Hypoxic – Ischemic Brain Injury
The role of oxidative stress in perinatal hypoxic-ischemic brain injury
... hypoxicischemic brain injury particularly in preterm ...of brain injury and subsequent neurological abnormalities in infants with perinatal HIE, which might be prevented by antioxidative ...
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Neuroprotective Effect of Erythropoietin on Hypoxic-Ischemic Brain Injury in Neonatal Rats
... with hypoxic-ischemic brain ...immature brain from hypoxic-ischemic ...of hypoxic-ischemic brain injury in the new- born ...radical injury is ...
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Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest
... Secondary injury is a major determinant of outcome in hypoxic ischemic brain injury (HIBI) after cardiac arrest and may be mitigated by optimizing cerebral oxygen delivery (CDO 2 ...
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Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death
... Figure 1: Neuronal cell death pathways in the neonatal hypoxic-ischemic brain injury. a. Necroptosis-Ligation of tumour necrosis factor receptor 1 (TNFR1) results in the recruitment of ...
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Early MR Features of Hypoxic ischemic Brain Injury in Neonates with Periventricular Densities on Sonograms
... of hypoxic-ischemic brain injury in neonates with periventricular densities on sono- grams and to determine the added value of MR imaging as compared with sonography ...
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Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two hit” model
... Abstract Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in ...secondary brain injury and ...
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Original Article Neuroprotective and regenerative effects of melatonin on hypoxic-ischemic brain injury in neonatal rats
... blood- brain barrier to enter the brain but can also penetrate the hypothalamus barrier, reaching the central nervous system, where it can pro- tect against various neurodegenerative dise- ases and ...
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Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study
... an hypoxic-ischemic brain injury that selectively involved the neuronal population during early phases: this is a unique pic- ture, very different from the experimental studies in which a ...
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Grape Seed Proanthocyanidin Extract Adjusts NeuN/GFAP in a Murine Model of Neonatal Hypoxic-ischemic Brain Injury
... the brain. Previous studies have shown that when HIE injury occurs, it often leads to irreversible death of neurons in the brains of HIE mice, and large accumulation of astrocytes on the injured side can ...
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Hypoxic Ischemic Brain Injury
... MORE FAVORABLE OUTCOME – Watershed and Central Patterns Delayed Anoxic Leukoencephalopathy - usually 1-3 weeks after MR Diffusion & Spectroscopy - acute setting (neonates) 4-5 days F[r] ...
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Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury
... HI-induced brain injury and the expression of GLAST pro- ...HI-induced brain injury found in DEX-treated ...HI-induced brain injury by in- creasing GLT-1 ...
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Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats
... levels in hippocampus at 3-4 weeks old in rat brain tis- sue and hippocampus [16,40,41]. The roles of GLT1 in immature brain remained unclear. In human premature infant, expression of EAAT2 was observed in ...
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Excitatory Amino Acids Contribute to the Pathogenesis of Perinatal Hypoxic Ischemic Brain Injury
... A large body of experimental evidence indicates that over-activation of excitatory amino acid (EAA) receptors may mediate irreversible neuronal injury in a variety of [r] ...
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Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches
... neonatal hypoxic–ischemic pathophysiology, these studies have demonstrated the high potential of these antioxidants as efficient therapeutic agents for the reduction of brain damage in ...
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HYPOXIC-ISCHEMIC BRAIN INJURY of the NEWBORN & CEREBRAL PALSY. Jin S. Hahn, M.D.
... Prematurity and severe birth asphyxia are important risk factors for CP, but most children with CP did not experience either of these risk factors Mild or brief intrapartum asphyxia doe[r] ...
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Isoflurane Anesthesia Initiated at the Onset of Reperfusion Attenuates Oxidative and Hypoxic-Ischemic Brain Injury
... was supported with MV, the recovery of CBF has improved. This significantly augmented the neuroprotective effect of isoflurane in mice exposed to isoflurane for 15 minutes, and decreased infarct volume in mice ...
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Granulocyte Stimulating Factor Attenuates Hypoxic ischemic Brain Injury by Inhibiting Apoptosis in Neonatal Rats
... at multiple levels, 11 including inhibition of apoptosis, 6 modulation of inflammation, 3 and recruitment of endogenous stem cells. 7,8 In the present study, TUNEL staining was performed to detect nuclear DNA breakdown, ...
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Use of estetrol with other steroids for attenuation of neonatal hypoxic-ischemic brain injury: to combine or not to combine?
... Recent studies proved that the neuroprotective actions of estrogens also depend on their strong antioxidant specifications and positively correlate with the number Figure 4: MAP-2 staining of brain coronal ...
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Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic ischemic brain injury
... in brain injury from inflammation and edema occurs second- ary to inhibition of a specific caspase such as ICE (18), with subsequent decreases in the formation of IL-1 b ...H-I injury and that ...
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Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury
... neonatal brain injury, due to additional high energy demands of the immature brain as it develops [15], and protecting mitochondrial function represents a valid target for future therapeutic ...
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