Human myocardium
Metabolic fate of extracted glucose in normal human myocardium
... Glucose is an important substrate for myocardial metabolism. This study was designed to determine the effect of circulating metabolic substrates on myocardial glucose extraction and to determine the metabolic fate of ...
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Human Myocardium Releases Heat Shock Protein 27 (HSP27) after Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 through Toll-like Receptor (TLR)-2 and TLR4
... that human myocardium releases HSP27 after global I/R associated with cardiac sur- gery and that extracellular HSP27 con- tributes to the mechanism underlying postischemic myocardial inflammatory response ...
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In vivo estimation of passive biomechanical properties of human myocardium
... of myocardium was evident from the simple shear test of pig ’ s [9] and human myocardium ...passive myocardium under simple shear ...pig myocardium [9] to define fully orthotropic ...
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Genomic selection of reference genes for real-time PCR in human myocardium
... non-failed human myocardium, however, the number of genes used needs to be a balance between accuracy and practical ...in human myocardium (SRP14 and TPT1 for analysis within failed or ...
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Identification of a satellite fatty acid ethyl ester synthase from human myocardium as a glutathione S transferase
... chromatographed with GSH S-transferase on DEAE cellulose, Sephadex G-100 and S- hexylglutathione agarose, and also displayed GSH S-transferase activity in catalyzing the conjugation of GSH with nitrobenzene-containing ...
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Pharmacological and ischemic preconditioning of the human myocardium: mitoKATP channels are upstream and p38MAPK is downstream of PKC
... Our results have shown that activation of p38MAPK is a crucial step in the transduction pathway of precondition- ing in the human myocardium. Activation of p38MAPK has also been connected to preconditioning ...
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Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study
... Despite a recognized potential for clinical application, there is an identified lack of standardization and trans- ferability of T1 mapping methods beyond a single and commonly expert center. Setups of available T1 ...
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Quantification of [11C]-meta-hydroxyephedrine uptake in human myocardium
... the myocardium and the blood at later time points, together with high liver uptake, will require im- proved reconstruction methods and/or scatter correction algorithms before an image-derived input function can be ...
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HDAC4 controls histone methylation in response to elevated cardiac load
... on human myocardium that comprehensively analyzes histone modifications in the promoter regions of genes that are activated during cardiac remodeling in patients with heart fail- ure, ...in human ...
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Diminished post rest potentiation of contractile force in human dilated cardiomyopathy Functional evidence for alterations in intracellular Ca2+ handling
... Myocardial tissue. Experiments were performed in isolated, electri- cally driven left ventricular trabeculae from human myocardium. The preparations were obtained from a total of 12 nonfailing hearts which ...
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Intracellular sodium and contractile dysfunction in left ventricular hypertrophy
... in myocardium, Koch-Weser and Blinks (1963) introduced the abstract terms of positive and negative inotropic effects of ...ventricular myocardium from humans and most animal species demonstrates a positive ...
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Protective responses in the ischemic myocardium
... the human myocardium may become irre- versible within an hour, although there is clinical ben- efit to restoring blood flow even after longer periods of total coronary ...
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Effect of the degree of ischaemic injury and reoxygenation time on the type of myocardial cell death in man: role of caspases
... the human myocardium during the first 8 hours of reoxygenation, so that apoptosis is more important than necrosis when the ischaemic period is ≤ 90 minutes but the reverse is true after 180 minutes of ...
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Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues
... female human myocardium facilitates the anti-proliferative effects of progesterone on cardiac fibroblasts through the E2- dependent increase of the responsiveness of these cells to progesterone; hence E2 ...
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Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
... of human induced pluripotent stem (iPS) cells [3,4], which can be used for disease modeling and drug toxicity ...Additionally, human iPS cells can be continu- ously expanded in culture in an undiff ...
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Isozymic changes in myosin of human atrial myocardium induced by overload Immunohistochemical study using monoclonal antibodies
... either human atrial (HC alpha) or ventricular (HC beta) myosin was performed to clarify the distribution of each isozyme in normal as well as pressure-overloaded human ...normal human ventricles, all ...
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Effect of autologous mesenchymal stem cells induced by low level laser therapy on cardiogenesis in the infarcted area following myocardial infarction in rats
... The effect of photobiostimulation on stem cells or pro- genitor cells has not been extensively studied. LLLT ap- plication to normal human neural progenitor cells signi- ficantly increases ATP production in these ...
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Differential expression of myosin heavy chain isoforms in cardiac segments of gnathostome vertebrates and its evolutionary implications
... the myocardium, while the pan-MyHC antibody A4.1025 labels the myocardium of the inflow (sinus venosus and atrium) but not the outflow (ventricle and conus arteriosus) cardiac segments, as opposed to other ...
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Molecular Basis of Human CD36 Gene Mutations
... A marked feature of the CD36 gene is the presence of several (at least five) al- ternative and independent first exons and their promoters, which lack TATA- boxes and CpG islands (21). Another al- ternative promoter and ...
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Magnetocardiography capabilities in myocardium injuries diagnosis
... ischemic myocardium damage, IHD course prognosis, determining of indications for preventive “aggressive” therapy and estimation of its efficacy in patients with ...
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