IFN regulatory factor 4
The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL 6
... regulator IFN regulatory factor–4 (IRF4) in this ...a regulatory function in T cells, in a mouse model of IBD whereby colitis is induced in RAG-deficient mice by transplantation with ...
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In vivo alterations of IFN regulatory factor 1 and PIAS1 protein levels in cystic fibrosis epithelium
... of IFN-γ of 10, 25, and 100 units/mL, though the reported concentration of IFN-γ in airway epithelial lining fluid is estimated to be less than 2 units/mL ...er IFN-γ ...Higher IFN-γ ...
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Apoptosis Induced by Mammalian Reovirus Is Beta Interferon (IFN) Independent and Enhanced by IFN Regulatory Factor 3- and NF-κB-Dependent Expression of Noxa
... A second such molecule is the BH3-only protein Bid, which activates the mitochondrion-based apoptotic amplification loop following death receptor signaling (46). Bid is cleaved by activated caspase-8 to form tBid, which ...
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Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
... Fluorescence microscopy was used to localize infiltrating cells in the CNS. CD3+ T cells were increased in num- ber and more diffusely dispersed in white matter in the spinal cord of IRF7-deficient mice with EAE, ...
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Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population
... that IFN regulatory factor 5 (IRF5 [MIM 607218]) gene polymorphisms are significantly associated with systemic lupus erythemato- sus (SLE [MIM ...
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Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP
... the IFN-  reporter in the presence of in- creasing amounts of ...the IFN-  promoter ...SeV-induced IFN-  production and the activation of the NF- B promoter induced by SeV or TNF- ␣ ...the ...
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Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells
... 3; IFN: Interferon; IL1B: Interleukin 1 beta; IL6: Interleukin 6; IRF3: Interferon regulatory factor 3; ISRE: IFN-stimulated response elements; LPS: Gram-negative lipopolysaccharide; LTA: ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... the IFN system, interfer- ing either with IFN induction, IFN signaling, or the action of IFN-induced effector proteins (23, ...blocking IFN induction is a most efficient and widespread ...
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Defective CD4+CD25+regulatory T cell functioning in collagen induced arthritis: an important factor in pathogenesis, counter regulated by endogenous IFN γ
... 15 min with the Fc-receptor-blocking antibodies anti- CD16/anti-CD32 (CD16/CD32; BD Biosciences Pharmingen, San Diego, CA, USA). Cells were washed with PBS containing 2% FCS and stained with the indi- cated ...
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Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in Macrophages
... of IFN-␥-regulated ...of IFN- ␥ -regulated genes that depend on STAT-1 and IRF-1 but not on IRF-3, IRF-7, or CIITA for their ...with IFN- ␥ , using three independent biological ...(Fig. 4 and ...
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NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3
... Reverse transcriptase PCR (RT-PCR). RNA was isolated using an RNeasy minikit (Qiagen) as recommended by the manufacturer. RNA from infected cells was subjected to DNase I digestion and cDNA synthesis using a PrimeScript ...
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
... gene factor 3 (ISGF3) nuclear translocation by inducing importin ␣ 5 degradation ...␣ 4) and KPNA4 ((importin ␣ 3), leading to suppression of IRF3 and NF- B transcriptional activity and preventing the ...
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A Rhesus Rhadinovirus Viral Interferon (IFN) Regulatory Factor Is Virion Associated and Inhibits the Early IFN Antiviral Response
... creased IFN-␣ expression (16). Not only do KSHV vIRFs function to limit the IFN response, but they also play a significant role in modulation of the cell cycle and ...
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IFN regulatory factor–8 expression in macrophages governs an antimetastatic program
... It is now well recognized that metastasis arises from the primary tumor via intrinsic and extrinsic mech- anisms (4). Extrinsic mechanisms reflect the contribution of stromal and immune cells that infiltrate the ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... FIG 6 Rubicon inhibits dimerization of IRF3. (A) Control (Scramble) and Rubicon knockdown (sh-Rubicon) RAW264.7 cells were infected with PR8-GFP (MOI ⫽ 2) and harvested at the indicated times (0, 2, 4, 8, and 16 ...
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Original Article Modulation of the function of dendritic cells in adolescents with chronic HBV infection by IFN-λ1
... DCs are the most powerful APCs, the only cells to activate resting T lymphocytes discovered so far, they defense against viral infections through the secretion of IL-12, IFN-γ and other Thl cytokines as well as by ...
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Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication
... the IFN trans- gene product elicits an antiviral state following secretion into the culture ...to IFN- ␣/ applied to the culture supernatant of the transfected cells blocks the antiviral effect ...the ...
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A Regulatory Circuit Composed of a Transcription Factor, IscR, and a Regulatory RNA, RyhB, Controls Fe S Cluster Delivery
... ABSTRACT Fe-S clusters are cofactors conserved through all domains of life. Once assembled by dedicated ISC and/or SUF scaf- folds, Fe-S clusters are conveyed to their apo-targets via A-type carrier proteins (ATCs). ...
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<p>KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis</p>
... transcription factor 6 (ATF6), the foremost of which is the PERK-mediated PERK-eIF2 α -ATF4 ...important factor that switches the survival signal to a pro-death ...
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A role for type 111 interferons in the natural killer cell immune response to virus
... IFN stimulated gene IFN stimulated gene factor IFN stimulated response elements Immunoreceptor tyrosine-based inhibitory motif Janus kinase Killer immunoglobulin -like receptor Lymphokin[r] ...
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