immediate-early gene expression of
Monitoring immediate-early gene expression through firefly luciferase imaging of HRS/J hairless mice
... ferase expression in the tail, paws, ears, and nose, suggest- ing similar control of the two immediate-early gene upstream sequences used in creating these mouse ...additional ...
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Interaction between the Human Cytomegalovirus UL82 Gene Product (pp71) and hDaxx Regulates Immediate-Early Gene Expression and Viral Replication
... and immediate-early gene expression when cells are infected at a low ...induce immediate-early gene expression and are severely attenuated for viral ...UL82 ...
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The Human Cytomegalovirus Major Immediate-Early Distal Enhancer Region Is Required for Efficient Viral Replication and Immediate-Early Gene Expression
... this region do not share appreciable structural homology to other herpesvirus ORFs and are of unknown significance. Mu- rine cytomegalovirus has putative ORFs (m124, m124.1, and m125) in its enhancer, but they do not ...
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Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression.
... of expression of the essential immediate-early (IE) gene of pseudorabies virus influences virus replication and virulence, we replaced the IE promoter with the tissue-specific promoters of the ...
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Inhibition of Human Cytomegalovirus Immediate-Early Gene Expression by Cyclin A2-Dependent Kinase Activity
... IE gene expression as the critical first step of the HCMV lytic cycle is under the control of cell type-, cell differen- tiation-, and cell cycle-dependent mechanisms that are poorly un- derstood at the ...
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Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... viral immediate-early (IE) ...IE gene expression during lytic infection had not been fully ...IE gene promoters in a manner dependent mostly on the presence of the activation domain of ...
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Human Cytomegalovirus UL47 Tegument Protein Functions after Entry and before Immediate-Early Gene Expression
... very early in the replication cycle was ...viral immediate-early 1 gene was delayed by 8 to 10 ...major immediate-early ...
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Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression
... reporter gene without known protective elements was active in cultured rat sensory ...the expression of multi- ple genes from separate promoters in fully IE gene-disabled HSV vectors, providing an ...
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The 19S Proteasome Activator Promotes Human Cytomegalovirus Immediate Early Gene Expression through Proteolytic and Nonproteolytic Mechanisms
... IMPORTANCE Proteasome inhibitors decrease or eliminate 20S CP activity and are garnering increasing interest as chemotherapeutics. How- ever, an increasing body of evidence implicates 19S RP subunits in important ...
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Roles of Polypyrimidine Tract Binding Proteins in Major Immediate-Early Gene Expression and Viral Replication of Human Cytomegalovirus
... U2AF65 gene expression was under the control of the CMV ...PTB1 expression plasmid that could produce PTB in HEP-2– kdPTB cells, we mutated the nucleotide corresponding to the shRNA (sequence, 5⬘-CCG ...
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Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression.
... Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICPO exhibit impaired growth in cell culture. GAL4-VP16 is an unusually potent transcription[r] ...
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Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... long-term expression, achieved by use of the IRES–-geo in- sertion in the LAT locus, can be harnessed in a multiple mu- tant in which cytotoxicity and other adverse effects of IE pro- teins are largely ...
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Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis.
... rates of transcription and accumulation of functional ICPO mRNA, while 0.5 h of infected cell protein synthesis prior to addition of the drug was required for maximal expression of ICP22[r] ...
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Cellular SNF2H Chromatin Remodeling Factor Promotes Herpes Simplex Virus 1 Immediate Early Gene Expression and Replication
... encode gene products that function to counteract this in- hibitory cellular response by coordinating the modification of these histones and/or by remodeling the viral chromatin state through the redirection of ...
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Inhibition of human cytomegalovirus immediate early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro
... Since AP1, a downstream transcription factor of the JNK pathway, is required for HCMV MIE enhancer/pro- moter activation, and the JNK inhibitor abolishes HCMV replication [24, 25], the EtOAc fraction of ESE may in- hibit ...
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Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression
... PENK expression in striatal ...in immediate early gene expression almost exclusively within enkephalin-contain- ing projection neurons and non-projection interneurons of the striatum ...
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Structure and expression of murine cytomegalovirus immediate-early gene 2.
... Transac- tivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IEl: mutational analysis of the viral proteins. Inserti[r] ...
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Repression of adenovirus early gene expression by coinfection with a temperature-sensitive mutant in the immediate-early gene of pseudorabies virus.
... Our ap- proach was to coinfect cells at the nonpermissive tempera- ture with wild-type adenovirus and a temperature-sensitive mutant in the immediate-early gene of either pseudorabies vi[r] ...
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Adenovirus homologous recombination does not require expression of the immediate-early E1a gene.
... To investigate whether early genes other than those involved directly in DNA replication are required for efficient adenovirus recombination, pairs of viruses with deletions in Ela, Elb [r] ...
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trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus.
... (a) Response of the HSV IE175-CAT and 38K-CAT hybrid genes (1.0 Fg of input target plasmid DNA) to cotransfection with 0.5 ,ug of effector plasmid DNA containing either the HCMV (Towne) [r] ...
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