internal ribosome entry site
Synergistic Internal Ribosome Entry Site/MicroRNA Based Approach for Flavivirus Attenuation and Live Vaccine Development
... ABSTRACT The recent emergence of Zika virus underscores the need for new strat- egies for a rapid development of safe flavivirus vaccines. Using another flavivirus (Langat virus [LGTV]) that belongs to the group of ...
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The Picornavirus Avian Encephalomyelitis Virus Possesses a Hepatitis C Virus-Like Internal Ribosome Entry Site Element
... Avian encephalomyelitis virus (AEV) is a picornavirus that causes disease in poultry worldwide, and flocks must be vaccinated for protection. AEV is currently classified within the hepatovirus genus, since its proteins ...
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Interaction of Translation Initiation Factor eIF4B with the Poliovirus Internal Ribosome Entry Site
... Poliovirus translation is initiated at the internal ribosome entry site (IRES). Most likely involving the action of standard initiation factors, this highly structured cis element in the 5 ⴕ ...
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The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA.
... by internal entry of ribosomes into the 5 * noncoding region ...the internal ribosome entry site (IRES) and may involve host ...
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Conserved structural motifs located in distal loops of aphthovirus internal ribosome entry site domain 3 are required for internal initiation of translation.
... A comparison of picornavirus internal ribosome entry site (IRES) secondary structures revealed the exis- tence of conserved motifs located on loops. We have carried out a mutational analysis ...
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Absence of Internal Ribosome Entry Site-Mediated Tissue Specificity in the Translation of a Bicistronic Transgene
... of surrounding secondary structures and subsequent formation of the 48S preinitiation complex, and scanning to an initiation codon. Picornaviruses are small, positive-stranded RNA vi- ruses that encode a unique ...
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An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene
... 40S ribosome subunit at the 5 ⬘ -most AUG codon that is in an appropriate nucleotide ...60S ribosome subunit is joined to the 40S subunit, and translation ensues ...an internal ribosome ...
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Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.
... the internal ribosome entry site ...the entry of the IRES RNA, since PTB and IRES RNA can be enriched in parallel either in 48S or 80S ribosomal complexes by stage-specific inhibitors ...
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Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution.
... directs internal initiation of translation (32). This region, termed the internal ribosome entry site (IRES), is predicted to form extensive secondary structures and contains several ...
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A Peptide Derived from RNA Recognition Motif 2 of Human La Protein Binds to Hepatitis C Virus Internal Ribosome Entry Site, Prevents Ribosomal Assembly, and Inhibits Internal Initiation of Translation
... (HCV) internal ribosome entry site (IRES) and stimulate ...of internal initiation of translation of HCV ...in ribosome assembly at the HCV IRES and also provides the basis for ...
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Mechanism of Initiation Site Selection Promoted by the Human Rhinovirus 2 Internal Ribosome Entry Site
... initiation site usage on the human rhinovirus 2 internal ribosome entry site (IRES) has been examined in a mixed reticulocyte lysate/HeLa cell extract ...initiation site for ...
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Identification of an Intercistronic Internal Ribosome Entry Site in a Marek's Disease Virus Immediate-Early Gene
... In this study, we have identified an internal ribosome entry site (IRES) from the highly infectious herpes- virus Marek’s disease virus (MDV). The IRES was mapped to the intercistronic region ...
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Unique Characteristics of a Picornavirus Internal Ribosome Entry Site from the Porcine Teschovirus-1 Talfan
... RNA is linked to a small virus-encoded peptide termed VPg (or 3B). The 5⬘ untranslated regions (5⬘UTRs) vary from about 600 nucleotides (nt) to 1,300 nt among different picornaviruses and include multiple AUG codons that ...
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An internal ribosome entry site element directs the synthesis of the 80 kDa isoforms of protein 4.1R
... linear ribosome scanning process by directly recruiting the ribosome and positioning it at the start codon through internal ribosome entry site (IRES) ...
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An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression
... The expression of epidermal growth factor receptor (EGFR/ERBB1/HER1) is implicated in the progress of numerous cancers, a feature that has been exploited in the development of EGFR antibodies and EGFR tyrosine kinase ...
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Cytoplasmic Expression of mRNAs Containing the Internal Ribosome Entry Site and 3′ Noncoding Region of Hepatitis C Virus: Effects of the 3′ Leader on mRNA Translation and mRNA Stability
... HCV internal ribosome entry site linked to a luciferase coding region, followed by different 3 ⴕ noncoding regions, were expressed in the cytoplasm of cultured cells by T7 RNA ...
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Duck Hepatitis A Virus Possesses a Distinct Type IV Internal Ribosome Entry Site Element of Picornavirus
... he internal ribosome entry site (IRES) elements have the func- tion to direct cap-independent internal initiation of protein synthesis, which is mechanistically quite different from the ...
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A Dormant Internal Ribosome Entry Site Controls Translation of Feline Immunodeficiency Virus
... internal ribosome entry site (IRES) located within the 5 ⬘ UTR of the genomic RNA (2, 13, ...of internal ribosome entry is mediated by the IRES structure (28, 35, 42) with ...
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Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence
... the internal ribosome entry site (IRES) in the 5 ⴕ -nontranslated region, were found to be involved in the observed attenuation phenotype in ...
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Mutational Analysis of the GB Virus B Internal Ribosome Entry Site
... by internal entry of ribosomes on GBV-B ...an internal ribosome entry site (IRES) bounded at its 5 ⴕ end by structural domain II, a location analogous to the 5 ⴕ limit of the ...
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