Hydrophobic residues
Reversible exposure of hydrophobic residues on albumin as a novel strategy for formulation of nanodelivery vehicles for taxanes
... of hydrophobic residues of a protein to a pH-induced partial unfolding: interaction between hydrophobic residues on the protein and the hydrophobic active pharmaceutical ingredient, and ...
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Dispersed and Conserved Hydrophobic Residues of HIV-1 Vif Are Essential for CBFβ Recruitment and A3G Suppression
... When HIV-1 Vif was first identified, its unusually high con- tent of W residues was recognized as a unique property (16, 19, 20). Interestingly, all the W residues in HIV-1 Vif are involved in A3 ...
9
PubMedCentral-PMC5584451.pdf
... served hydrophobic residues in the RPM1 CC domain, which presumably are important for proper structural conformation of the CC domain and the intermolecular interactions necessary for RIN4 ...
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Overlapping Roles of the Rous Sarcoma Virus Gag p10 Domain in Nuclear Export and Virion Core Morphology
... single hydrophobic-residue-to-alanine substitutions were analyzed for their subcellular localization and levels of VLP release by using Gag-GFP fusion ...four hydrophobic residues act in concert to ...
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A STUDY ON THE EFFECT OF CINNAMON AND CINNAMALDEHYDE ON BOVINE SERUM ALBUMIN (BSA) PROTEIN BY USING FT-RAMAN SPECTROSCOPY
... was 0.42 ± 0.02; there was no significant difference between the value for BSA alone and BSA + cinnamon sample (0.433 ± 0.081). In contrast, in sample BSA + cinnamaldehyde the tryptophan band intensity (0.296 ± 0.066) ...
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A Conserved Amphipathic Helix in the N-Terminal Regulatory Region of the Papillomavirus E1 Helicase Is Required for Efficient Viral DNA Replication
... conserved hydrophobic residues in the E1 AH, analogous to those in TAD2/VP16C that directly contact their target proteins, decreased transactivation activity and, importantly, also reduced by 50% the ...
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Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
... eight hydrophobic (8hmut) residues present in the three PMB have been eliminated and replaced with neutral alanines, in order to test the binding of PARs and the resulting modulation of hTop1 activity in ...
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Role of Nonstructural Protein NS2A in Flavivirus Assembly
... to hydrophobic residues Ser, Thr, and Tyr at codon 59 (groups 4 to 8) ...of hydrophobic residues at NS2A codon 59, pseudoreversions were introduced into the plasmid repPAC  ...a ...
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The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins.
... 181 residues of the NS3 nonstructural protein is responsible for cleavage at four sites (3/4A, 4A/4B, 4B/5A, and 5A/5B) in the nonstructural ...more hydrophobic residues in the NS4A central region ...
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Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk.
... of hydrophobic residues in CR6 severely impaired CBF1/RBPJk interaction and transactivation, while mutation of CR5 led to a moderate decrease in both ...tryptophan residues at positions 323 and 324 ...
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Loop B is a major structural component of the 5 HT3 receptor
... The residues are mostly located in the in- ner and outer b -sheets comprising the b -sandwich of the extracellular part of the subunit, and their side chains all point into the interior of the b -sandwich (see ...
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Strategy for Foaming Improvement of Whey Protein Concentrates by Addition of Hydroxypropylmethylcellulose and Heating: Relation with Interfacial Properties
... Time-dependent loss angle for mixed systems are plotted in Figures 4a-c. The adsorbed films could be attributed to the self-association of biopolymers molecules occurring at the air-water interface [31]. Self- ...
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Analysis of the Cullin Binding Sites of the E4orf6 Proteins of Human Adenovirus E3 Ubiquitin Ligases
... Our studies indicated that Ad12 and Ad40 E4orf6 products bind Cul2 via a cellular-like consensus Cul2 box domain: Ad12, 78YEMFILKKY86; Ad40, 79WEKHVCKIY87 (bold letters indi- cate consensus hydrophobic ...
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Using Structural Bioinformatics to Model and Design Membrane Proteins
... of residues to engage both αIIb and ...at residues neighboring the common conserved ...large, hydrophobic residues and a small glycine residue for interaction, while the more variable regions ...
235
Control of Aggregated Bacterial Communities through Engineered Surface Displayed Proteins
... The N-terminal cap design script uses four consecutive movers. In the first mover, FastDesign was used to fully redesign (e.g. allow residue identities in the N-terminal cap to change, allow the backbone to move, and ...
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In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (Pla2)
... The hydrophobic interactions produced a rigid protein structure which is difficult to denature by high ...mostly hydrophobic residues and for that reason, all three of the compounds formed ...
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Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
... and hydrophobic residues Phe381, Leu384, Met522, Tyr385, Trp387, Leu531, Leu352, Ala527 and Val523 in the active site (ii) a salt bridge formed between Arg120 and the carboxylate group of the inhibitor, and ...
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Atypical Fusion Peptide of Nelson Bay Virus Fusion-Associated Small Transmembrane Protein
... N-terminal hydrophobic domain (HD) that was hypothesized to function as a fusion ...slightly hydrophobic motif to identify possible structural requirements for fusion ...aliphatic residues were found ...
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Probing Novel Elements for Protein Splicing in the Yeast Vmal Protozyme: A Study of Replacement Mutagenesis and Intragenic Suppression
... Conserved hydrophobic residues are required for the reaction: The involvement of the conserved hydropho- bic triplet valine residues was established by isolation of mutan[r] ...
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Modeling the Structure of Yeast MATα1: An HMG Box Motif with a C Terminal Helical Extension
... intercalating hydrophobic residues of the first helix, and the hydrophobic residues required for interactions within the core of the protein are remarkably conserved in α-domains and HMG-box ...
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