Human replication protein A
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication
... the replication cycle, or it may simply be due to the limit of detection of this event by Western blotting with these particular ...viral protein expression and occurs while RNA genome replication is ...
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pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication
... viral replication (14, ...specific protein interaction of pUL69aa1-146 with PRMT6 which could be detected both by yeast two-hybrid and coimmunopre- cipitation ...
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Differential Requirement of Human Cytomegalovirus UL112-113 Protein Isoforms for Viral Replication
... and replication compartments within the nucleus (18–20) and interact with IE2 and the viral DNA polymerase processivity factor pUL44 ...DNA replication was confirmed by genetic studies demonstrating that ...
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Human Papillomavirus Type 18 E1 Protein Is Translated from Polycistronic mRNA by a Discontinuous Scanning Mechanism
... in protein or mRNA structure, stabil- ity, and compartmentalization and other mechanisms, includ- ing translational ...cation protein E1 from human papillomavirus type 6 (HPV6), HPV11, and HPV18 into ...
9
Cell-Specific Modulation of Papovavirus Replication by Tumor Suppressor Protein p53
... p53 protein on the activity of different ...of human p53 on the CMV promoter in the mouse cell line NIH ...multifunctional protein, the apparent reduction in reporter expression could be caused by ...
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Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation
... the replication of HIV-1 NL4-3 in HLT more severely than a change to Met found in all SIVcpz- Ptt strains (Figure ...poor replication potential in HLTs nor coding differences at Gag30 can explain the ...
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Repression of HMGA2 Gene Expression by Human Cytomegalovirus Involves the IE2 86-Kilodalton Protein and Is Necessary for Efficient Viral Replication and Inhibition of Cyclin A Transcription
... and protein and inhibits virus ...86 protein (48), and the HCMV recombinant virus CR208, which lacks exon 4 of the MIE gene and thus produces no IE1 72 protein (24, ...
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Identification and Functional Characterization of Phosphorylation Sites of the Human Papillomavirus 31 E8^E2 Protein
... E2 protein regulates transcription, replication, and nuclear retention of viral ...modulate protein stability, DNA-binding activity, and chromo- somal ...E8^E2 protein shares the hinge domain ...
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Human Cytomegalovirus UL36 Protein Is Dispensable for Viral Replication in Cultured Cells
... UL36 protein, one encodes the UL37 protein, and another is bicistronic, producing both the UL38 protein and a polypeptide comprising the first exon of the UL37 coding region when translated in vitro ...
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Human Phosphate Binding Protein inhibits HIV 1 gene transcription and replication
... in human plasma while performing structural studies on another target, the HDL-associated human paraoxonase hPON1 ...sequenced human genome ...
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Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1
... HBV replication significantly upregulated the expres- sion of SIRT1 in ...HBV replication, we first examined the mRNA and protein levels of SIRT1 in a panel of cell lines, includ- ing primary ...
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Human Parainfluenza Virus Type 2 V Protein Inhibits Genome Replication by Binding to the L Protein: Possible Role in Promoting Viral Fitness
... The human parainfluenza virus type 2 (hPIV2) V protein plays important roles in inhibiting the host interferon response and promoting virus growth, but its role in hPIV2 replication and transcription ...
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Cellular Topoisomerase I Modulates Origin Binding by Bovine Papillomavirus Type 1 E1
... In human PVs, the human chaperone proteins Hsp70 and Hsp40 independently and additively enhance origin bind- ing by E1 ...cellular protein stimulates origin recognition by a viral origin recognition ...
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Human Cytomegalovirus Tegument Protein ppUL35 Is Important for Viral Replication and Particle Formation
... At present, it is unclear how ppUL35 could be responsible for the translocation of ppUL82 and ppUL83 (pp65) from the nucleus to the cytoplasm. A similar phenotype has been de- scribed for a mutant of HCMV with a lack of ...
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Human Cytomegalovirus pUS24 Is a Virion Protein That Functions Very Early in the Replication Cycle
... of protein from virions, NIEPs, and DBs were analyzed by Western blotting after no treatment ( ⫺ ), trysin digestion (T), or trypsin digestion after disruption of particles with Triton X-100 ...
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Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis
... Currently, hMPV is the major causative agent of acute respira- tory disease in humans (1–5). Despite major efforts, there is no FDA-approved vaccine for hMPV. Similar to hRSV, inactivated vaccines are not suitable for ...
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Human Papillomavirus E2 Protein: Linking Replication, Transcription, and RNA Processing
... There is evidence that E2, in addition to having DNA-related roles, can bind RNA and has properties and functions similar to those of SRSF proteins. Like the serine-arginine domain in which phosphorylation controls the ...
5
Specific Sequence of a Beta Turn in Human La Protein May Contribute to Species Specificity of Hepatitis C Virus
... La protein is known to be an essential host factor for translation and replication of hepatitis C virus (HCV) ...of human La protein with the HCV internal ribosomal entry site (IRES) around ...
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The Cellular Protein SPT6 Is Required for Efficient Replication of Human Cytomegalovirus
... cellular protein SPT6 is important for UL69 func- tion ...virus replication, we incorporated the C496A, PP602/603AA, and E617A mutations into the viral genome to generate individual UL69 viral ...
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Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication
... HRV replication, we first infected HeLa cells with HRV16 and explored if PKD1 was activated by detecting both phosphorylation at S744/748 in the kinase activation loop and autophosphorylation at S916 at its C ...
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