human indoleamine 2,3-dioxygenase
Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF-κB Pathways: Impairment in T Cell Functions
... Epstein-Barr virus (EBV) infection has been observed in tumor-infiltrated macrophages, but its infection effects on macrophage immune functions are poorly understood. Here, we showed that some macrophages in the tumor ...
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Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells
... Biotec GmbH, Germany). Isolated T-cells were counted by optical microscopy on a Neubauer plaque. Cell viability was assessed by trypan blue assay (Sigma-Aldrich; Merck Millipore, Germany). T-cells were cultured for 72h ...
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Mesenchymal stem cells inhibited the differentiation of MDSCs via COX2/PGE2 in experimental sialadenitis
... Cyclooxygenase 2; IDO: Indoleamine 2,3-dioxygenase; IFN: Interferon; iNOS: Inducible nitric oxide synthase; GRO: Growth-regulated oncogenes; MDSCs: Myeloid-derived suppressor cells; M-MDSCs: ...
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Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... ECs are one of the main cellular components of the innate immune system, which provide primary protection against airborne pathogens and allergens. Previous studies have shown that ECs can directly regulate conventional ...
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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells
... RosetteSep Human CD3 Depletion Cocktail kit (StemCell Technologies ...and 2 × 106 purified CD3+T cells and 200 U/ml human recombinant IL-2 (R&D Sys- tems) were ...every 2-3 ...
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Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts
... enzyme indoleamine 2,3- dioxygenase (IDO1) is the first and rate-limiting step of this pathway and is highly induced by the pro-inflamma- tory cytokine interferon (IFN)-g ...While human fibroblasts ...
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Targeting the indoleamine 2,3-dioxygenase pathway in cancer
... Contrary to these findings, Lob et al reported that D-1MT may not be an effective therapeutic option based on a study in a subset of human DCs [72]. Fol- lowing treatment of interferon-γ-treated mature DCs with ...
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Lavender oil suppresses indoleamine 2,3 dioxygenase activity in human PBMC
... Importantly, immune activation and inflammation are strongly associated with an increase of mood disorders [11,12]. Several biochemical links between psychoneuro- immunology and neuropsychopharmacology have been ...
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Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders
... verted to N-formylkynurenine by either indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) and is the first rate limiting step. N-formylkynure- nine is then converted by a series of ...
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Expression and regulation of immune modulatory enzyme Indoleamine 2,3 dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally ...
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Regulation of indoleamine 2,3-dioxygenase in primary human saphenous vein endothelial cells
... Notes: human saphenous vein endothelial cells (hsVecs) were transfected with pcDna3.1-egFP and signal was detected up to 6 days after transfection. hsVecs were then transiently transfected with psMaRT2g-IDO. ...
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Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1 in juvenile diabetes
... Restoration of Trp catabolism by tocilizumab in PBMCs from T1D patients. Tocilizumab (TCZ; Actemra, RoActemra) is a humanized mAb specific for human IL-6R that is currently approved for adult rheu- matoid ...
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The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection
... of human infection that has yielded critical insights into the immunobiology of leishmaniasis ...in 3 clinical forms; visceral leishmaniasis (VL), cutaneous leishmania- sis (CL) and mucocutaneous ...
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B7 costimulation and intracellular indoleamine 2,3 dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non pregnant women
... anti- human IDO monoclonal antibody (Millipore, USA) for 30 min at 4°C in the ...Figure 2 represents the measurement of intracellular IDO expression by flow ...
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Brain indoleamine 2,3 dioxygenase contributes to the comorbidity of pain and depression
... from human subjects suggests an apparent relationship between IDO expression/enzyme activity and clinical symptoms of pain and depression, but this cross-sectional clinical observation does not explore the causal ...
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Original Article Expression and function analysis of indoleamine 2 and 3-dioxygenase in bladder urothelial carcinoma
... Previous study showed that the IDO mRNA lev- els were relatively low in normal bladder tis- sues and IDO-positive cells were mostly found in the muscularis layer of bladders [21]. Thus, positive expression of IDO was ...
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Original Article Overexpressed indoleamine 2, 3-dioxygenase induced T cell apoptosis via Fas/FasL and Bcl-2/Bax-related apoptotic pathways in metastatic breast cancer
... and diseases of the immune system [21]. The ligand of Fas, FasL regulates lymphocyte inter- actions, and constitutive FasL expression by certain human and mouse malignant cells may contribute to immune evasion. ...
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Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies
... IDO: Indoleamine 2,3-dioxygenase; INV: Investigator; irAEs: Immune-related adverse events; JAK: Janus kinases; LAG-3: Lymphocyte-activation gene 3; MANAs: Mutation- associated neoantigens; ...
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New emerging targets in cancer immunotherapy: the role of LAG3
... Further concepts of clinical trials testing other anti-LAG3 regimen were introduced at the latest large oncological congresses, and the data is expected to be published within the next few years. Table 2 ...
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Search | Preprints
... lowered synthesis of neurotoxic and excitotoxic TRYCATs and thus play a role in clinical improvement or remission. For example, the drug 1-methyltryptophan can inhibit IDO and has been successful in reducing depressive ...
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