Invariant chain
The interaction of invariant chain-derived peptides (CLIP) with mouse class II MHC molecules
... CD4 complementary DNA complete Freund's adjuvant class II MHC transactivator protein class II MHC- containing vesicle class II MHC- associated invariant chain peptides deionised distille[r] ...
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Hepatitis C Virus-Mediated Inhibition of Cathepsin S Increases Invariant-Chain Expression on Hepatocyte Surface
... Hepatocytes are the main source of hepatitis C virus (HCV) replication and contain the maximum viral load in an infected person. Chronic HCV infection is characterized by weak cellular immune responses to viral proteins. ...
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Decreased HLA DR antigen associated invariant chain (CD74) mRNA expression predicts mortality after septic shock
... compartment. During this stage, CD74 is broken down in stages by proteases called cathepsins, leaving only a small fragment known as CLIP (class II associated invariant chain peptide), which maintains ...
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Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
... MHC class I molecules. CD4 T cells detect extracellu- lar pathogens or self-proteins that have been processed in the endocytic compartment and that are presented on MHC class II molecules. MHC class II antigen ...
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Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
... dideoxynucleotide chain termination method (United States Biochemical), and a search of GenBank with a BLAST search using the National Center for Biotechnology Information website revealed that the third clone did ...
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Shared promoter elements between a viral superantigen and the major histocompatibility complex class II-associated invariant chain.
... H chain, the invariant chain, and major histocompatibility complex class II, suggesting a coordinate regulation of expression of these various B-cell-specific genes and indicating a possible ...
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Competition Model for Upregulation of the Major Histocompatibility Complex Class II-Associated Invariant Chain by Human Immunodeficiency Virus Type 1 Nef
... The human immunodeficiency virus type 1 (HIV-1) Nef protein is critical for efficient pathogenesis and progression to AIDS (25). How Nef causes this is unclear, but missorting of cellular membrane proteins may play a key ...
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Requirement for endocytic antigen processing and influence of invariant chain and H 2M deficiencies in CNS autoimmunity
... To examine whether endocytic processing of native MOG is required for presentation of the dominant encephalitogenic determinant, p35-55 23, we first tested whether splenic APCs from wild[r] ...
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Original Article Design of a ProDer f1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy
... the invariant chain (Ii), a type II integral membrane protein, acts as a chaperone for preventing self-peptide binding to MHC II in the endoplas- mic reticulum (ER) [18, ...II-associated invariant ...
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DNA Vaccine Construct Incorporating Intercellular Trafficking and Intracellular Targeting Motifs Effectively Primes and Induces Memory B- and T-Cell Responses in Outbred Animals
... bovine invariant chain (25), designated IC, was added in-frame at the 5⬘ end of BVP22 by overlap extension PCR (22) with the following primers: ICBVP22 Fwd 1 (5 ⬘ -ATAGATATCATGGAAGACCAGCGTGACCT ...
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Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
... amygdala (CeA) and the dorsal vagal complex (DVC). Our study demonstrates the increased expression of mRNAs specific for several inflammatory markers in these regions including the inflammatory cytokine TNF-α and its ...
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Importance of lysosomal cysteine proteases in lung disease
... Endosomal proteolysis directs the efficiency and character of major histocompatibility complex (MHC) class II-depen- dent antigen presentation by fulfilling two important roles: generation of antigenic epitopes and ...
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Antigen processing pathways in transplantation
... associated invariant chain peptide from MHC class II-CLIP complexes in endosomes, at an acidic pH optimum, and facilitates the binding of antigenic peptides (Denzin et a l l ...
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Invariant triple products
... We will now show that if there is an open orbit, then there are no invariant distri- butions supported on lower-dimensional orbits. For this, it suffices to consider the case G = SO 0 (d, 1). For simplicity, we only ...
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Vol 2017
... Invariant Finsler structures on homogeneous manifolds is one of the interesting subjects in Finsler geometry which has been studied by some Finsler geometers, during recent years(for example see [2], [3], [4], ...
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DA via Markov modeling is that the estimated DA is actually
... An important limitation of estimating DA by Markov modeling is that the estimated DA is actually an upper bound of DA (UDA) that contains the actual one. Since boundary partitions of UDA are not completely placed in ...
5
Three Clifford Algebras for Four Kinds of Interactions
... We have three reasons for enlarging the group of invariance from SL ( 2, ) into Cl 3 * . First this enlargement is possible, which is surprising, because formulas (7) are satisfied with any M. Next the condition det ( ...
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Completeness Problem of the Deep Neural Networks
... Markov chain [11] such that the equilibrium distribution of this Markov chain, p ( a , b ), realizes, as faithfully as possible, the given supervised training ...
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On invariant sets topology
... As an application of the Sections 1 and 2, we give the following fixed point theorems using separation axioms and the concept of orbits related to the function f. For the converse suppos[r] ...
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ON INVARIANT SPEED OF LIGHT
... Therefore, the relative velocity of the entering light to any body will always be equal to the absolute speed of light, regardless of the speed of motion of the considered po[r] ...
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