Human myeloid leukemia cells
Involvement of CD11b integrin in the alteration of metabolic factors after phorbol ester stimulation of human myeloid leukemia cells
... pMTH1-U937 cells as compared to asCD11b-U937 cells (Figure ...pMTH1-U937 cells following TPA exposure (Figure ...asCD11b-U937 cells, respectively (Figure ...of human myeloid ...
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Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes
... Previous studies have demonstrated that ionizing radiation induces the expression of certain cytokines, such as TNF alpha/cachectin. However, there is presently no available information regarding the molecular mechanisms ...
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Transcriptional regulation of c jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells
... treatment. Moreover, the half-life of c-jun transcripts in ara-C-treated KG-1 cells was 42 min. These findings suggest that the increase in c-jun mRNA observed during ara-C treatment is regulated by a ...
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Retinoic acid Inhibition of the clonal growth of human myeloid leukemia cells
... of myeloid leukemia ...myeloblastic leukemia, and the HL-60, acute promyelocytic leukemia, human cell ...KG-1 cells were extremely sensitive to retinoic acid, with 50% of the ...
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Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells
... AML cells at 24 and 48 ...apoptotic cells. The migration and invasion abilities of HL-60 and HEL cells in the PDIA3 siRNA group were significantly suppressed compared with those in the control and ...
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Original Article The anti-leukemic effects of Obacunone (OCE) by inducing apoptosis via mitochondria-mediated pathway
... in human chronic my- eloid leukemia cells and explore its potential ...THP-1 cells were evaluated by MTT assay. Cells were treated with OCE at the concentrations of 10, 20 and 40 μM for ...
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IGF-IR determines the fates of BCR/ABL leukemia
... in human CML ...− cells infected by retroviral BCR-ABL-IRES-GFP were used to induce ...of leukemia by BCR/ ...IGF-IR cells had similar GFP + cells at 3 months (Figure 2B), suggesting ...
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The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
... of leukemia cells, We first confirmed that, in contrast to AML cell line OCI-AML3 naturally carrying NPM1-mA [25], the AML cell lines KG-1a, HL60, K562 and THP-1 lacked NPM1-mA expression (Figure ...THP-1 ...
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Original Article Curcumol induced apoptosis of human acute myeloid leukemia KG-1a cells
... on human acute myeloid leukemia KG-1a ...killed cells and its ...acute myeloid leuke- mia KG-1a cells, which provided a theoretical and experimental basis for the clinical ...
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Tumor necrosis factor downregulates granulocyte colony stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes
... patients with AML in serum-free medium with TNF (10(3) U/ml), and subsequent binding studies using 125I-G-CSF reveal that TNF downregulates the numbers of G-CSF receptors by approximately 70%. G-CSF receptor numbers on ...
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Linker histone epitopes are hidden by in situ higher-order chromatin structure
... the human myeloid leukemia cell line HL-60/ S4 in ...permeabilized cells are sonicated to nucleosome-size fragments, prior to incu- bation with antibody and ...meabilized cells are ...
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Comparative analysis of targeting key genes in stat pathway in k562 cells
... in human chronic myeloid leukemia cell line (K562) were evaluated through interference by respective ...K562 cells were analyzed and the proliferation inhibition and apoptosis induction were ...
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Original Article Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide
... APL cells in vitro and in vivo [34], and has been assessed in clinical studies for the treatment of AML ...cancer cells [39, ...leukemic cells drug ...of leukemia with multidrug resistant cell ...
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Development and Characterization of Tool Compounds Targeting the Runt Domain’s interaction With Cbfβ
... acute myeloid leukemia (AML) cell lines, and reduced the progenitor activity of mouse and human leukemia cells harboring the t(8;21), but not normal bone marrow ...and human T ...
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Long noncoding RNAs: pivotal regulators in acute myeloid leukemia
... Second, lncRNAs can bind protein partners to form a complex. For instance, a proposed mechanism for UCA1 action in proliferation regulation is to sequester hnRNP I, which is a positive translation regulator of p27 ...
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Abolished adherence alters signaling pathways in phorbol ester-induced human U937 cells
... single cells in normal culture dishes exhibited both, a cell-to-cell and a cell-to-matrix ...dead cells after 72 h (data not ...dead cells after TPA exposure, however, this accumulation of cell death ...
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Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
... A number of different mechanisms may underlie ac- quired drug resistance in CSC/LSC. One is genetic in- stability and the ‘mutation capacity’ of the malignant genome, resulting in a plethora of mutations in critical ...
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The Philadelphia chromosome in leukemogenesis
... Ph-positive leukemia, including CML and ...CML cells by the PI3K-AKT-mTOR pathway ...CML cells [104, ...mutant cells in vivo and in vitro ...-transformed cells, ...
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Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11)
... is a fusion translocation. To date, more than 30 different PDGFRB fusion partners have been identified [2, 3], with the majority of them only occurring in individual patients. Nonetheless, a few of these fusions - for ...
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Landscape of gene fusions in epithelial cancers: seq and ye shall find
... The first gene fusions to be defined in solid cancers, RET/PTC [15] and NTRK1 [16] rearrangements in papil- lary thyroid carcinoma were identified through a “trans- formation assay” using cancer genomic DNA transfected ...
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