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Human spermatogonial stem cells

Eliminating malignant contamination from therapeutic human spermatogonial stem cells

Eliminating malignant contamination from therapeutic human spermatogonial stem cells

... or cells (containing SSCs) before the gonadotoxic therapy and have these cells reintroduced into his testis after he is cured of his primary ...malignant cells. We created this scenario in this study ...

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Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes

Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes

... adipose-derived stem cell and bone mesenchymal stem cell transdifferentiation effi- ciency [55, 56]; therefore, OECCM includes the induction ...neural cells into DA neurons and maintain the phenotype ...

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Propagation of human germ stem cells in long-term culture

Propagation of human germ stem cells in long-term culture

... somatic cells was not ...these cells after 6 weeks and they could not support cluster of GSCs as feeder ...somatic cells as feeder layer by allo or autogenic references by non-enzymatic ...somatic ...

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PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells

PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells

... embryonic stem cells ...in human anaplastic thyroid carcinoma (HTC/3) and malignant glioma (U87) cells [17, 18], and improves targeting ability [17, ...

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Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice

Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice

... niche cells and remaining endogenous SSCs could explain why transplanting MSCs alone also resulted in a better spermatogenic recovery compared to non-transplanted ...xenografted human ovarian tissue ...

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Manipulation of spermatogonial stem cells in livestock species

Manipulation of spermatogonial stem cells in livestock species

... Sertoli cells to form seminiferous tubule structures in the testes of infertile recipients with busulfan-compro- mised or genetically defective endogenous Sertoli cells was reported ...Sertoli ...

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Enhancement in colonization of bovine spermatogonial stem cells following addition of knock-out serum replacement to culture medium

Enhancement in colonization of bovine spermatogonial stem cells following addition of knock-out serum replacement to culture medium

... germ cells prior to injection into recipient seminiferous tubules is of importance in spermatogonial stem cells (SSCs) ...and human embryonic stem ...as cells having been ...

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The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system

The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system

... and human SSCs ...marrow cells and exploration of factors that are associated with the regulation of their pro- liferation and differentiation [18, ...of cells generates reactive oxygen species ...

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Flenkenthaler, Florian
  

(2017):


	Secretome analysis of testicular peritubular cells as a clue for solving the puzzle of the human spermatogonial stem cell niche.


Dissertation, LMU München: Tierärztliche Fakultät

Flenkenthaler, Florian (2017): Secretome analysis of testicular peritubular cells as a clue for solving the puzzle of the human spermatogonial stem cell niche. Dissertation, LMU München: Tierärztliche Fakultät

... In human testis, TNF-α is released by macrophages and mast cells, which are located in the tubular wall close to the peritubular ...the human male genital ...germ cells of the ...peritubular ...

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Assessment of Nycodenz Gradient on Enrichment and Culture of Perinatal Porcine Spermatogonial Stem Cells

Assessment of Nycodenz Gradient on Enrichment and Culture of Perinatal Porcine Spermatogonial Stem Cells

... of spermatogonial stem cells into testes was expanded to larger animal species recipients including the monkey, bovine, rat, and human (Schlatt et ...the spermatogonial stem ...

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Effects of nano-selenium on mRNA expression of markers for spermatogonial stem cells in the testis of broiler breeder males

Effects of nano-selenium on mRNA expression of markers for spermatogonial stem cells in the testis of broiler breeder males

... Fertility is one of the most important parameters in breeder farms and cockerels play an outstanding role in the fertility of eggs in broiler breeder farms. Todays, supplementation of chicken diet with additives such as ...

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Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture

Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture

... The protein TEKT also contributes to cilia, flagella, basal bodies, and centrioles. In mammals, five TEKTs (TEKT1, 2, 3, 4, and 5) have been identified in testis and spermatozoa [9,10] . These proteins, except TEKT1, ...

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Stem Cells: A Step Ahead in Regenerative Dentistry with Accent on Orthodontics

Stem Cells: A Step Ahead in Regenerative Dentistry with Accent on Orthodontics

... 1. Repair of Alveolar Bone Defect: Orthodontic treatment warrants extraction of premolars for correction of malocclusion [18]. During extractions, accidentally buccal plates can be lost leading to alveolar bone defect. ...

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Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

... Spermatogonial stem cells (SSCs) capable of self-renewal and differentiation are the foundation for sper- ...with stem cell ...the stem cell state and revealed what we believe to be ...

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Genetic and epigenetic properties of mouse male germline stem cells during long term culture

Genetic and epigenetic properties of mouse male germline stem cells during long term culture

... cultured cells retained spermatogonial stem cell activity, we used a spermatogonial transplantation technique that allows competent spermatogonial stem cells to colonize ...

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Spermatogonial Stem Cells: A Review of Essential Factor for Self-Renewal and Differentiation

Spermatogonial Stem Cells: A Review of Essential Factor for Self-Renewal and Differentiation

... Introduction: Spermatogonial stem cells (SSCs) are considered as promising management for azoospermic patients who couldn’t obtain sperms from the epididymis or directly from testis on assisted ...

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Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis

Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis

... germ cells (Franca et ...germ-cell stem cells can initiate spermatogenesis, the ensuing differentiation results in improper cellular associations, highlighting the idea that RAR α function in the ...

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Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

... where cells having neuron-like morphology with specific genes and proteins expression like retinal precursors, and mature photoreceptors were formed by SHED differentiation in ...formed cells remained ...

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Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells

Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells

... feeder cells, and then subjected to FACS analysis to determine the percentage of SSCs and relative mRNA expression of the genes involved in SSC meiosis, differen- tiation, and ...AgNPs-treated cells than in ...

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Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture

Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture

... self-renewing spermatogonial stem cells (SSCs) in cell culture conditions, using zebrafish testicular hyperplasia cells that accumulate early stage ...feeder cells, they differentiated ...

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