Human thymus
Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus
... Our results suggest that while the laboratory-attenuated Lai/ IIIB virus had recovered the ability to replicate in vivo through passage in the infected laboratory worker, it had not regained corresponding pathogenic ...
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Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation
... the human thymus, when comparing the “Postnatal” group with the “Adult” ...aging thymus, the relative abundance of TEC is ...aging thymus, FOXN1 protein were not detected in epithelial ...in ...
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Thymic hyperplasia in patients with Graves' disease Identification of thyrotropin receptors in human thymus
... for human TSH receptor were AGAAATAGCCCCGAG- TCCCGTGGA (nucleotides 2 26– 2 3) and GGTTTCATTGCATAG- TCCCT (518–537) (19, ...normal human thymus cDNA (Clontech) was amplified in 100 m l of PCR buffer ...
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Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus
... thymocyte death occurring during the negative selection process we analyzed the cellular distribution of clusterin mRNA and protein by in situ hybridization and immunocytochemistry in the human thymus. We ...
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Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
... the human cortical stroma is in sharp contrast to the reported expression of Cat L in mouse thymus ...and human Cat V, and the results from the Cat L KO mice, we propose that, in humans, Cat V has ...
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Human thymus contains IFN α–producing CD11c–, myeloid CD11c+, and mature interdigitating dendritic cells
... the thymus contains precursor cells capable of giving rise to DCs and to T, B, and NK cells (16, 18, 19), we investigated in purified thymic DCs the expression of lymphoid-related ...
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Fusion-Induced Apoptosis Contributes to Thymocyte Depletion by a Pathogenic Human Immunodeficiency Virus Type 1 Envelope in the Human Thymus
... during human immunodeficiency virus type 1 (HIV-1) infection remain incompletely ...the human fetal-thymus organ culture ...HIV-1-infected thymus, correlated with induction of apoptosis in ...
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Growth hormone resurrects adult human thymus during HIV 1 infection
... In conditions of severe T cell depletion, such as HIV-1 infection, limited T cell production by the thymus can thwart the immune response, putting individuals at increased risk of infection with opportunistic ...
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Self antigen–presenting cells expressing diabetes associated autoantigens exist in both thymus and peripheral lymphoid organs
... the human thymus. We find that the human thymus harbors specialized cells synthesizing (pro)insulin, GAD, and IA-2, mainly localized in the medulla, and we demonstrate such cells also in ...
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Successful Transplantation of the Thymus in Nezelof's Syndrome
... A 6-month-old girl with congenital thymic dysplasia or Nezelof’s syndrome (lack of I cell function and normal levels of immunoglobulins) was given a transplant of a human thymus gland fr[r] ...
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Analysis of the adult thymus in reconstitution of T lymphocytes in HIV 1 infection
... the human thymus can be thought of as a chimeric organ composed of a peripheral lymphoid com- ponent (the perivascular space) and a central lymphoid component (the true epithelial thymus) ...
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Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model
... with human immune cells, resulting in the development of humanized murine spleen and lymph nodes (axillary and mesenteric lymph nodes), albeit the humanized murine lymphoid tissue development is suboptimal ...
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Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice A new model of myasthenia gravis
... the human thymus tissues are accepted as long-term grafts in the host SCID mice, with human lymphocytes, thymic stroma, and thymic myoid cells demonstrable in transplanted thymus for at least ...
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Hedgehog Signalling in the Embryonic Mouse Thymus
... Hedgehog signalling to DN thymocytes negatively regulates pre-TCR-induced differentiation to DP cell in both mouse and human [22,25,34]. The first evidence for this came from in vitro studies which demonstrated ...
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Video-Thoracoscopic Extended Thymectomy with Sternal Elevation and Carbon Dioxide Insufflation Fukai R *1 , Inoue T 2, Araki O3 , Shiono H 4and Watanabe K1
... residual thymus had been found in the neck after bilateral VATS thymectomy without a transcervical approach ...entire thymus including any found in the ...
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REGROWTH AND OVERGROWTH OF THE THYMUS AFTER ATROPHY INDUCED BY THE ORAL ADMINISTRATION OF ADRENOCORTICOSTEROIDS TO HUMAN INFANTS
... cum massive shrinkage of the cardio thymic image was observed radio graphically by us in seven infants, following the oral administration of adrenocortico steroids.' After stoppage of th[r] ...
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Decreased Thymus Size on Chest Radiography: A Sign of Pediatric Human Immunodeficiency Virus Infection?
... Decreased Thymus Size on Chest Radiography: A Sign of Pediatric Human. Services[r] ...
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Viral infection of the thymus.
... Our results show that i infection starts at the fetal stage and is maintained throughout adulthood, and ii this chronic infection of the thymus can be eliminated by transfer of virus-spe[r] ...
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CT density of cervical thymus, in comparison with mediastinal thymus
... the thymus is predominantly a mediastinal organ, part of it can often be seen in lower neck normally [1, ...cervical thymus has to be differentiated from pathologies like cervical lymph node, ...
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Human skin cells support thymus independent T cell development
... of human T cells. We report that fibroblasts and keratinocytes from human skin arrayed on a synthetic 3-dimensional matrix support the development of functional human T cells from hematopoietic ...
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