Ischemic brain injury
Cyclooxygenase inhibition in ischemic brain injury.
... Another mechanism by which COX-2 mediates the neurotoxic effect in ischemic brain injury is through promotion of the cell cycle activity [275;276]. Post-mitotic neurons are devoid of the capacity to ...
36
Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1
... to brain and blood- borne inflammatory mediators are among the major drivers of focal injury following cerebral ...to ischemic brain injury by several possible mechanisms including ...
13
Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death
... Figure 1: Neuronal cell death pathways in the neonatal hypoxic-ischemic brain injury. a. Necroptosis-Ligation of tumour necrosis factor receptor 1 (TNFR1) results in the recruitment of ...
6
Preventing ischemic brain injury after sudden cardiac arrest using NO inhalation
... global ischemic brain injury ...arrest brain injury include excitotoxicity, free radical formation, pathological activation of proteases, and cell death signaling ...of brain ...
6
MG53 permeates through blood-brain barrier to protect ischemic brain injury
... Ischemic injury to neurons represents the underlying cause of stroke to the ...(IR) injury to the brain. MG53 rapidly moves to acute injury sites on neuronal cells to form a membrane ...
12
Deregulation of inflammatory response in the diabetic condition is associated with increased ischemic brain injury
... Chronic inflammation is a salient feature of metabolic disorders and aging-related disease. Because the chronic inflammation is associated with compromised antimicro- bial defenses, delayed wound healing, and impaired ...
9
Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic Ischemic Brain Injury Model Using MRI
... in an HI environment, lactate is increased; this change indicates enhanced anaerobic metabolism. To date, studies that explore the role of lactate in energy metabolism, particularly in neuron recov- ery after ...
8
Excitatory Amino Acids Contribute to the Pathogenesis of Perinatal Hypoxic Ischemic Brain Injury
... observations that intra-cerebral injection of the competitive EAA antagonist arninophosphonoheptanoic acid AP7 attenuated acute ischemic neuronal damage 3 and that preceding deafferentat[r] ...
9
Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury
... induced brain injury was prevented when the animals were given glucocorticoid receptor (GR) antagonist, RU 38486 (40 mg/kg), 1 hour before daily DEX treatment ( P < ...
11
Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats
... levels in hippocampus at 3-4 weeks old in rat brain tis- sue and hippocampus [16,40,41]. The roles of GLT1 in immature brain remained unclear. In human premature infant, expression of EAAT2 was observed in ...
10
Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest
... The acute post resuscitative phase of HIBI is characterized by a “no reflow” phenomenon resulting in persistent cerebral oligemia despite restoration of cardiac output. No reflow, in part, stems from diffuse ...
5
Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
... 44. Kilic E, Kilic U, Reiter RJ, Bassetti CL, Hermann DM. Tissue- plasminogen activator-induced ischemic brain injury is reversed by melatonin: role of inos and akt. J Pineal Res. 2005;39:151–155. ...
7
Expression Analysis of MiR 124 in Experimental Cerebral Hypoperfusion
... DOI: 10.4236/jbm.2018.65002 10 Journal of Biosciences and Medicines ological processes including differentiation, morphogenesis, proliferation and apoptosis. However, recent researches have also found that this ...
6
A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury
... neural injury [29–32]. Reportedly, progesterone treatment following brain ischemia in rodents has provided neuroprotection against ischemic brain injury [33, 34], suggesting the pos- ...
9
Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke
... in ischemic brain injury, recent findings demonstrate that B lymphocytes play a heterogeneous role in the adap- tive immune response to stroke ...ischemia/reperfusion injury [46, ...the ...
14
TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury
... HI brain apoptosis ...from injury in neonatal HI brains ...of ischemic stroke ...HI brain injury ...hypoxic-ischemic brain in- jury, likely through the mitochondrial ...
13
The potential of erythropoietin to treat asphyxia in newborns
... hypoxic-ischemic brain injury, we can develop new neuroprotective strategies that promote or inhibit specific ...following injury, it is possible that, ultimately, a “cocktail” of therapeutic ...
13
Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia
... traumatic brain injury and cerebral ischemia/reperfusion injury [9, ...hypoxic- ischemic brain ...hypoxic-ischemic brain injury, which showed that pre- treatment ...
15
M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124
... exosomes in each area differed (Figure S7). Previous methods such as fusing the neuron-specific rabies virus glycoprotein (RVG) peptide to MSC-derived exosomes have shown increased target delivery of exosomes to neurons, ...
14
Original Article Cerebrovascular protective effect of combination of Tetradrine and Atorvastatin against cerebral ischemia-reperfusion injury in rats via inhibition of inflammatory mediators
... in ischemic region induced byimmune cells, showed to markedly influence the progression of inflammatory responses in the ...the ischemic/reperfu- sion injury, the concentration of TNF-α and IL-1β ...
7