IL-2R: IL-2 receptor
Interleukin-2 Immunotherapy in Children
... JRA, juvenile rheumatoid arthritis; rIL-2, recombinant IL-2; NK, natural killer; IL-2R, IL-2 receptor.. In response to stimulation with antigens, acti-.[r] ...
9
Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours
... of IL-2 depending on the histological sub- type of lung ...of IL-2 was noted in tumour ...between IL-2 expression and the intensity of proliferative activity (expression of Ki-67 ...
8
Original Article The plasma level of soluble IL-2 receptor (sIL-2R) is elevated in children with acute Kawasaki disease
... that IL-2 sig- nals through a receptor complex consisting of three subunits, namely the IL-2Rα, IL-2Rβ and common ...γ-chain. IL-2 can bind IL-2R, ...
9
Development of a Macroarray To Specifically Analyze Immunological Gene Expression in Swine
... both IL-2 and the IL-2 receptor (IL-2R) in murine mixed leukocytes (20), human T cells (16), and porcine PBMCs (Table ...IFN-␥, IL-2, the ...
8
Association of Src-Related Kinase Lyn with the Interleukin-2 Receptor and Its Role in Maintaining Constitutive Phosphorylation of JAK/STAT in Human T-Cell Leukemia Virus Type 1-Transformed T Cells
... The IL-2-depen- dent, HTLV-1-immortalized T-cell lines MS9 and MS68 were estab- lished by infection of activated primary blood lymphocytes with the molecularly cloned provirus pHTLV-XIMT (39, ...human ...
5
Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors
... The IL-2 receptor (IL-2R) has been found to be express in a variety of epithelial cancer ...this receptor has been well characterized to activate lymphoid cells, its function on ...
9
Production of granulocyte/macrophage colony stimulating factor by human natural killer cells Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor
... the IL-2 receptor (IL-2R beta) and most NK cells express the CD2 (erythrocyte rosette) ...p55 IL-2R subunit, can be expressed after NK activation and may play a role in ...
10
Soluble IL 2R¿ (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice
... tolerance, IL-2 has also been somewhat paradoxically described play an important role in driving the proliferative response of activated T cells and as a critical factor in the generation of an appropriate ...
9
Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
... the IL-2 gene but not that of the IL-2R ...inhibit IL-2R mRNA levels by 50%, whereas lower doses (10(-6) M) inhibited by greater than 70% the accumulation of IL-2 ...
10
X-linked severe combined immunodeficiency disease and the gamma c receptor component: prospects for molecular diagnosis.
... for IL-2Rs includes the g chain as a component of both high- and intermediate-affinity receptor complexes (Table ...The IL-2R b chain is also a component of high-affinity receptors, while the ...
6
v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel.
... In this study, we demonstrated that three avian immunoregulatory receptors, major histocompatibility MHC antigens class I and class II as well as the interleukin-2 receptor IL-2R, were i[r] ...
12
Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross sectional study
... interleukin-2 receptor (sIL-2R) and interleukin (IL)-6, and an osteo-destruction marker, deoxypyridinoline, in synovial fluid (SF) samples obtained from 22 HTLV-I carriers and 58 control ...
8
Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preeclampsia
... and IL-6 levels are ...soluble IL-2 receptor (sIL-2R) of women with severe preeclampsia (sPE; A), superimposed preeclampsia (spPE; B), and chronic hypertension (CHTN; C) and controls ...
9
Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... Abbreviations: IL, interleukin; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; GHR, growth hormone receptor; IL-2R, interleukin 2 ...
11
Interleukin 2 and interleukin 2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
... of IL-2R mRNA and by immunofluorescence, IL-2R membrane ...of IL-2R with ACTH-positive cells and other cell types expressing the ...lymphocyte-produced IL-2, this ...
9
Suppression of cell mediated and humoral immune responses by an interleukin 2 immunoglobulin fusion protein in mice
... Since IL-2 displays high receptor affinity compared with blocking anti- CD25 antibodies, enormous amounts of antibodies would be required to inhibit IL-2–dependent cell proliferation in ...
8
CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility
... Characterization of SNPs rs809451, rs414171, and rs2239751 led to the assignment of three haplotypes (H1, H2, H3, Fig. 1b). The vast majority of T1D patients had the homozygous genotype H1/H1 (n = 199) whereas a lower ...
8
Novel interleukin 2 (IL 2) receptor appears to mediate IL 2 induced activation of natural killer cells
... recombinant IL-2 to the enriched NK cells promoted a rapid augmentation of cytolytic activity and a more delayed increase in cellular ...the IL-2-induced proliferative response in these cells, ...
7
Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.
... Representative sequences shown: v-Mpl 31, h-Mpl 34, human and murine IL-7R hIL-7R and mIL-7R 10, human and murine IL-2R ,B chain h-IL-2RP and mIL-2R,B 13, 21, human and murine erythropoi[r] ...
5
Signal transduction pathways activated by the IL 1 receptor family: ancient signaling machinery in mammals, insects, and plants
... (TNF), IL-1 is a determining cytokine in the pathogensis of inflammatory diseases such as rheumatoid arthritis ...by IL-1, cells display an inflamed phenotype in that a large number of genes become ...
8