insulin-like growth factor axis
Targeting insulin-like growth factor axis in hepatocellular carcinoma
... of growth hormone could also contribute to the disappointing activity of this class of ...to insulin resistance secondary to high levels of growth hormone, a compensatory reaction to IGF-1R ...
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<p>Biomarkers of Insulin and the Insulin-Like Growth Factor Axis in Relation to Breast Cancer Risk in Chinese Women</p>
... of insulin and IGF factors with breast cancer persisted after adjustment for age, BMI, age at menarche, and menopausal status, and these associations did not differ markedly across strati fi ca- tions of these ...
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Insulin-Like Growth Factor Axis Expression in Dental Pulp Cells Derived From Carious Teeth
... In this study, IGFBP-3 was consistently downregulated in cDPCs under mineralizing conditions again confirming previ- ous data in hDPCs. Early studies suggested that the expression of IGFBP-3 can be regulated by ...
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Effects of Exogenous Growth Hormone on Growth Hormone Insulin Like Growth Factor Axis of Human Gastric Cancer Cell
... human growth hormone had increased not only the blood level of IGF-I and IGFBP-3 but also the mRNA expression of IGFBP-3 gene in tumor tissue, but had decreased the rate of IGF-I/IGFBP-3 in the mean ...
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Insulin like growth factor axis in pregnancies affected by fetal growth disorders
... and IGF2 expression in growth-restricted fetuses are in- consistent [9–16]. The bioavailability of IGFs is modulated by their seven binding proteins (IGFBP) [17]. The affinity of IGFBP3 for IGFs is higher than ...
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Liver spleen axis, insulin like growth factor (IGF) I axis and fat mass in overweight/obese females
... and insulin, homeostasis model assessment of insulin resistance (HOMA), cholesterol and triglycerides, HDL-cholesterol, transaminases, high-sensitive CRP, uric acid, IGF-I, IGF binding protein (BP)-1, ...
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A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action
... IGFBP-4 proteolysis is dependent on the presence of IGF [42] and IGF1 was included in these assays (Methods section and see below). Fig. 2a shows that intact 28 kDa IGFBP-4 was proteolysed following incubation with ...
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Combined sprint and resistance training abrogates age differences in somatotropic hormones
... serum growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in re- sponse to a combined sprint ...
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Ovine placental lactogen and insulin like growth factor I : a study of their biological actions and potential to enhance animal production : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand
... alter growth rate. Although newborn lambs are reported to exhibit adult-like binding of GH to hepatic receptors (Gluckman et ...GH-IGF-I axis is not fully developed in young lambs compared with the ...
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Insulin like growth factors and insulin like growth factor binding proteins in mammary gland function
... Although there are conflicting data from clinical and epi- demiological studies concerning cancer risk and progno- sis, the proven role of IGFs and the IGF-IR in promoting proliferation and survival strongly implicates a ...
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The Role of Insulin like Growth Factor-1 (IGF-1) in the Diagnosis of Colorectal Carcinoma. A Case Control Study
... circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer ...(IGF) axis may be important in the development of colorectal ...between insulin like ...
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Insulin like factor 3 and the HPG axis in the male
... Insulin-like factor 3 has been described as a “neohormone” (45, 46), ...bone growth in the male (38) is closely linked to male reproductive behavior, another typical neohormone para- meter ...
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Adaptation of the growth hormone and insulin like growth factor I axis to chronic and severe calorie or protein malnutrition
... The hierarchy of diet components (e.g., protein, carbohydrate, vitamins, and minerals) influencing growth hormone (GH), insulin-like growth factor-I (IGF-I), and their binding proteins ...
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Bioactive Compounds for the Treatment of Renal Disease
... Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however ...
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THE INSULIN-LIKE GROWTH FACTORS.pdf
... one insulin receptor alpha and beta subunit and one IGF-I receptor alpha and beta ...the insulin receptor immunoprecipitated IGF-I binding activity ...human insulin receptor immunopreciptiated IGF-I ...
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Changes in pain and insulin like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides
... from growth hormone (GH) deficiency, with impaired growth hormone responses leading to reduced insulin-like growth factor 1 (IGF-1), a critical mediator of growth hormone ...
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Children With Idiopathic Short Stature Are Poor Eaters and Have Decreased Body Mass Index
... delayed growth and pubertal development; how- ever, in a strict sense, the diagnosis cannot be made before the time of puberty, when a delay in sexual maturation becomes ...
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Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study
... The CKDu group however showed lower standard er- rors and had fold changes of significant difference to the Kandy healthy group for some of the genes. Significant difference was observed between the KH group and early ...
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<p>Downregulated level of insulin in COPD patients during AE; role beyond glucose control?</p>
... eases like coronary heart disease and type 2 diabetes, 7 we detected hyperinsulinemia and hypolipidemia in COPD patients, indicating the different pathological state of the dis- ...ease. Insulin regulates ...
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Mechanisms regulating bone resorption in vitro
... Ep475, like CA074, is a negatively charged compound with limited membrane permeability. Unlike CA074, however, it proved to be an efficient inhibitor of bone resorption. Ep475 is a rapid inactivator of cathepsins ...
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