Intervertebral disc degeneration (IVDD)
Reactive Oxygen Species Over Production and Superoxide Dismutase Exhaustion Promoting the Intervertebral Disc Degeneration
... of Intervertebral Disc Degeneration (IVDD) by restraining the metabolism and damaging the cell matrix, but the specific process is not yet well ...of IVDD mouse ...and ...
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Lumbar intervertebral disc degeneration and related factors in Korean firefighters
... lumbar intervertebral disc degen- eration, including obesity, 13 14 smoking, 15 medical condi- tions such as diabetes and dyslipidaemia, 13 16 bone mineral density, 18 occupation 13 19 and sport, 13 19 20 ...
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Stem cell horizons in intervertebral disc degeneration
... Abstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and ...the intervertebral disc, and the ...
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Review Article Clarifying the nomenclature of intervertebral disc degeneration and displacement: from bench to bedside
... pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and ...physicians. Disc herniation, termed as intervertebral disc ...
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Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration
... Disc degeneration is the most common cause of back pain in adults and has enormous socioeconomic ...moderate disc degeneration, where a potential for regeneration still ...the ...
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Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration
... IVD degeneration by interactions with the proinflammatory cyto- kines ...of disc degeneration by downregulating catabolic factors, including proinflammatory cytokines and matrix-degrading enzymes, ...
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Increased caveolin 1 in intervertebral disc degeneration facilitates repair
... different degeneration grades, and human and canine CLCs were silenced for caveolin-1 and/or supple- mented with caveolin-1 scaffolding domain (CSD) pep- tide in vitro to determine the (regenerative) effect of ...
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The role of interleukin 1 in the pathogenesis of human Intervertebral disc degeneration
... IVD degeneration and the cartilage changes in osteoarthritis, there has been relatively little inter- est in exploring the possibility that the disease processes involved in IVD degeneration might be driven ...
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The role of interleukin 1 in the pathogenesis of human intervertebral disc degeneration
... with degeneration, no such increase was seen in the numbers of cells with immunopositivity for ...in disc degenera- tion, with a loss in the balance of IL-1 agonists to antagonists, allowing IL-1 to elicit ...
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Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography
... same intervertebral disc spaceswere available, data sets were obtained on the same day and the dogs were suspicious of having spinal cord ...IVD degeneration in non- contrast CT (using a ...
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... Our data demonstrate that TNF-α also upregulates IL-1 β and IL-1Ra genes, but not IL-1 α or IL-1R1, whereas IL-1β upreg- ulates TNF- α and TNF-R2. We have also previously shown that IL-1β upregulates itself and IL-1α ...
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Serum lipid levels are positively correlated with lumbar disc herniation—a retrospective study of 790 Chinese patients
... lumbar disc degeneration (LDH) and High-TG or borderline High-LDL-C predicted a higher incidence of ...of intervertebral disc degeneration (IVDD) disease by controlling serum ...
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Quantitative Molecular MRI of Intervertebral Disc Degeneration
... the intervertebral disc (IVD) is the most common cause of back-related disability among North American ...IVD degeneration, especially its biomolecular aspect, is poorly understood in an in vivo ...
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Inpatient gradual diagnostics and its relevance for determining treatment strategies in lumbar back pain
... Moderate intervertebral disc degeneration was observed at L3/4 and L5/S1 (Pfirrmann grade 3), advanced degeneration at L4/5 (Pfirrmann grade 4-5), and a neuroforaminal stenosis on the right ...
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Landscape of RNAs in human lumbar disc degeneration
... Accumulating evidence indicates noncoding RNAs (ncRNAs) fine-tune gene expression with mysterious machinery. We conducted a combination of mRNA, miRNA, circRNA, LncRNA microarray analyses on 10 adults’ lumbar discs. ...
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Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy
... to intervertebral disc ...for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the source of ...treat ...
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Radiological exploration on adjacent segments after total cervical disc replacement with Prodisc-C prosthesis
... maintaining the biomechanical environment, which could be impaired by unsuitable fixation, prosthesis subsidence, and implant loosening then lead to ASD [22]. Hwang et al. [23] found that increased C2–C7 LOR would reduce ...
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Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index
... histologic degeneration score (HDS) [31] as described ...matrix degeneration (Figure 1b), the formation of clefts and tears (Figure 1c) and mucoid matrix changes (Figure ...
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Discogenic pain: Who cares?
... target disc in order to test its sensitivity to gradually increasing pres- ...adjacent disc with- out concordant ...to disc stimulation due to other factors, as psychometric variables or high con- ...
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Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration
... the disc cells appeared to be able to retain the beads that they had ingested better than the committed phagocytes, in which the number of beads internal- ised decreased with time, perhaps due to subsequent extru- ...
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