insulin-producing cells
LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells
... A great deal of effort has been made to optimize the timing of the activation or inhibition of key signaling pathways to obtain higher differentiation efficiency and better maturation of IPCs derived from stem ...
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GTK Tyrosine Kinase-induced Alteration of IRS-protein Signalling in Insulin Producing Cells
... rat insulin 1 promoter exhibit an increased  -cell mass as a consequence of a larger pancreas and an increased relative  -cell area ...the insulin promoter, show similar fea- tures as the GTK-transgenic ...
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Differentiation Potential of Nestin (+) and Nestin (-) Cells Derived from Human Bone Marrow Mesenchymal Stem Cells into Functional Insulin Producing Cells
... stem cells (MSCs) from human patients provides hope for curing numerous diseases and ...(+) cells from human bone marrow MSCs, and differentiate these cells into functional insulin ...
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Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells
... into insulin-producing cells and their use in ameliorating diabetes in streptozotocin-induced diabetes in rats or mice [19, 40, ...ated cells, whether they would further multiply or die after ...
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Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin producing cells
... stem cells de- rived from Balb/c mice could be trans-differentiated into insulin-producing cells (IPCs), but this process requires more than 2 months to generate the ...
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BM MSCs Differentiated Insulin Producing Cells Produce More Insulin in Presence of EGF than of FGF
... stem cells were cultured in glucose rich ...increases insulin content in cells derived from adult stem cells at a 5 mol/l mconcentration ...beta cells, either from ducts or from islets, ...
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Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
... stem cells (ESCs), newly developed induced pluripotent stem cells (iPSCs) can be prolifer- ated and differentiated to specific cell types [1, 2], indi- cating a promising approach to generating ...
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The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells
... glucose-regulated insulin-producing cells ...liver cells into IPCs, both in vivo in mice and in vitro in human tissue [3 – ...of cells in which the capacity for insulin produc- ...
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Regulation of insulin producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR
... The insulin signaling pathway plays a prominent role in the regulation of metabolism, growth, stress resistance and lifespan both in mammals and in Drosophila (Baker and Thummel, 2007; Birse et ...Drosophila ...
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Original Article Partially repair damaged Islets of diabetic rat model via insulin-producing cells differentiated from human umbilical cord mesenchymal stem cells infusion
... stem cells in the Wharton’s jelly of human umbilical cords are accepted as a promising alternative transplant ...stem cells (HUMSCs) were induced to differentiate into insulin-producing ...
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Pdx1 transfected adipose tissue derived stem cells differentiate into insulin producing cells in vivo and reduce hyperglycemia in diabetic mice
... ABSTRACT Insulin-dependent diabetes mellitus (IDDM) is characterized by the rapid develop- ment of potentially severe metabolic abnormalities resulting from insulin ...of insulin-producing ...
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Production of insulin producing cells from cord blood mesenchymal stem cells and their potential in cell therapy
... Four Albino Wistar rats, aged (6 to 15 weeks) old, weighed (165-205g) were obtained from the Experimental Animals Center, Faculty of Veterinary Medicine, University of Khartoum, Sudan. To induce type 1 DM, 30mg/kg of ...
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Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells
... T cells and/or exposure to soluble products of these cells, such as cytokines and free ...in insulin-dependent diabetes mellitus ...in insulin producing β-cells [2], but also ...
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Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila
... ABSTRACT Insulin-producing cells (IPCs) in the Drosophila brain produce and release insulin-like peptides (ILPs) to the ...mammalian insulin and insulin-like growth factors ...in ...
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Detection of amplifiable mRNA extracellular to insulin producing cells: potential for predicting beta cell mass and function
... proliferating insulin-producing cell lines in culture appar- ently pass many gene transcripts into the extracellular environment and that these transcripts can be reproduc- ibly ...of ...
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Insulin producing cells could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells
... with insulin prolongs survival and improves glycemic control, and current standard diabetes treat- ment regimens with insulin replacement remain away from ...for insulin replacement [1] but is often ...
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Embryonic stem cells differentiate into insulin producing cells without selection of nestin expressing cells
... low insulin levels, demonstrate that the cells are comparable to embryonic beta cells and do not represent definitive islet ...hepatocyte-like cells that corresponded to a fetal developmental ...
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Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats
... the insulin- producing cells derived from MSCs of Wharton’s jelly with modified three stages β cell differentiation method ...differentiated insulin-producing cells into their ...
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Rapid and reversible secretion changes during uncoupling of rat insulin producing cells
... of insulin-producing cells by a mechanism which is dependent on cell contact and is not associated with detectable pleiotropic perturbations of the cell secretory ...
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Exendin-4 enhances the differentiation of Wharton’s jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers
... Interestingly, our results demonstrated that MafA transcript levels could be induced by exendin-4. MafA controls and activates the expression and secretion of in- sulin [45]. It is noteworthy here that exendin-4 at the ...
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