hypoxia inducible factor
Original Article Specific silencing of hypoxia inducible factor-1α, hypoxia inducible factor-2α and hypoxia inducible factor-1β by small interference RNA reduces the expression of vascular endothelial growth factor in BGC-823 gastric cancer cells under hypoxia
... of hypoxia-inducible factor (HIF)-1α, HIF-2α and HIF-1β on vascular endothelial growth factor (VEGF) expression in BGC-823 gastric cancer cells under ...Methods: Hypoxia model was ...
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Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... Commercial aircraft pressurization can provide a “shirt-sleeve environment” within the cabin, with an equivalent altitude of 8,000 ft, while the aircraft can operate up to approximately 40,000 ft. In contrast, military ...
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Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
... escape. Hypoxia occurs during placenta and tumor development and was shown to activate ...combining hypoxia-mimicking treatment and 5-aza-2’deoxycytidine, a DNA demethylating agent used in anti-cancer ...
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Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
... HIF-1: hypoxia-inducible factor; ROS: reactive oxygen species; ARNT: aryl hydrocarbon receptor nuclear translocator; AhR: aryl hydrocarbon receptor; bHLH: basic helix loop helix; PAS: Per ARNT Sim; ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF), by the lining and stromal cells of the synovium in both ...Because hypoxia inducible factor (HIF)-1 α ...
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Original Article High altitude increases the expression of hypoxia-inducible factor 1α and inducible nitric oxide synthase with intest-inal mucosal barrier failure in rats
... hypobaric hypoxia related to the failure of intestinal mucosal ...of hypoxia-inducible factor 1α (HIF-1α), inducible nitric oxide synthase (iNOS) and morphological changes of intestinal ...
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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia inducible factor 1α
... is hypoxia-inducible factor 1 (HIF-1) (16, ...the hypoxia-inducible genes that contain functionally important HIF-1 binding sites are those encoding erythropoietin (16), transferrin ...
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Original Article 14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/ Akt/NF-кB signal transduction pathway
... of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor ...to hypoxia in our unpublished data as ...to hypoxia was ...
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Epithelial hypoxia inducible factor 1 is protective in murine experimental colitis
... and hypoxia at the tissue ...colonic hypoxia and its significance in the disease ...by hypoxia-inducible factor-1 (HIF-1), including intestinal trefoil factor (ITF), CD73, and ...
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Diacetoxyscirpenol as a new anticancer agent to target hypoxia- inducible factor 1
... activates hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis and by augmenting the ability of tumors to ...under hypoxia in cancer ...to ...
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Hypoxia Inducible Factor 1as a Diagnostic and Predictor Test of Liver Fibrosis
... criteria included, Hepatic tumors, or hepatic focal lesion, Vascular liver diseases or, portal, superior mesenteric, thrombosis, and unfit for US guided liver biopsy, all subjects had liver function tests, virology ...
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Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
... environment hypoxia had been ...of hypoxia-inducible factor. The hypoxia-inducible factor hydroxylase pathway regulates a massive transcriptional cascade that is operative ...
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Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... that hypoxia inducible factor 1α (HIF-1α) is a key transcription factor of hypoxia [2], serving important roles in the pathogenesis of HPH ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... growth factor receptor; ER α : estrogen receptor alpha; FBS: fetal bovine serum; Hc7: MCF-7 cells transfected with HER2 gene by the laboratory of ...growth factor receptor 2; HIF-1: hypoxia ...
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Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia inducible factor
... transcription factor hypoxia-inducible factor-1 (HIF-1) plays a critical role in promoting cellular responses to reduced oxygen levels (Jewell et ...a hypoxia-responsive α subunit and ...
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Studies of hypoxia response and regulation of hypoxia inducible factor HIF 1 in Caenorhabditis elegans
... However, the expression levels of the HIF-1-dependent reporter and HIF-1 target gene K10H10.2 are significantly higher in rhy-1 mutants than in vhl-1 mutants Chapter 3 Figure 5A & C, ind[r] ...
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Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function
... Whilst hypoxia and the HIF/hydroxylase pathway in the regulation of myeloid cell function and survival is of direct functional importance in regulation of innate immune responses, a role for HIF in the regulation ...
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Hypoxia inducible factor regulates hepcidin via erythropoietin induced erythropoiesis
... by hypoxia via increased erythro- poietin (EPO) synthesis in kidney and ...exporter. Hypoxia suppresses hepcidin, thereby enhancing intestinal iron uptake and release from internal ...to hypoxia, ...
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Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium
... ADP-ribosylation factor-like protein 13B (ARL-13b), was also found to be enriched in the chondro- cyte cilium (Figure 1B, green) in agreement with other studies using other cell types ...
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Surviving ischemia: adaptive responses mediated by hypoxia inducible factor 1
... These results do not address why individuals of simi- lar age and degree of coronary occlusion vary in the extent of collateralization. Peripheral blood mononu- clear cells isolated from patients with no angiographic ...
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