intracellular domain
EGFR protein expression using a specific intracellular domain antibody and PTEN and clinical outcomes in squamous cell lung cancer patients with EGFR-tyrosine kinase inhibitor therapy
... Materials and methods: This retrospective study included 67 SCCL patients with obtainable lung cancer tissue and records on EGFR-TKI treatment response and survival. EGFR protein expression in lung cancer tissue was ...
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<p>Notch Intracellular Domain (NICD) Expression and Clinical Manifestations of Second Primary Tumor at Esophagus in Patients with Head and Neck Squamous Cell Carcinoma</p>
... Introduction: Second primary tumor (SPT) is a major factor that affects the survival of head and neck squamous cell carcinoma (HNSCC) patients, and the esophagus is a common site. Detection of SPT is essential for ...
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Characterization of CD44 intracellular domain interaction with RUNX2 in PC3 human prostate cancer cells
... More recently, studies have identified CD44 cleavage product to be important factor regulating transcription of metastatic target genes. In breast cancer cells, sequential cleavage of CD44 resulted in nuclear ...
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Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University
... This results in the activation of the receptors kinase domain leading to cross-phosphorylation of tyrosine residues on the intracellular domain of the receptor providing a start for the [r] ...
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The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry
... extracellular domain (ECD) composed of two Ig-like domains (D1 and D2), a transmembrane domain (TM), and an intracellular domain (ICD) ...PDZ domain and the clath- rin adaptor protein ...
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
... the intracellular domain (ICD) of Frazzled (Fra), the Drosophila ortholog of the conserved guidance receptor Deleted in Colorectal Cancer (DCC), functions as a transcription factor to control axon ...
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Molecular docking and interactions of pueraria tuberosa with vascular endothelial growth factor receptors
... VEGFR1 intracellular domain more strongly than the ...in intracellular domain VEGFR1 and interestingly, both, puerarone and most of the inhibitors interacted with ...the intracellular ...
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Rho and Ras GTPases in semaphorin mediated neuronal development
... similar domain structures with FARP2, they two have distinct functions in triggering the exchange of GDP to GTP; FARP2 is a specific Rac1 GEF [21], while FARP1 is a GEF for Rho ...the intracellular ...
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Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation
... Notch signaling between neighboring cells critically controls cell fate decisions in all metazoans (1, 2). In mammalian cells, engage- ment of the Notch receptors (Notch1–4) by the ligands (Jagged1 and -2 and Delta-like ...
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Notch and the Awesome Power of Genetics
... Notch intracellular do- main: they inserted a GAL4 DNA- binding domain moiety into the intracellular domain of an otherwise intact Notch protein and looked for transcriptional activation of a ...
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The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis
... Notch proteins are large transmembrane receptors that become activated by transmembrane ligands of the Delta/Serrate/Lag-2 (DSL) family [reviewed by Kopan and Ilagan (2009)]. Ligand binding unfolds a protective ...
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Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma.
... and intracellular domain (MET- 79) as the initiation codon for truncated Notch2 protein de- spite the fact that it is located downstream of MET-env: (i) the construct D env-FeLV/N2-B-myc, which lacks ...
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A REVIEW ON RECEPTORS
... extracellular domain of such receptors includes the binding site for the signal, while the intracellular domain activates intracellu- lar signaling cascades after the signal ...
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Notch1 binds and induces degradation of Snail in hepatocellular carcinoma
... Notch1 intracellular domain; OPA: polyglutamine tract; pAb: polyclonal antibody; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PEST: proline-: glutamic acid-: serine- and threonine-rich ...
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6202.pdf
... mucin domain (Thaxton and Bhat 2009). The intracellular region of NF186 contains an FIGQY motif (Garver, Ren et ...the intracellular domain responsible for binding AnkG, further reinforcing ...
171
Receptor tyrosine kinase signaling pathways: a review
... extracellular domain of the FGFRs inducing FGFR dimerization and transphosphorylation of intracellular tyrosine residues and activation of multiple downstream signaling proteins in the same manner as ...
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The insulin receptor and the molecular mechanism of insulin action
... This was further validated by the cDNA cloning, which indicated that the intracellular domain of the a-subunit of the insulin receptor is highly homologous with several other tyrosine pr[r] ...
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The Epstein-Barr virus glycoprotein 110 carboxy-terminal tail domain is essential for lytic virus replication.
... tail domain of either 104 (gp110) or 109 (gB) amino acids ...tail domain of gp110 were constructed by removal of 16, 41, or 56 amino acids from the carboxyl-terminal tail domain of ...
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TYROSINE KINASE AS TARGET FOR CANCER TREATMENT
... domain. Only the left most portion of STI- 571 is found where the adenine base of ATP normally binds. The rest of the compound penetrates further into the hydrophobic core of the kinase, inserted between the ...
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The Biological Actions and Mechanisms of Brain Derived Neurotrophic Factor in Healthy and Disordered Brains
... BDNF promotes alternatively the growth or pruning of the axons intracellular mechanisms, which depend on the extent of the activity of TrkB or p75NTR receptors. These mechanisms must feed into the cytoskeletal ...
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