Intensive Insulin Therapy
Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta analytic data
... evaluating intensive insulin therapy (IIT) in critically ill patients grouped randomized controlled trials (RCTs) by type of intensive care unit ...
7
Effect of rosiglitazone on inflammatory cytokines and oxidative stress after intensive insulin therapy in patients with newly diagnosed type 2 diabetes
... mono- therapy, no statistically significant results were ...Continued insulin aspart treatment after the intensive insulin therapy did not change TNF-α levels in T2DM patients, which ...
9
Acute intensive insulin therapy exacerbates diabetic blood retinal barrier breakdown via hypoxia inducible factor 1α and VEGF
... of intensive insulin ...acute insulin-induced VEGF increases appear to be eventually outweighed by the chronic beneficial effects of tight blood-glucose ...long-term insulin therapy ...
12
Intensive insulin therapy versus plasmapheresis in the management of hypertriglyceridemia induced acute pancreatitis (Bi TPAI trial): study protocol for a randomized controlled trial
... Plasmapheresis is relatively expensive and labor in- tensive and is associated with complications. Intensive insulin therapy costs much less than plasmapheresis. Researchers calculated that the ...
5
Abnormal meal carbohydrate disposition in insulin dependent diabetes Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy
... concentrations (252 +/- 33 and 452 +/- 31 mg/dl) of diabetic subjects when insulin deficient were decreased by intensive insulin therapy to values (82 +/- 6 and 193 +/- 10 mg/dl, P less than ...
8
Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy?
... that intensive insulin therapy reduced mortality in selected surgical critically ill patients, lowering of blood glucose levels has been recommended as a means of improving patient ...using ...
5
Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study
... that intensive insulin therapy (IIT) aimed at blood glu- cose levels between 80 and 110 mg/dl, significantly reduced the electrophysiological incidence of CIP/CIM and also the need for prolonged ...
12
The Effect Of Diet Composition On Weight Gain in Obese, Type 2 Diabetes Patients Receiving Intensive Insulin Therapy
... and insulin dose (p = ...in intensive insulin ...levels, insulin dose and hypoglycemia events were not statically ...starting insulin as a last measure in controlling their diabetes and ...
6
Intensive Insulin Therapy Has No Effect on Mortality and Morbidity in Cardiac Surgery Patients: A Meta Analysis
... either intensive insulin therapy (IIT) (maintain glucose < 120 mg/dl) or conventional insulin therapy (CIT) (<200 mg/dl) with conflicting ...(LOS), intensive care unit ...
11
Intensive insulin therapy protects the endothelium of critically ill patients
... with insulin during critical illness protects the endothelium, mediating prevention of organ failure and ...study, intensive insulin therapy lowered circulating levels of ICAM-1 and tended to ...
11
Comparison of a nurse initiated insulin infusion protocol for intensive insulin therapy between adult surgical trauma, medical and coronary care intensive care patients
... on insulin infusion taking into account the type of ICU and the serial aspect of the ...underwent insulin infusion for more than 100 hours had their last measure truncated at 100 ...
9
Intensive insulin therapy and mortality in critically ill patients
... Harborview Medical Center is a 374-bed municipal medical center affiliated with the University of Washington, Seattle, WA, and the only Level 1 trauma center in a five-state area (Washington, Wyoming, Alaska, Montana, ...
10
How does blood glucose control with insulin save lives in intensive care?
... of insulin in the critically ill Improvement of dyslipidemia. Insulin exerts other metabolic effects besides the control of blood ...by intensive insulin therapy, with almost complete ...
10
Adherence in adults with type 1 diabetes mellitus correlates with treatment satisfaction but not with adverse events
... of intensive insulin therapy ...CSII therapy does not seem to be negatively influenced by a higher frequency of self-monitoring of morning fasting and before meal ...
10
Diabetes: a pragmatic therapy with a goal to prevent end stage kidney disease and dialysis
... agents, insulin injections, or a combination of ...with intensive insulin therapy can prevent diabetic complications [7-10], but no systematic studies were done to unequivocally show that ...
13
Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial
... that intensive insulin therapy does not have a beneficial effect in critically ill patients and that it increases the risk of serious adverse events related to hypoglycemia; in the Normoglycemia in ...
9
Original Article Effects of stress hyperglycemia on cardiac function and prognosis in critical patients of ICU
... of insulin secretion and increased plasma free fatty acids, which resulted in membrane dam- aged, calcium overload, myocardial contractili- ty ...after intensive insulin therapy, such as, ...
7
Pitfalls in Outpatient Diabetes Management and Inpatient Glycemic Control
... either intensive insulin therapy intravenously with a target glucose of 80–110 mg/dl or conven- tional therapy with a target glucose of 180–200 ...mg/dl. Intensive insu- lin ...
7
Does tight glycemic control improve outcomes in pediatric patients undergoing surgery and/or those with critical illness?
... between two major studies investigating tight glucose management in adults has led to unclear objectives, and in many ways has raised more questions than it has solved. A distinct lack of well designed, prospective RCTs ...
11
Systemic glucose variability predicts cerebral metabolic distress and mortality after subarachnoid hemorrhage: a retrospective observational study
... Our study has a number of important limitations. First, we were not able to analyze the temporal relation between the development of metabolic distress and glycemic vari- ability, which limits any inference of causality. ...
8