human pluripotent stem cells (hPSCs)
Targeted Proteomics of Human Pluripotent Stem Cells
... Human pluripotent stem cells (hPSCs) exhibit two unique characteristics: pluripotency and self-renewal. These properties are maintained by a series of complex signaling pathways, however, ...
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Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells
... from human pluripotent stem cells ...hPSC-NMP cells with bFGF, TGFβ1, and Chir99021 for 4-5 days (whereupon they expressed paraxial mesoderm-specific transcription factors) and then ...
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells
... Human pluripotent [embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)] [4, 5] and multi- potent stem cells from adipose [6, 7], bone ...
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BMP4 directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
... identified human pluripotent stem cells (hPSCs), including embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), as useful models for trophoblast differentiation; ...
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Pluripotent stem cells for Parkinson's disease: progress and challenges
... of human pluripotent stem cells (hPSCs) make them a promising alternative cell source for cell replacement therapy for ...these cells into PD animal models have demonstrated survival, ...
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Challenges and strategies for generating therapeutic patient specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells
... 2005), human CDX function remains technically difficult to study, since CDX expression is restricted to embryonic ...in human acute leukemias with both normal karyotypes or t(9;11) MLL fusions (Bansal et ...
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Pluripotent human stem cells: Standing on the shoulders of giants
... these cells became paramount. To this end, the International Stem Cell Initiative (ISCI) was founded in 2004 as a consortium of researchers from around the world, funded by the International Stem ...
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Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
... to human neurons, the complexity of the molecular mecha- nisms underlying HD pathology, and the lack of ad- equate animal ...for human pluripotent stem cells (PSCs), have jointly ...
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3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
... the human brain makes it difficult to detect all pathological conditions of neuro- logical disorders in ...immune cells, or even blood-brain barrier within organoids would be beneficial for their advanced ...
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Standardization of human stem cell pluripotency using bioinformatics
... Regardless of the source of variation, better methods are needed to assess pluripotency and the differentiation potential of human pluripotent stem cells. These methods will be particularly ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Epidemiological research has revealed that ED is becoming increasingly common among men and affected more than 300 million people in 2015 [2]. The erectile function of the penis requires the coordinated function of both ...
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Making gametes from pluripotent stem cells – a promising role for very small embryonic-like stem cells
... spherical cells could be isolated by OSE scraping of postmenopausal and women with pre-mature ovarian ...OSE cells from adult rabbits, monkey, sheep and peri-menopausal women (who are otherwise devoid of ...
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Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
... nodal cells derived from healthy and LQT1 individuals ...of stem cell differentiation (or direct cardiac reprogramming from fibroblasts [153]) towards cardiac lineage and screening of factors to enhance ...
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OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal epithelial transition
... 2A). Pluripotent marker genes, TDGF1 and REX1 were repressed, whereas NANOG and endogenous SOX2 were ...TIG1 cells and iPSCs ...TIG1 cells, and iRSCs and iPSCs ...the pluripotent marker ...
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Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro
... glial cells that are essential for the generation of the myelin sheath around the axonal processes in the mammalian central nervous system [1, ...precursor cells (OPCs) pass through multiple developmental ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... Overall, we have shown that the current platform enables quantitative prediction of the potential cardio- toxicity of drugs at different time points by analyzing the changes of CI, beating rate, and amplitude of ...
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Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives
... differentiating cells can be maintained in medium containing basic fibro- blast growth factor, Dickkopf homolog 1, and vascular endothelial growth factor to support further cardiac lineage development ...neg ...
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Implementation of experimental cellular (cellular-genetic) therapies on the example of eye diseases
... Induced Pluripotent Stem Cells (IPSC) by Shinya Yamanak's team, which ended with the 2012 Nobel Prize ...used stem cells in the therapy of cellular visual diseases are two types of PSC ...
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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
... on human ESC-Qualified BD Matrigel (BD Biosciences, Franklin Lakes, NJ, USA) in mTESR1 (StemCell Technologies, Vancouver, BC, Canada) ...the cells were cultured for 14 ...These cells were then ...
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Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
... especially stem cells including embryonic stem cells (ESC), neural stem/precursor cells (NSC/NPC), mesenchymal stem cells (MSC), and induced pluripotent ...
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