IL-4 and IFN-Gamma
Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon gamma activation site like sequence upstream of the I epsilon exon in a human B cell line Evidence for the involvement of Janus kinase 3 and interleukin 4 Stat
... by IL-4 in the human B cell line, BL-2. Utilizing a IFN-gamma activation site-like DNA sequence element located upstream of the I epsilon exon, we demonstrated by gel mobility shift assays ...
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Cytokine Responses to Stimulation of Whole Blood from Patients with Buruli Ulcer Disease in Ghana
... or IL-10- induced downregulation of Th-1 responses plays a key role in the progression of early BUD and that healing is accompanied by an augmented Th-1 ...response. Gamma interferon (IFN- ␥ ), ...
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Temporal regulation of natural killer T cell interferon gamma responses by β-catenin-dependent and -independent Wnt signaling
... regulates IFN-γ responses; (ii) active suppression of hepatic Wnt/β-catenin signaling shortly after α-GalCer exposure biases cytokine responses toward IFN-γ production; (iii) β-catenin activity independent ...
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Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery
... cytokines IL-1β, TNF-α and IL-6, which are readily induced by the presence of lipopolysaccharides from Gram-negative bacteria [12] play an important role in the synthesis of acute phase proteins and often ...
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Original Article Role of dendritic cells in consistency between upper and lower airway inflammatory responses: animal experimental studies
... interferon gamma (IFN-γ) and interleukin 2 (IL-2), the increase of cyto- kines produced by Th2 such as IL-4 and IL-5, the penetration of specific IgE, and the activa- tion of ...
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Serological cytokine profiles of cardiac rejection and lung infection after heart transplantation in rats
... revealed 4 proteins (beta-Catenin, E-Selectin, IFN-gamma, and IL-13) in the serum of cardiac allograft rejection animals, and 11 pro- teins (CINC-3, CNTF R alpha, E-Selectin, FSL1, Hepas- ...
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Gamma Interferon (IFN-γ) and IFN-γ-Inducing Cytokines Interleukin-12 (IL-12) and IL-18 Do Not Augment Infection-Stimulated Bone Resorption In Vivo
... effects, IL-12, IL-18, and IFN-␥ also suppress the receptor-activator of NF-B ligand (RANKL)-induced osteoclast differentiation and mature osteoclast function in ...of IFN-␥ is exerted at ...
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Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?
... as IL-4, IL-5 and IL-13, the immunological and cellular profiles of non-atopic asthma are not well ...of IFN-γ but not IL-4 by bronchoalveolar lavage cells [4]; b) ...
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Increased Levels of Alternatively Spliced Interleukin 4 (IL-4δ2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis
... interleukin 4 (IL-4) induces and gamma interferon (IFN- ␥ ) inhibits collagen ...investigated IL-4 and IFN- ␥ transcripts in peripheral blood mononuclear cells and ...
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Cytokine Response in Multiple Lymphoid Tissues during the Primary Phase of Feline Immunodeficiency Virus Infection
... (first 4 months) of feline immunodeficiency virus (FIV) infection in lab- oratory ...and gamma interferon (IFN- g ...for IFN- g , IL-12p40, IL-4, and IL-10, while ...
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IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13
... the IL- 13Rα1 and IL-4Rα ...of IL-13Rα2, as evidenced by both the relative receptor density and the fraction of cells bearing ...of IL-13Rα2 in human [42] and murine ASM cells upon ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... In CP gram-negative anaerobic bacteria induce the at- tachment loss of tooth from its supporting tissues. This mechanism has been mediated by some regulatory and inflammatory cytokines. In other words, cytokines con- ...
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<p>Eosinophilic gastroenteritis: diagnosis and clinical perspectives</p>
... regulate eosinophilic homing into the lamina propria of the stomach and small intestine. The importance of eotaxin in EGE was shown by Hogan et al 34 in an animal model of food allergen – induced EGE, in which they ...
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Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
... These classes of inflammatory cells produce an assortment of cytokines, such as tumor necrosis factor alpha TNF-a, alpha interferon IFN-ot, gamma interferon IFN-y, interleukin-1 alpha IL[r] ...
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Original Article Docosahexaenoic acid suppresses pro-inflammatory macrophages and promotes anti-inflammatory/ regulatory macrophage polarization through regulation of cytokines
... and IL-6) and increased expression of anti-inflammatory cytokines (IL-4 and ...secrete IL-12 to affect Th-1 cells, while M2 macrophages secrete IL-4 to affect Th-2 and Mreg ...
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Cytokine production in the immune response to murine gammaherpesvirus 68.
... for IL-2 and 72 h for all other ...for IL-10 and below 1 U/ml for the other ...for IL-2, IL-6, and IFN-g and as nanograms per milliliter for ...No IL-4 or IL-5 was ...
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Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation
... Cells were collected from the above experiments and washed twice with PBS. Total Protein Extraction Kit (Bestbio Inc. Shanghai, China) with protease inhibitor and phosphatase inhibitor was used to lyse target cells for ...
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Cytokine patterns in nasal secretion of non-atopic patients distinguish between chronic rhinosinusitis with or without nasal polys
... CRSsNP. IL-5, IL-10, IL-12, IL-17, and IFN-γ represent a disequilibrium of T cells in NP, and ECP, tryptase, G-CSF, MCP-1, MIP-1α, and MIP-1β depict the activation of various ...
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Deficiency of Vitamin D in HIV Infected Patients and Its Effect on Some of the Immunological Parameters
... creased levels of IL-6, decreased levels of IL-10, IFN-γ and TNF-α. There’s active immune inflam- mation when there are reduced 25(OH)D serum levels and it leads to stimulated secretion of the ...
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Immunological profiles in HIV positive patients with or without opportunistic infections and the influence of highly active antiretroviral therapy: a systematic review and update
... this, IL-10 a Th-2 expressed cytokine is significantly elevated during chronic HIV disease, which is correlated with HIV viral load ...instance, IL-10 suppresses replication of HIV within macrophages [79], ...
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