Immune checkpoints
Immune checkpoints in chronic obstructive pulmonary disease
... Cell-mediated immune responses are vital to the body ’ s defence against infection and play a key role in tumour ...of immune-regulatory receptor–ligand interactions or immune ...limit immune- ...
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Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
... other immune checkpoints or coinhibitory receptors besides PD-1 and ...emerging immune checkpoints under preclinical and clin- ical development for cancer ...
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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
... evaluated immune profiles. We identified that upregulation of other immune checkpoints, most notably TIM-3, on therapeutic antibody-bound T cells as a marker of treatment ...alternate immune ...
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Orchestration of immune checkpoints in tumor immune contexture and their prognostic significance in esophageal squamous cell carcinoma
... of immune checkpoints such as PD-1, TIGIT, PD-L1, and ...of immune checkpoint factors influencing prog- nosis are important for improving patient management of ...
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Soluble immune checkpoints in cancer: production, function and biological significance
... PD-1 and CTLA-4 are excellent examples of immune checkpoints. Unlike other members of the CD28 family, PD-1 can only transduce signals when crosslinked with BCR or TCR. Various studies have confirmed that ...
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Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function
... We enrolled 103 patients: 72 were stage IV cancer pa- tients with ME, and 31 were patients with operable dis- ease (not stage IV) who underwent surgical resection. Detailed information of the patients from which PB, ME, ...
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<p>OX40 (CD134) and OX40 ligand, important immune checkpoints in cancer</p>
... new immune therapies are ...the immune response to the speci fi c ...other immune checkpoints to add more ideas to tumor feasible ...cancer, immune checkpoints, OX40/OX40L, ...
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Expression of immune checkpoints in T cells of esophageal cancer patients
... overcome immune resistance, and induce clinical responses in patients with melanoma, renal cell carcinoma and non- small cell lung cancer ...Therefore, immune checkpoints are promising ...
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Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
... inhibitory immune checkpoints (VISTA, TIGIT, PD-1, IDO1, CTLA-4, and PD-L1, among ...Many immune checkpoint molecules (IDO1, LAG3, TIGIT, VISTA, PD- 1, PD-L1 and CTLA-4) expressed significantly ...
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The Complex Interaction between the Tumor Micro-Environment and Immune Checkpoints in Breast Cancer
... 2. Immune checkpoints of immunosuppressive actions associated with breast ...cancer. Immune checkpoints of inhibitory pathways are fundamental in the immune system to maintain ...
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Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix
... the immune checkpoints CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and CD274 (Programmed death-ligand 1, PD-L1 or B7H1) have been approved for the treatment of several cancer types, further ...
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Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases
... anti-tumoral immune responses in primary tumors are also relevant for brain ...of immune checkpoints may not only increase immune responses in the periphery, but also prevent macrometastasis ...
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Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
... Heterogeneity of tumor cells and their microenvironment can affect outcome in cancer. Blockade of immune checkpoints (ICPs) expressed only on a subset of immune cells leads to durable responses in ...
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Targeting immune checkpoints in breast cancer: an update of early results
... (table 2). Although no ORs were achieved, SD lasting for more than 12 weeks was observed in 42% of the patients. The combined treatment reduced the presence of circu- lating Tregs and increased the number of circulating ...
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Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
... Macrophages can be classified as pro-inflammatory and anti-inflammatory, also known as classic (M1) and alternative (M2). TAMs are another subset of cells that seem to affect responses to immunotherapy and are key ...
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A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy
... other immune checkpoints such as Tim-3, LAG-3, OX-40, ICOS has also been explored [22–24] and some inhibitors have been investigated in clinical ...these immune checkpoints in ESCC remains ...
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Potential role of immunological factors in early diagnosis of cancer cachexia in C26 tumor-bearing mice
... when immune cells are reduced and/or affected by inhibitory signals such as immune checkpoints molecules including T-lymphocyte-associated antigen 4 (CTLA- 4) and programmed cell death protein 1 ...
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DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer
... develop immune resistance mechanisms, which involves multiple immune inhibitory pathways ...multiple immune checkpoints/ligands, including PD-1, CTLA-4, and PD-L1 to support immune ...
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<p>Siglecs, Novel Immunotherapy Targets, Potentially Enhance The Effectiveness of Existing Immune Checkpoint Inhibitors in Glioma Immunotherapy</p>
... negative immune regulation can be used to treat ...of immune checkpoints have been investigated in research and clinical trials, demon- strating remarkable ...of immune checkpoint inhibitors ...
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Development and validation of an immune checkpoint-based signature to predict prognosis in nasopharyngeal carcinoma using computational pathology analysis
... 9 immune checkpoints consistent with 13 features tested are shown in Additional file 1: Figure ...the immune checkpoints was digitally measured and quantified as the positive expression ...
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