Vectors Efficiently Transduce Human Hematopoietic Stem Cells
... leukemia virus (MuLV), cannot complete a repli- cative cycle in nondividing cells because the preintegration complex is unable to traverse the intact nuclear membrane (23, ...However, human ...
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In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
... Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type 1 tat proteins occurs in the absen[r] ...
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Modification of a loop sequence between α helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV 1) derivative that has simian immunodeficiency virus (SIVmac239) vifand CA α helices 4 and 5 loop improves replication in cynomolgus monkey cells
... Human immunodeficiency virus type 1 (HIV-1) produc- tively infects only humans and chimpanzees but not Old World monkeys (OWM) such as cynomolgus (CM) and rhesus (Rh) monkeys ...
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Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection
... Human immunodeficiency virus type 1 (HIV-1), the etiolog- ical agent of AIDS, infects and ultimately incapacitates critical cellular components of the immune ...
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Mutation of the Dominant Endocytosis Motif in Human Immunodeficiency Virus Type 1 gp41 Can Complement Matrix Mutations without Increasing Env Incorporation
... The human immunodeficiency virus type 1 transmembrane glycoprotein (TM) is efficiently endocytosed in a clathrin-dependent ...in virus particles, we examined whether perturbation ...
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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... The hallmark changes of CD4 ⫹ T-cell depletion and activa- tion of CD8 ⫹ T cells, as seen in humans, were not observed in these animals infected with SIVcpz or with coinfections of SIVcpz and HIV-1. A minor and ...
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RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.
... a type of noncanonical base interaction that occurs exclusively in purine- rich (and, especially, in G-rich) strands (6, 36, 46, 50); in support of this model, some groups have reported that one specific ...
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Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques
... M, 0.1 l Platinum Taq High Fidelity DNA polymerase (Invitrogen), and 1 l template DNA. The primers were envB5out and envB3out for 1st-round PCR and envB5in and envB3in for the 2nd round (43). The cycler ...
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Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4+ T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer
... toxic T-lymphocyte (CTL) function is dependent on their ac- tivity (19, 27, 31, 33), they secrete antiviral cytokines, and they have sometimes been shown to have antiviral cytotoxic effector function (4). Yet, because of ...
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Effects of Mutations in the G Tract of the Human Immunodeficiency Virus Type 1 Polypurine Tract on Virus Replication and RNase H Cleavage
... The crystal structure of HIV-1 RT in complex with a DNA- RNA template/primer whose sequence is derived from the PPT has provided valuable insight into features of the PPT and RT that are important for RNase H ...
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Mapping and Characterization of the N-Terminal I Domain of Human Immunodeficiency Virus Type 1 Pr55Gag
... using SDS-PAGE. It should be noted that the gradients shown are representative of at least two independent experiments. 55GAG/GFP produced particles with a peak density of 1.17 g/ml (Fig. 2A), consistent with an earlier ...
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Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses
... and human or simian TRIM5 ␣ molecules is dependent on an arginine at CA 110 (4, 25, 35, ...restricts human immunodeficiency virus type 1 (HIV-1) and contributes to the ...
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Lentivirus-Specific Cytotoxic T-Lymphocyte Responses Are Rapidly Lost in Thymectomized Cats Infected with Feline Immunodeficiency Virus
... example, immunodeficiency-causing lentiviruses, such as human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and feline immuno- ...
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HIV 1 Vif and APOBEC3G: Multiple roads to one goal
... of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of ...
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Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine
... the virus envelope ...provide type-specific sterilizing immunity, but in most cases do not confer protection against divergent ...AIDS virus. The vaccine was composed of recombinant human ...
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Simian foamy virus type 1 is a retrovirus which encodes a transcriptional transactivator.
... Certain oncoviruses, such as human T-lymphotropic virus type 1 HTLV-1, and certain lentiviruses, such as human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus, enc[r] ...
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Equine Tetherin Blocks Retrovirus Release and Its Activity Is Antagonized by Equine Infectious Anemia Virus Envelope Protein
... by type I and II interferon (IFN) treat- ment ...a virus-specific immune ...simian immunodeficiency virus from tan- talus monkeys (SIVtan), feline immunodeficiency virus (FIV), ...
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Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120
... simian/human immunodeficiency virus (SHIV) has provided a model system not only for evaluation of vaccines and antiviral therapies (6) but for studies of HIV infection and persistence as well, pro- ...
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