Hypoxia inducible factor (HIF)
Original Article 14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/ Akt/NF-кB signal transduction pathway
... of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor ...to hypoxia in our unpublished data as ...on ...
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Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... tissue hypoxia, which can induce up to a 1,000- fold increase in circulating serum EPO levels ...the hypoxia-mediated induc- tion of EPO identified the heterodimeric basic helix-loop-helix (bHLH) ...
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Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... hypobaric hypoxia alters the mRNA expression levels of hypoxia-inducible factor alpha (HIF-1α) and VEGF as well as VEGF pro- tein ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... course. Hypoxia inducible factor (HIF)-1α and HIF-2α are impor- tant transcription factors, regulating VEGF gene responses to hypoxic ...of HIF-αs, as occurs under hypoxic ...
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Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... with hypoxia-induced pulmonary hypertension ...HSP70, hypoxia-inducible factor 1α (HIF-1α), endothelin-1 (ET-1), and inducible nitric oxide synthase (iNOS) were measured at ...
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Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
... escape. Hypoxia occurs during placenta and tumor development and was shown to activate ...combining hypoxia-mimicking treatment and 5-aza-2’deoxycytidine, a DNA demethylating agent used in anti-cancer ...
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Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions
... The modulation of protein – protein interactions (PPIs) represents a major challenge in modern chemical biology. Current approaches (e.g. high-throughput screening, computer aided ligand design) are recognised as having ...
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Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
... environment hypoxia had been ...of hypoxia-inducible factor. The hypoxia-inducible factor hydroxylase pathway regulates a massive transcriptional cascade that is operative ...
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Studies of hypoxia response and regulation of hypoxia inducible factor HIF 1 in Caenorhabditis elegans
... However, the expression levels of the HIF-1-dependent reporter and HIF-1 target gene K10H10.2 are significantly higher in rhy-1 mutants than in vhl-1 mutants Chapter 3 Figure 5A & C, ind[r] ...
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Hypoxia-inducible factor (HIF) network: insights from mathematical models
... both HIF and NFκB seem to play important functions. HIF can have both pro-inflammatory and anti-inflammatory roles, dependent on the cell where it is expressed, while NFκB works primarily as regulator of ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... hypoxic HIF-1 α is inherently expressed in AI-resistant cells, upregulated by HER2-PI3K/Akt-mTOR pathway and is an important factor in letrozole-resistant breast cancer cells, regulating target genes such ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the expression ...
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Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... During hypoxia, tissues undergo a series of physiological responses to defend themselves against a low oxygen supply, including increased angiogenesis, erythropoiesis, and glucose ...of hypoxia are mainly ...
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Endothelial cell pseudopods and angiogenesis of breast cancer tumors
... of hypoxia inducible factor 1- α (HIF) reveals the subcortical area of the tumor to contain HIF positive cells while the tumor capsule, cortex and necrotic areas of the tumor ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
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Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1
... to hypoxia, cells respond by up- regulating a number of genes, mainly through the hypoxia- inducible factor (HIF) ...during hypoxia [21]. It has been reported that HIF-1α ...
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Endogenous Gene Regulation by DNA Binding Polyamides
... activators: hypoxia inducible factor 1 (HIF- 1) and androgen receptor ...the HIF-1-DNA and AR-DNA interfaces has relevance to human ...the hypoxia response element (HRE) binds ...
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Resveratrol Inhibits Hypoxia Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
... inhibited hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) via the PI3K/Akt ...or hypoxia for 16 ...the hypoxia-induced HIF-1α ...
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Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... growth factor (VEGF) plays a pivotal role in vascular changes in ...of hypoxia-inducible factor (HIF)-1α, VEGF, phosphatidylinositol-3 kinase (PI3K) and phosphorylated-Akt levels, and ...
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Study protocol: safety and efficacy of propranolol in newborns with Retinopathy of Prematurity (PROP-ROP): ISRCTN18523491
... retinal hypoxia, that increases the stability of inducible a subunit of the transcription factor hypoxia-inducible factor ...(HIF)-1. HIF-1a accumulation leads to ...
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