in-vitro protoporphyrin-ix
In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue
... The detection of premalignant and early-malignant endo- bronchial alterations is growing increasingly important in the diagnosis of lung cancer, since an acceptable progno- sis is strictly confined to the early stage of ...
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In Vitro Culture of Shell Gland Epithelial Cells in Japanese Quail (Coturnix coturnix japonica)
... in vitro properly at least 4 hours. Moreover, released protoporphyrin IX from the cells were measured using a spectrofluo- rometer equipped a filter pair; 400 nm/30 nm bandwidth excitation filter and ...
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Carbon dot-protoporphyrin IX conjugates for improved drug delivery and bioimaging
... Fowley et al. (2013) first reported the formation of a PpIX and CD conjugate with a Fo¨rster resonance energy transfer (FRET) mechanism for enhanced PDT. In this study,the decreased dark toxicity based on the increase of ...
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Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
... oncogenic transformation increases 5-ALA-induced PpIX accumulation [23–25], we originally speculated that oncogenic Ras activation stimulates the heme biosynthesis pathway, resulting in increased PpIX accumulation in ...
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Zinc Protoporphyrin IX Binds Heme Crystals to Inhibit the Process of Crystallization in Plasmodium falciparum
... iron protoporphyrin IX (FePPIX), a byproduct of this proteolysis, is not catabolized by heme oxygenase as it is in mammalian cells, but instead is converted into a unique FePPIX crystal called hemozoin ...
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Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA PDT in vitro
... induced Protoporphyrin IX photobleaching exhi- bited a complex series of photophysical and photoche- mical reactions and the bleaching kinetics are much more complicated ...the Protoporphyrin ...
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Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions
... In vitro diffusion experiments using Franz-type cells and porcine skin were ...from protoporphyrin IX was documented by confocal laser scanning microscopy ...
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Synthetic Porphyrinic Macrocycles for Photodynamic Therapy and Other Biological Applications
... Protoporphyrin IX and its metal derivatives have been used as photosensitizers in photodynamic therapy (PDT) for the treatment of ...In vitro and in vivo studies show that protoporphyrins accumulate ...
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Inhibition of Hepadnavirus Reverse Transcriptase-ε RNA Interaction by Porphyrin Compounds
... in vitro RNA binding assay, we found that hemin, protopor- phyrin IX, protoporphyrin IX disodium, and biliverdin could all inhibit MiniRT2- ε RNA interaction in a dose-dependent fashion ...
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Klein, Susanne (2005): Einfluss verschiedener Faktoren auf die durch 5-Aminolävulinsäure und ihre Ester induzierte Protoporphyrin IX - Fluoreszenz in Zervixkarzinomzelllinien. Dissertation, LMU München: Medizinische Fakultät
... Zellen sensitiver für die PDT. Der PpIX-Anstieg resultiert aber nicht nur daraus, dass PpIX nicht weiter zu Häm umgewandelt wird, sondern auch daraus, dass die negative Rückkopplung der nun in geringerer Menge gebildeten ...
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Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver
... Administration of a heme oxygenase inhibitor zinc protoporphyrin IX 1 ,uM eliminated the baseline CO generation, and the vascular resistance exhibited a 30% elevation concurrent with dis[r] ...
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Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells
... Results: By employing a drug repurposing approach, we found that protoporphyrin IX (PpIX), a metabolite of ami‑ nolevulinic acid applied in photodynamic therapy of cancer, stabilizes T[r] ...
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1201.pdf
... The active site of cytochrome P-450 contains a single iron protoporphyrin IX prosthetic group, and it is here that dioxygen is bound, reduced and activated. An overview of its catalytic cycle is shown in ...
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Stem Cell Transplantation Increases Antioxidant Effects in Diabetic Mice
... cobalt-protoporphyrin IX in recipient mice before conditioning and bone marrow transplantation (BMT) results in a reduction of GVHD and improved sur- vival ...
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A quantitative study of in vivo protoporphyrin IX fluorescence build up during occlusive treatment phases
... Background: Topical photodynamic therapy (PDT) is a non-invasive light based ther- apy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX ...
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Porphyrin magnetite nanoconjugates for biological imaging
... In summary, we have successfully synthesised a new two-in-one magnetic-fluorescent nanocomposite. Initial co-incubation experiments performed with THP-1 macrophage cells in the presence of the PMNC showed a distinct ...
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Intermolecular Bonding of Hemin in Solution and in Solid State Probed by N K-edge X-ray Spectroscopies
... iron protoporphyrin IX chloride (FePPIX-Cl, or hemin, Figure 1a) forms monomer species when dissolved in dimethyl sulfoxide (DMSO), while dimer structures are present in aqueous ...
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Light harvesting in silicon(111) surfaces using covalently attached protoporphyrin IX dyes
... X-ray Photoelectron Spectroscopy: XPS measurements on the samples were performed on a Thermo Fisher ME17 Thetraprobe system with a monochromatic Al X-ray source, set to a 400 µm spot size. The scan count was set to 500 ...
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Light harvesting in silicon(111) surfaces using covalently attached protoporphyrin IX dyes
... We report the photosensitization of crystalline silicon via energy transfer using covalently attached protoporphyrin IX (PpIX) derivative molecules at different distances via changing the diol linker to the ...
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Analysing avian eggshell pigments with Raman spectroscopy
... Raman spectroscopy is a vibrational spectroscopic method that is widely used for characterising molecules (Lewis and Edwards, 2001). In addition to being non-destructive, Raman spectroscopy requires no specialised sample ...
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