human pluripotent stem cells
Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells
... from human pluripotent stem cells ...hPSC-NMP cells with bFGF, TGFβ1, and Chir99021 for 4-5 days (whereupon they expressed paraxial mesoderm-specific transcription factors) and then ...
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Targeted Proteomics of Human Pluripotent Stem Cells
... Human pluripotent stem cells (hPSCs) exhibit two unique characteristics: pluripotency and self-renewal. These properties are maintained by a series of complex signaling pathways, however, ...
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Challenges and strategies for generating therapeutic patient specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells
... 2005), human CDX function remains technically difficult to study, since CDX expression is restricted to embryonic ...in human acute leukemias with both normal karyotypes or t(9;11) MLL fusions (Bansal et ...
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BMP4 directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
... identified human pluripotent stem cells (hPSCs), including embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), as useful models for trophoblast differentiation; ...
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells
... Schwann cells; iPSC: Induced pluripotent stem cells; hESCs: Human embryonic stem cells; NCSCs: Neural crest stem cells; hPSCs: Human ...
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Pluripotent stem cells for Parkinson's disease: progress and challenges
... of human pluripotent stem cells (hPSCs) make them a promising alternative cell source for cell replacement therapy for ...these cells into PD animal models have demonstrated survival, ...
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Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
... to human neurons, the complexity of the molecular mecha- nisms underlying HD pathology, and the lack of ad- equate animal ...for human pluripotent stem cells (PSCs), have jointly ...
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Pluripotent human stem cells: Standing on the shoulders of giants
... these cells became paramount. To this end, the International Stem Cell Initiative (ISCI) was founded in 2004 as a consortium of researchers from around the world, funded by the International Stem ...
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Standardization of human stem cell pluripotency using bioinformatics
... Human pluripotent stem cells are promising tools to advance the study of cell differentiation and embryonic ...These cells hold promise for the develop- ment of personalized ...
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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
... by stem cells have been demonstrated to show similar therapeutic effects on ischemic ...mesenchymal stem cell-derived exosomes could activate the PI3K/Akt pathway to enhance myocardial viability and ...
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Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro
... glial cells that are essential for the generation of the myelin sheath around the axonal processes in the mammalian central nervous system [1, ...precursor cells (OPCs) pass through multiple developmental ...
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Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives
... heart cells in a fi- brin matrix, attached to flexible posts [94], and engineered three-dimensional muscle strips and cardiac organoid chambers with key characteristics of cardiac physiology have been examined to ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Epidemiological research has revealed that ED is becoming increasingly common among men and affected more than 300 million people in 2015 [2]. The erectile function of the penis requires the coordinated function of both ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... Overall, we have shown that the current platform enables quantitative prediction of the potential cardio- toxicity of drugs at different time points by analyzing the changes of CI, beating rate, and amplitude of ...
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Implementation of experimental cellular (cellular-genetic) therapies on the example of eye diseases
... Induced Pluripotent Stem Cells (IPSC) by Shinya Yamanak's team, which ended with the 2012 Nobel Prize ...used stem cells in the therapy of cellular visual diseases are two types of PSC ...
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OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal epithelial transition
... fully pluripotent state has gained significant interest. Human iRSCs might represent a suitable cell source for directed conversion without full reprogramming, and for dissecting the molecular mechanisms ...
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Establishment of porcine and human expanded potential stem cells
... potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation 1 ...like cells in vitro. Under similar conditions, ...
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Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells
... Using the Lipofectamine-Plus reagent (Life Technologies), pMXs-green fluorescent protein (GFP), pMXs-OCT4, pMXs-SOX2, pMXs-KLF, and pMXs-c-MYC were trans- fected into prepared PLAT-GP cells (2.5 × 10 4 ...
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Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
... especially stem cells including embryonic stem cells (ESC), neural stem/precursor cells (NSC/NPC), mesenchymal stem cells (MSC), and induced pluripotent ...
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Scalable Generation of Mesenchymal Stem Cells from Human Embryonic Stem Cells in 3D
... pluripotent stem cells (iPSC) are unlimited and stable sources with the potential to differentiate into any cell type in the ...OP9 cells, sorting, scraping or handpicking of cells ...
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