insulin receptor substrate-1
Insulin receptor phosphorylation, insulin receptor substrate 1 phosphorylation, and phosphatidylinositol 3 kinase activity are decreased in intact skeletal muscle strips from obese subjects
... 0.9). Insulin- stimulated 2-deoxyglucose uptake was 53% lower in muscle strips from obese ...M insulin for 2, 15, or 30 ...the insulin receptor and insulin receptor ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth factor in ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative ...Pim substrate(s) that could help define the pathway regulated by ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI ...
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The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects
... identify insulin receptor substrate 1 (IRS-1) gene polymorphism Gly972Arg as the risk factor for ischemic stroke among Indonesian ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... Genomic DNA samples were extracted from peripheral blood lymphocytes of patients using TIANamp Blood DNA kits (Tiangen Biotech CO., LTD. Beijing, China). DNA concentration and quality were assessed using absorbance ...
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Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin binding and a parallel increase in insulin-stimulated receptor phosphorylation in muscle of fasting and streptozotocin-induced (STZ) diabetic ...overall receptor phosphorylation in ...
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L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... of insulin to insulin receptors leads to the phosphorylation of tyrosine in IRS, which activates PI3K and subsequently phosphorylates Akt ...in insulin signaling and the control of glucose ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... of insulin on bone formation may be related to its abil- ity to stimulate cell proliferation (1, ...pancreatic insulin production lose bone rapidly, and this loss is off- set by insulin ...
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... b 1 signalling by IGF-IR inhibition is likely a consequence of two ...b 1-primed Akt phosphorylation but also prevented the ABDP-induced sensitisation of the cells to this ligand, greatly reducing ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... clear insulin-resist- ance phenotype after PMA treatment, at the level of glucose ...onstrates insulin-stimulated glucose uptake ...inhibited insulin-stimulated glucose transport (Kaiser and James, ...
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A common amino acid polymorphism in insulin receptor substrate 1 causes impaired insulin signaling Evidence from transfection studies
... vivo insulin signaling has been most directly demonstrated in mice made deficient in IRS-1 using targeted gene knockout by homolo- gous recombination (31, ...in insulin and IGF-1–stimulated ...
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... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and ...
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MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
... the insulin receptor substrate 1 (IRS1) was a direct functional target of miR-1225-5p in glioblastoma, and the mRNA and protein levels of IRS1 in six human glioblastoma cell lines (A172, ...
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Understanding the mechanisms of aromatase inhibitor resistance
... (insulin receptor substrate 1), SERPINA3, TFF1 and TFF3 (trefoil factors 1 and 3) and proliferation markers (CDC2, Cyclin B1, CKS2, thymidylate synthase (TYMS), proliferating cell ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... with insulin resistance, salt sensitivity and non-dipper hypertension ...were 1) to investigate the insulin receptor substrate-1 (IRS-1) and insulin receptor ...
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Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... unknown. Insulin signaling plays a key role in the regulation of glucose ...of insulin signaling pathways could be a potential contributor to acute hyperglycemia after ...and insulin levels were ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
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