intracellular signalling
The effects of physiological acidosis on skeletal muscle mitochondrial function, ROS balance, and intracellular signalling
... Adult male Wistar rats (3 month old, n=24) were used to study the effects of altering extracellular pH on soleus muscle contractile function, pH, lactate production, and intracellular signalling for ...
224
Glucosamine affects intracellular signalling through inhibition of mitogen activated protein kinase phosphorylation in human chondrocytes
... Imbalance between catabolic and anabolic factors in OA leads to degradation of articular cartilage. Catabolic factors include proinflammatory cytokines IL-1β and tumour necrosis factor-α, which stimulate ...
9
BDNF stimulated intracellular signalling mechanisms underlie exercise induced improvement in spatial memory in the male Wistar rat
... downstream signalling pathways) is directly responsible for the improvements observed in spatial and object recognition learn- ing, via a mechanism that is distinct from that of environmental enrichment ...the ...
10
Intracellular signalling crosstalk in the differentiation of F9 cells into extraembryonic endoderm
... Three mammalian Hh ligand proteins exist in the mouse, Sonic (SHH), Desert (DHH), and Indian (IHH) [12], and each undergoes auto-proteolysis to form a cleaved (N-terminal), biologically active form, which acts as an ...
72
A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling
... Nanobodies that bind to RFP [20, 21] or GFP [21, 22] are most commonly used in their purified forms for immuno- precipitation and immunocytochemistry. However, they also offer a generic means of targeting in live cells ...
24
Plasmodium yoelii blood stage primes macrophage mediated innate immune response through modulation of toll like receptor signalling
... of intracellular signalling molecules TRAF-6, IRAK-1, and MyD88 were investigated in peritoneal macrophages from mice infected with or without malaria ...
8
Effect of thrombin and alpha-1-antitrypsin on mesenchymal cell proliferation and procollagen production
... the intracellular pathways by which mediators of procollagen synthesis exert their stimulatory ...of signalling pathways procollagen gene expression (Goldstein et at, ...various signalling pathways, ...
281
Mechanisms of Degranulation in Neutrophils
... of intracellular signalling path- ways, including -arrestins, the Rho guanosine triphosphatase Rac2, soluble NSF attachment protein (SNAP) receptors, the src family of tyrosine kinases, and the tyrosine ...
11
Intracellular Ca2+ signalling in secretory cells
... threefold. First, this particular system is probably the one most widely applicable to the various cell types involved in ion and fluid secretion, and is certainly the most intensely studied to date. Second, historically ...
12
Cytoplasmic free Ca2+ is essential for multiple steps in malaria parasite egress from infected erythrocytes
... for intracellular signalling in eukaryotic cells (for review see ...2+ signalling in malaria parasites is well recog- nized but poorly understood; several signalling pathways have been ...
12
Endosome-to-plasma membrane recycling of VEGFR2 receptor tyrosine kinase regulates endothelial function and blood vessel formation.
... Here, we provide evidence that a Rab GTPase-dependent endosome-to-plasma membrane recycling step regulates VEGF-A-dependent intracellular signalling, cell migration, proliferation and angiogenesis. VEGFR2 ...
23
Regulated adhesion as a driving force of gastrulation movements
... by intracellular mechanics and cell surface tension (Krieg et ...in intracellular signalling and cytoskeletal regulation (Hehlgans et ...the intracellular systems (outside-in ...
17
CATECHIN: A TLR4 MEDIATED CHAIN BREAKING INHIBITOR OF SIGNALLING CASCADE IN ENDOTOXIN-INDUCED LIVER INJURY
... Differentiation 2). The complex interaction of these molecules mediates hepatic cell activation and pro- inflammatory cytokine release (Shimazu R et al. 1999). TLR4 by itself does not function as an LPS receptor. To ...
10
Disentangling juxtacrine from paracrine signalling in dynamic tissue
... in Materials and Methods. With three replicated datasets, the solid horizontal lines represent the means of upper and lower bounds, whose precise definitions are given in Materials and Methods, while the shade is defined ...
39
Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events?
... proinflammatory/proapoptotic signalling effects of hydrogen peroxide, both by enabling the degradation of this compound via glutathione peroxidase and by working with glutaredoxin to promote the restoration of ...
5
Multiple RTK pathways downregulate Groucho mediated repression in Drosophila embryogenesis
... EGFR-dependent signalling, and this modification leads to the downregulation of its repressor capacity (Hasson et ...EGFR signalling can thus simultaneously override an entire group of repressors, affecting ...
9
A Review of Maximizing Muscle Building Capabilities with Anabolic Enzymes
... Massive effects have been produced from just physical training alone. Now, advances in science have exposed the potential of performing procedures that alter genetic factors thus accelerating muscle growth. There is much ...
14
The Role of GABA Signalling in Lung Macrophage Immune Response
... TLR signalling, when accompanied by ligation of Fc gamma receptor (FCγR) results in M2b phenotype that is characterized by arginase-1 upregulation along with TNF-α and IL-10 secretion (Anderson et ...
118
Brassinosteroid signalling
... Microarray analyses showed that BR and auxin also activate overlapping sets of genes, while genetic and physiological studies showed synergistic and interdependent interactions between the two hormones in a wide range of ...
6
Sexual signalling in an artificial population: When does the handicap principle work?
... sexual signalling system could be kept ...sexual signalling case, perhaps males are signalling their quality ...the signalling system would be vulnerable to blung: all males would come ...
12