human recombinant interleukin-2
Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2
... The immunologic consequences of prolonged infusions of rIL-2 in doses that produce physiologic serum concentrations of this cytokine were investigated. rIL-2 in doses of 0.5- 6.0 x 10(6) U/m2 per d (3.3-40 ...
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Cloning and Expression of Recombinant Human Interleukin-7 in Chinese Hamster Ovary (CHO) Cells
... (ELISA) Recombinant human IL-7 secreted into the medium was measured by indirect ...for 2 hours at room temperature, the plates were incubated with mouse anti-hIL-7 monoclonal antibody (1:400; Santa ...
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Recombinant interleukin 2 and gamma interferon act synergistically on distinct steps of in vitro terminal human B cell maturation
... of recombinant interleukin 2 (IL-2) on the in vitro differentiation of human tonsillar B cells which were not preincubated with Staphylococcus aureus Cowan I or with anti- human ...
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Effect of recombinant human interleukin-7 on Pseudomonas aeruginosa wound infection
... I nterleukin-7 (IL-7) is a central cytokine of the immune system, which plays an important role in the modulation of T- and B-cell development and T-cell homeostasis [1, 2]. The potential and wide range of its ...
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Validation of biological activity testing procedure of recombinant human interleukin-7
... (Table 2) are indicative of ac ceptable level of conformity between experimental data and OD results calculated using linear regres sion equation for test samples of recombinant human ...
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Original Article Effect of human recombinant interleukin-10 on cytokines in adjuvant arthritis rat
... Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease that mainly causes sys- temic small arthropathy [1]. Its clinical feature is progressive and symmetric joint destruction, then causing joint swelling, ...
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Development of the method for microbiological purity testing of recombinant human interleukin-7-based product
... binant human IL-7 by “microbiological purity” parameter and development of its measurement method with consideration of the requirements of guideline documents regarding quality of medicinal pro ...
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas Soriano RA *1 and Gonzalez M 2
... Oprelvekin, recombinant human interleukin-11, a thrombopoietic growth factor, in patients afflicted with chemotherapy-induced thrombocytopenia (platelet count<50,000 ...phase 2 trial were ...
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Multiple biological activities of human recombinant interleukin 1
... for human monocyte interleukin 1 (IL-1), pI 7 form, was expressed in Escherichia ...the recombinant protein. Homogeneous human recombinant IL-1 (hrIL-1) was tested in several assays to ...
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Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease
... of interleukin-5 is restricted to eosinophils, it should be an ideal target to block this response in the lungs of allergic animal models of asthma, and has been studied in several ...to interleukin-5 ...
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Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
... production, as well as cell surface and soluble forms of IL-2R. IL-2R gene expression was inhibited for at least 72 h after exposure of cells to dexamethasone. In the presence of exogenous IL-2, dexamethasone ...
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A common polymorphic allele of the LH beta-subunit gene is associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology
... together, these data raise the question of whether v-betaLH assessment of all patients should be employed prior to ovarian stimulation, or whether one should await the results of the first stimulated cycle. Following ...
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... and -13 and that increased expression of IL-1Ra can reduce the activity of MMP-1, -3, -7 and -13 in tissue explants [6], we investigated the effect of TNF-α stimulation on expression of MMPs from each of these groups and ...
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Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro.
... IL-2 is a potent trigger for viral replication. This is observed in vitro and is suggested by studies of HIV-infected patients given IL-2 (30, 33). The finding that in four persons with the highest CD4 1 ...
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Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... Two-dimensional Hierarchical cluster analysis of expres- sion patterns in SF of the four studied cytokines was per- formed (Figure 2). Four principal clusters of patients were identified and also a high ...
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Interleukin 2 and interleukin 2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
... The production of IL-1 and IL-6 by pituitary cells has recently been demonstrated. In this study we investigated the expression of IL-2 and its receptor (IL-2R) by pituitary cells of different species. In Northern ...
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Human eosinophils express functional interleukin 2 receptors
... of human eosinophils to respond to IL-2. IL-2 was a potent chemoattractant with ED50 of 10(-12) M with eosinophils from all normal and eosinophilic donors ...
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Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1 Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163 171
... natural human interleukin (IL-1)1 beta and human recombinant (hrIL)-1 alpha and beta are potent stimulators of HA production by fibroblasts in ...
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Administration in vivo of recombinant interleukin 2 protects mice against septic death
... Administration in vivo of recombinant interleukin 2 (rIL-2) to mice induces a polyclonal IgM response. When co-administered with a specific antigen, rIL-2 can enhance concentrations of ...
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IL-15 as a potential target in leukemia
... tion of peripheral mononuclear cells of infected patients. In these patients, an elevation of IL-15 mRNA was also detected. This phenomenon was also confirmed in another study, where an increase of IL-15R α , IL-15 mRNA ...
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