Insulin receptor substrate (IRS)-2
Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... the insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism in colorectal cancer (CRC) susceptibility, we conducted a comprehensive meta-analysis, which included 5,220 ...
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Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
... Type 2 diabetes affects ...(1, 2). Most disease models point to obesity as an important cause of type 2 diabetes, because of its association with skeletal muscle insulin resistance and ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin ...normal ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... Genomic DNA samples were extracted from peripheral blood lymphocytes of patients using TIANamp Blood DNA kits (Tiangen Biotech CO., LTD. Beijing, China). DNA concentration and quality were assessed using absorbance ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... in IRS-2 did however lead to a substantial impairment of NMDA receptor-mediated short-term (STP) and long-term potentiation (LTP) in Schaffer collateral-commissural ...Ca 2+ are necessary to ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... Through global gene deletion, we and others have previously implicated Irs2 in the regulation of β cell function and peripheral glucose metabolism and the central regulation of energy homeostasis (10, 11, 19, 22). These ...
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Original Article MicroRNA-126 acts as a tumor suppressor in glioma cells by targeting insulin receptor substrate 1 (IRS-1)
... for 2 h with 5% non-fat dry milk in Tris-buffered saline containing ...anti-human IRS-1 (1:1000, Santa Cruz, USA), mouse monoclonal anti-human phospho-Akt (p-Akt) (Ser473) (1:100, Cell Signaling, US- A), ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... in IRS-1 is associated with reduced insulin ...type 2 diabetes mellitus and insulin ...mutated IRS-1 gene is associated with dyslipidemia ...influenced insulin sensitiv- ity by ...
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The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects
... The IRS-1 poly- morphisms has been linked to high platelet reactivity in coronary artery disease (CAD) patients with type 2 diabetes mellitus (T2DM) [10, ...that IRS-1 polymorphism genotype Gln192Arg ...
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Glucocorticoid regulation of insulin receptor and substrate IRS 1 tyrosine phosphorylation in rat skeletal muscle in vivo
... glucocorticoid-induced insulin resistance might originate from abnormalities in insulin receptor signaling, we investigated the effects of glucocorticoids on in vivo tyrosine phosphorylation of the ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... whether IRS is an in vivo substrate for Pim protein kinases, MEF cells derived from wild type (WT) and triple knockout of Pim1, Pim2 and Pim3 (TKO) FVB mice were ...Pim1, 2 and 3 by siRNAs in ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... RNA isolation, cRNA preparation, and array hybridiza- tion. WT mice aged 4–6 weeks displaying normal fast- ing and random-fed insulin and blood glucose levels were starved overnight, anesthetized in the morning by ...
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Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
... 55). IRS-2 has also been shown to be overexpressed in human pancreatic cancer cell lines (34), and this may lead to deregulation of the PI 3-kinase/Akt pathway in these ...
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Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice
... Moreover, insulin and insulin-like growth factor cellular signaling were differen- tially altered in ovarian cells from women with PCOS, but after TZD treatment cell signaling was similar to cells from ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Five hundred eighty-three patients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition Text Revision criteria for MDD were recruited from the outpatient department of Shanghai Mental Health ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in ...
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Differential regulation of insulin receptor substrates 1 and 2 (IRS 1 and IRS 2) and phosphatidylinositol 3 kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
... of insulin action with increasing evidence of a complex signaling network using alternative or complementary pathways and multiple molecu- lar isoforms of key signaling molecules ...of IRS-2 (4PS) ...
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