IL-12p40
Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35
... of IL-12p35 was deleted were also studied, because a heterodimer of IL-12p40 and IL-12p35 polypeptides forms the active IL-12 ...containing IL-12p40 or IL- ...
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Local expression of immunoregulatory IL 12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice
... using IL-10–transduced islet-specific Th1 lymphocytes in NOD mice has been demonstrated recently to be useful ...the IL-12p40 gene, an an- tagonist of active IL-12, into islet grafts can be an ...
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The influence of JNK and P38 MAPK inhibition on IL-12P40 and IL-23 production depending on IL12B promoter polymorphism
... that IL-12p40 is a subunit of IL-23, we also determined the effect of IL12Bpro polymorphism on IL-23 ...low IL-23 production in stimulated PBMC ...the IL-23p19 gene contains an ...
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Toll like receptor dependent production of IL 12p40 causes chronic enterocolitis in myeloid cell specific Stat3 deficient mice
... TNF-α, IL-6, and iNOS in macrophages ...impaired IL-10–mediated suppression of the LPS-induced IL-12p40 expression in Stat3 mutant macrophages (Figure ...of IL-12p40 mRNA induced ...
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A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL 12p40 and IL 12p70 production
... of IL- 12p40 in patients with TAK, although Tripathy et ...that IL-12p40 mRNA was more highly expressed in patients with TAK than in HCs ...the IL-12p40 protein level in patients ...
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Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo
... particular IL- 12p70 acts upon T and NK cells to increases cytokine pro- duction, proliferation, and cytotoxicity, functions that become evident several hours after exposure to infections agents ...However, ...
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No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis
... alleles IL-12p40 pro1 and IL-12p40 pro2 has an influence on the expression of IL-12p40: The genotype IL-12p40 ...of IL-12p40 from PBMC in silicosis ...
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P2Y6 signaling in alveolar macrophages prevents leukotriene dependent type 2 allergic lung inflammation
... and IL-12p40 generation that counterbalances CysLT 1 R- induced T2I priming ...Df-induced IL-12p40 generation by BMMs (Figure ...reduced IL-12p40 generation in response to Df ...
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T-Cell mRNA Expression in Response to Mycobacterium bovis BCG Vaccination and Mycobacterium bovis Infection of White-Tailed Deer
... interleukin 12p40 (IL-12p40), IL-12p35, IL-23p19, FoxP3, IL-17, and GATA3 in PBL stimulated in vitro with purified protein derivative (PPD) of ...and IL-12p40 than ...
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Regulation of CD154 induced interleukin 12 production in synovial fluid macrophages
... that IL-12 plays an important role in synovial inflammation in ...synovial IL-12p70 production has not been ade- quately studied. Mainly IL-12p40 production has been addressed [26], and ...
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The crystal structure of titanium dioxide nanoparticles influences immune activity in vitro and in vivo
... Each NP was tested at least three times; in Additional file 1: Tables S1-S7 a representative result is shown. To establish the significance of the difference in induction of CD83, CD86, IL-12p40, TNF- α and ...
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Clinical Disease Caused by Klebsiella in 2 Unrelated Patients With Interleukin 12 Receptor β1 Deficiency
... played an absence of expression of IL12R  1. They presented with dissemi- nated BCG and salmonella disease (pa- tient 2) or with intraabdominal N nova infection (patient 2), and both later de- veloped Klebsiella sepsis. ...
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Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels
... ), IL-1  , IL-6, and ...only IL-12p40 and CXCL10, whereas astroglia produced these cytokines plus CCL2, CCL3, CCL5, CXCL1, G-CSF, IL-1  , IL-6, IL-12p70, and ...only ...
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Dreisbach, Julia (2005): Klonierung, Expression und funktionelle Analyse von Hühner-Interleukin-12. Dissertation, LMU München: Tierärztliche Fakultät
... reduzierende Wirkung hat und Disuldbrücken eventuell zestören kann. Für die Bestimmung des Molekulargewichts im Westernblot unter re- duzierenden und nichtreduzierenden Bedingungen konnte das ChIL-12p40 über sein ...
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R 848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes
... greater IL-12p40 production in monocytes of both HIV-infected (p < ...in IL-12p40 was observed in HIV- infected versus uninfected subjects (P = ...analyze IL-12p40 ...and ...
Correlation of Cytokine Gene Expression with Pathology in White-Tailed Deer (Odocoileus virginianus) Infected with Mycobacterium bovis
... Mycobacterium bovis-infected white-tailed deer (WTD) in northeast Michigan are a reservoir of mycobacteria that pose a threat to both domestic animals and humans. Relatively little work has been done to characterize the ...
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Immune response profile of caruncular and trophoblast cell lines infected by high (Nc Spain7) and low virulence (Nc Spain1H) isolates of Neospora caninum
... (IL‑4, IL‑10, IL‑8, IL‑6, IL‑12p40, IL‑17, IFN‑γ, TGF‑β1, TNF‑α), and endothelial adhesion molecules (ICAM‑1 and VCAM‑1) were investigated by RT‑qPCR, and protein ...
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Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-γ stimulated macrophages
... of IL-12p40 (AP-1: GAG ACT AGT CAG TTT, and ICSBP/NFAT: TCA GTT TCT ACT TTG GGT TTC CAT CAG ...Rockford, IL, USA) with biotin end-labeled DNA probes instead of radioactive ...
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Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype
... (G) IL-12p40 production by adhered and detached WT DCs in response to GM-CSF, and IL-10 production following LPS ...and IL-12p40 production (I) were then ...
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The effect of infliximab plus methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis: analyses from a randomized, placebo-controlled trial
... VEGF, IL-12p40, TNF-a, and CRP) that may be modulated by infliximab + MTX ...in IL-6, ICAM-1, MMP-3, and CRP levels were observed as early as week 2 and sustained through week 14 of treatment with ...
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