human leptin
Human Leptin Protein Induces Proliferation of A549 Cells via Inhibition of PKR Like ER Kinase and Activating Transcription Factor 6 Mediated Apoptosis
... Fig. 4. Detection of three UPR pathway proteins. (A) Detection of IRE1, p-Perk and cleaved ATF6. Statistical analysis of p-Perk (B), IRE1 (C) and Cleaved ATF6 (D). The average gray value of each preparation was ...
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Genetic and Environmental Influences on Human Cord Blood Leptin Concentration
... purified human leptin and both the standard and tracer are prepared with human ...for human leptin is 100 ...of leptin were added to five human serum samples, and the ...
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Evaluation of the leptin receptor in human spermatozoa
... for leptin receptor detection To assess leptin receptor expression in sperm and PBMCs, 10 6 cells were diluted in 200 μl of PBS contain- ing 1% BSA and left for 30 minutes at room tempera- ...
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FOSL2 promotes leptin gene expression in human and mouse adipocytes
... the human leptin ...the human LEP gene, in part because we are ultimately interested in the application of transcriptional regulation in humans to facilitate future ...the human LEP promoter ...
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Molecular characterization of adipose tissue in the African elephant (Loxodonta africana)
... of leptin mRNA in African elephant AT with actin used to confirm cDNA integrity (Figure ...the leptin transcript, which demonstrated ,90% similarity with the respective human homologue ...elephant ...
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Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?
... and human leptin sys- tem are not specifically adapted to a cereal-based diet, and that leptin resistance associated with diseases of affluence [32-38] could indicate insufficient adaptation to such ...
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New advances in the treatment of generalized lipodystrophy: role of metreleptin
... methionyl human leptin or metreleptin is a synthetic leptin analog that has been trialed in patients with leptin-deficient conditions, such as leptin deficiency due to mutations in the ...
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Leptin and the leptin receptor : Molecular and genetic studies
... that leptin levels increase throughout puberty, in response to increasing fat mass (Clayton et ...boys, leptin appears to increase until Tanner stage 2 of puberty when the testosterone surge occurs, ...
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Association Analysis of the Leptin and Ghrelin Receptor Gene Polymorphism in the Human with BMI
... of Leptin and Ghrelin receptor gene polymorphism in the population. Leptin is a product of obese (ob) gene expression that plays a role in energy metabolism and body ...The human leptin gene ...
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D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stability
... of human leptin, P41159, was used as an input protein ...of human leptin was built by comparing three available 3D modelling servers, including RaptorX, a web portal for 3D generating tertiary ...
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Monogenic forms of childhood obesity due to mutations in the leptin gene
... congenital leptin deficiency when they show impaired satiety, intense hyperphagia, and food-seeking behavior (see Clinical phenotype of pa- tients with congenital leptin deficiency) ...congenital ...
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... Subjects’ ages were obtained in anamnesis, while BMI was calculated from the weight and height obtained using a weight scale. FSH level was measured in the third day of menstruation; pre- ovulation estradiol level was ...
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Circulating omentin concentration increases after weight loss
... in human epicardial fat ...in human subcutaneous and omental adipocytes, trigger- ing Akt signaling in both the absence and presence of insulin ...BMI, leptin, waist circumference, fasting ...
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Phocid seal leptin : tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution
... of leptin divergence since these groups of pinnipeds ...of leptin sequence divergence have recently been reported in beavers, pikas, marmosets and heterothermic ...
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Leptin inhibits 4 aminopyridine– and pentylenetetrazole induced seizures and AMPAR mediated synaptic transmission in rodents
... Neocortical seizure model. Four- to six-week-old male Sprague-Dawley rats were anesthetized with halothane (4%) and then placed on a stereotaxic frame (David Kopf Instruments). A burr hole was drilled over the left hemi- ...
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The role of QRFP & GPR103 in human prostate cancer
... It has been shown that in functional assays, exposure of prostate cancer cells to QRFP increased cell migration, invasion and apoptosis in a dependent dose-time manner. Human Phospho-Kinase showed a variation in ...
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The Expression of Adiponectin Receptors and the Effects of Adiponectin and Leptin on Airway Smooth Muscle Cells
... Asthma and obesity are growing public health problems. Epidemiological data as well as data from animal models implicate obesity as an im- portant risk factor for asthma and atopic disease. In this study, we studied the ...
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Increased expression of the leptin receptor in human ovaries affected by endometrioma and detection of high levels of leptin in the ovarian endometriomal fluid
... of leptin in the PF than did patients with “deep” OEs ...PF leptin concentrations than patients with no implant, and the presence of OE had no significant main effect on leptin concentration [18]; ...
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Effect of Plasma-leptin on Cardiac Disorders with Type 2 Diabetes-patients
... plasma leptin (PL) levels shared by the brain revealed a 600% increase in over-mass people compared with healthy ...the leptin levels in healthy males are 935±32 ng/ml in obese-males against 160±59 ng/ml in ...
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Alterations of leptin in the course of inflammation and severe sepsis
... for leptin were supplied from SABiosciences ...of leptin mRNA expres- sion was calculated as follows: The expression of leptin mRNA relative to the housekeeping gene GAPDH in sam- ples from cells ...
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