Insulin deficiency
Effect of glucagon on glucose production during insulin deficiency in the dog
... of insulin deficiency in the absence of basal glucagon resulted in an initial (30%) drop in GP followed by a restoration of normal GP after 2--3 h and moderately enhanced glucose formation from alanine and ...
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Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans
... Insulin deficiency decreases tissue protein synthesis, albumin mRNA concentration, and albumin synthesis in ...contrast, insulin deficiency does not change, or, paradoxically, increases ...
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The effect of experimental insulin deficiency on glucagon secretion
... metabolites within the alpha cell might be essential for suppression of glucagon secretion, and that in diabetes an intracellular deficiency of glucose secondary to insulin lack might be responsible for the ...
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CHARACTERIZATION OF A RAT MODEL OF INSULIN DEFICIENCY INDUCED VASCULAR COMPLICATION
... glucose, insulin, tumour necrosis factor α (TNFα), cholesterol, low density lipoprotein cholesterol (LDL-C), advanced glycation end products (AGEs) and arginase ...
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Sitagliptin is effective and safe as add on to insulin in patients with absolute insulin deficiency: a case series
... with insulin has recently been approved in the USA based on the large amount of clinical data ...endogenous insulin secretion (that is, no residual b -cell functions; for example, advanced type 2 diabetes ...
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Atypical Feature of Diabetic Ketoacidosis with Low or Normal Plasma Glucose: a Narrative Review
... of insulin drip together with a dextrose-containing fluid until the normalization of anion gap and bicarbonate ...of insulin are required to reverse the severe acidosis in EuDKA patients, higher ...
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Abnormal GTT (Glucose Tolerance Test) in Multitransfused β Thalassemia Major Patients –In Vivo Biochemical Reactionary Effect
... to insulin deficiency resulting from toxic effect of iron deposited in pancreas and from insulin ...The insulin resistance may come from iron deposition in ...with insulin resistance ...
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Incidence of Diabetes Mellitus in Patients with Hepatitis B and C virus Infection
... Insulin deficiency is defined as a pathological condition in which there is an in appropriate decrease in the rate at which the β-cell secretes ...of insulin in plasma are defined as a function of ...
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Simulation and qualitative analysis of glucose variability, mean glucose, and hypoglycemia after subcutaneous insulin therapy for stress hyperglycemia
... subcutaneous insulin therapy that should be used in this clinical scenario, however, is ...of insulin resistance and insulin deficiency that defined their unique stress hyperglycemia state; ...
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Characteristics of Membrane Bound and Free Hepatic Ribosomes from Insulin Deficient Rats I ACUTE EXPERIMENTAL DIABETES MELLITUS
... Membrane-bound and free ribosomes were prepared by discontinuous density gradient centrifugation from livers of rats 2-3 days after receiving alloxan (75 mg/kg) or streptozotocin (100 mg/kg). Hepatocytes from these ...
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Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression
... to insulin deficiency (Table ...Serum insulin was reduced to the same extent in Sham-STZ, ADX-STZ, and in ADX-STZ-Fast groups, compared to control mice, as would be expected with streptozotocin ...
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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
... than insulin deficiency, is the sine qua non of ...in insulin deficiency; (b) hyperglucagonemia is present in every form of poorly controlled diabetes; (c) the glucagon suppressors leptin and ...
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Review on Diabetes Mellitus
... Insulin deficiency depresses glucose transport into the cell and glycogen synthesis in the ...breakdown. Insulin lack leads not only to underutilization of glucose at the cellular level but also ...
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The Effect of Lowering the Threshold for Diagnosis of Impaired Fasting Glucose
... criteria. In reality, optimization requires conside- ration of the costs of predicting or not predicting a diagnosis of diabetes when diabetes does or does not ultimately develop. There also may be an ethnic difference ...
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Tuberculosis and diabetes: the deadly duo
... malnutrition stimulate the stress hormones epinephrine, glucagon, cortisol and growth hormone, which acting synergistically raise the blood sugar levels. Plasma levels of IL-1 and TNF alpha are also raised in severe ...
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Regulation of glucose turnover during exercise in pancreatectomized, totally insulin deficient dogs Effects of beta adrenergic blockade
... Present and previous data in normal and alloxandiabetic dogs, suggest that a in total insulin deficiency, control of hepatic glucose production during exercise is shifted from glucagon t[r] ...
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Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver
... to insulin, controlling the metabolism of both glucose and lipids [27, ...and insulin resistance [7, 25, ...hepatic insulin re- sistance [7, 30]. Our study has revealed impaired ...
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Critical role of stearoyl CoA desaturase–1 (SCD1) in the onset of diet induced hepatic insulin resistance
... and insulin levels, induce fatty liver, and suppress the expression of Glc-6-Pase and PEPCK within just 4 days ...SCD1 deficiency on hepatic glucose fluxes, on Glc-6-Pase and PEPCK expression, and on liver ...
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Manifestation of renal disease in obesity: pathophysiology of obesity-related dysfunction of the kidney
... mechanism. Insulin resistance from excess fatty acids is exacerbated by decreased secretion of high molecular weight adiponectin from adipose cells in the obese ...potentiates insulin in its post-receptor ...
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PPARα deficiency reduces insulin resistance and atherosclerosis in apoE null mice
... Vascular disease is the most common cause of death in people with type 2 diabetes, which is characterized by obesity, hyperglycemia, hyperinsulinemia, hyperten- sion, and dyslipidemia. Insulin resistance is ...
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