Interferon-stimulated genes
Acute BVDV infection inhibits expression of interferon-stimulated genes during pregnancy recognition in bovine endometrium
... many interferon stimulated genes (ISGs) ...by interferon tau (IFNT), which is a Type I ...endometrial genes which were significantly differentially expressed during IFNT-initiated ...
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Induction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human b cells; relevance to cellular transformation.
... 255 genes that were differentially expressed between EBV and CD40L/IL-4 ...blasts. Genes which were more highly expressed in EBV blasts were substantially and significantly enriched for a set of ...
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Expression of Herpes Simplex Virus ICP0 Inhibits the Induction of Interferon-Stimulated Genes by Viral Infection
... of interferon-stimulated genes. Induction of these genes was significantly greater at multiplicities of infection (MOI) of 10 PFU/cell or greater, and the resulting antiviral effect was only ...
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Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State
... of interferon-stimulated genes (ISGs), such induction was not produced in MDCs, in which a sharp decrease in ISG- and CXCR3-binding chemokines was ob- served, lessening trans-infection of CD4 ...
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Transcriptional Activation of Interferon-Stimulated Genes but Not of Cytokine Genes after Primary Infection of Rhesus Macaques with Dengue Virus Type 1
... other genes with known or unknown antiviral function (cig5 or viperin, CKCL10, and ep- ithelial-stromal interactor 1 ...selected genes of each group is shown in Fig. 3A. Some of these genes (ISG15, ...
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A Short Hairpin RNA Screen of Interferon Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response
... seven genes are established components of innate immune recognition and signaling molecules (PKR, IRF3, IRF9, JAK2, STAT2, TLR3, and ...these genes are required for control of WNV infection in mice or ...
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Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products.
... The transcriptional induction of ISGs seen after viral infection could be due to the action of a newly made viral or cellular protein even including interferon itself.. Therefore transcr[r] ...
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Interferon-stimulated genes—essential antiviral effectors implicated in resistance to Theiler’s virus-induced demyelinating disease
... Type I IFN signal transduction is initiated by their cell surface receptors, IFN alpha and beta receptors (IFNAR)1 and 2, which are linked to janus kinase 1 (JAK1) and tyro- sine kinase 2 (TYK2). These two tyrosine ...
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Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes
... presence of IFN- ␣ /  in 293T cells. Many viruses encode an- tagonists that inhibit various points in the IFN signaling path- way, ultimately preventing synthesis of ISGs (31). The activa- tion state of STAT1, the ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... IFN-␣/ genes via the ISRE enhancer (18, 26, ...ISRE-containing genes di- rectly by the virus infection pathway (15, 25, 28, 31, 45, 46), one would have expected that most of the ISGs were also regulated ...
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Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes
... The requirement for IFNAR signaling for the induction of IFN-␣5, -14, -16, and -21 was dependent on the virus concentration; in cultures infected at the lower MOI, these subtypes were in[r] ...
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Reduced sputum expression of interferon-stimulated genes in severe COPD
... IFN-stimulated genes (ISGs) supposed to mediate the cellular response to IFN by assessing three genes involved at different steps of intracellular viral ...
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Mutations in CECR1 associated with a neutrophil signature in peripheral blood
... of interferon stimulated genes (ISGs) have been described previously ...mean interferon score of the controls plus two standard deviations above the mean (+2 SD) was ...Neutrophil-expressed ...
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INDUCION, MODE OF ACTION AND APPLICATIONS OF INTERFERON FOR TREATMENT OF VARIOUS HUMAN DISEASES: A REVIEW
... of interferon stimulated genes that code for anti- viral ...induce interferon stimulated genes, type 1 with alpha and beta, type 2 includes only gamma and type 3 with only lambda ...
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Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways
... of interferon signaling genes was strongly upregulated in AblPP/tTA mouse forebrain at both 2 and 4 weeks off ...for interferon signaling genes in AblPP/tTA ...of genes downstream of ...
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Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
... Objective: Type I interferons (IFN) have important roles in many immune-mediated inflammatory diseases (IMIDs) and are a relatively new therapeutic target. Direct detection of type I IFNs has proved challenging, thus ...
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Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice
... The interferon-stimulated genes (ISGs) ISG56 and ISG54 are strongly induced in cultured cells by type I interferons (IFNs), viruses, and double-stranded RNA (dsRNA), which activate their ...
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Peripheral inflammation is associated with remote global gene expression changes in the brain
... the genes that are most robustly differentially expressed, the Affymetrix dataset was reanalyzed using GeneSpring GX analysis software, and the resulting list of significantly regulated genes was compared ...
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IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection
... I interferon (IFN-I) signaling downstream of the IFN-I receptor ...of interferon-stimulated genes and IFN-I and by controlling levels of IRF7, a transcription factor essential for IFN-I ...
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Interferon Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency
... Since US28 attenuates c-fos signaling (25) and STAT1 phosphorylation (Fig. 1E to G), and both HLA-DR and IFI16 are fos and STAT1-responsive genes (44–48), we hypoth- esized that one or both of these mechanisms is ...
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