Isocitrate dehydrogenase (IDH)
Autocrine IFN I inhibits isocitrate dehydrogenase in the TCA cycle of LPS stimulated macrophages
... of isocitrate dehydrogenase (IDH) (2, 3), the enzyme that converts isocitrate to α-ketoglutarate and a key check- point in the TCA ...of Idh mRNA leads to reduced α-ketoglutarate levels ...
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<p>Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma</p>
... bolism. Isocitrate dehydrogenase (IDH) is a key enzyme in the tricarboxylic acid (TCA) ...catalyzes isocitrate to produce alpha-ketogluatarate ( α -KG) and NADPH/CO 2 , and ...
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Prognostic and diagnostic potential of isocitrate dehydrogenase 1 in esophageal squamous cell carcinoma
... The isocitrate dehydrogenase (IDH) family comprise the rate-limiting enzymes in the tricarboxylic acid (TCA) cycle and include 3 members (IDH1, IDH2, and IDH3) that convert isocitrate to ...
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Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
... The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle, which can catalyze the conversion of isocitrate to α-ketoglutarate (KG), thus ...
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Identification, Molecular Cloning, and Evaluation of Potential Use of Isocitrate Dehydrogenase II of Mycobacterium bovis BCG in Serodiagnosis of Tuberculosis
... Diagnosis of tuberculosis is time-consuming and requires infrastructures which are often not available in countries with high incidences of the disease. In the present study, an 82-kDa protein antigen was isolated by ...
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Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas
... of isocitrate dehydrogenase 1 (IDH1) mutations in glioma is one of the major discoveries mediating metabolomics and oncogenesis ...of isocitrate into α-ketoglutarate (α-KG), simultaneously converting ...
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Study of Isocitrate Dehydrogenase 1and 2 Mutations in Adult Egyptian Patients with Denovo Acute Myeloblastic Leukemia, Their Relation to Clinical Characteristics, FLT3/ITD and Nucleophosmin 1 Mutations and Impact on Treatment Outcome
... Background: Acute myeloid leukaemia (AML) is a malignancy that is heterogeneous in nature characterized by genetic abnormalities some of which are established in the diagnosis and prognosis of the disease. An additional ...
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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
... the IDH mutants [17]. IDH wildtype samples were all from ...3 IDH WT lines (HK157, HK301, and HK308) and 3 IDH1 mutant lines (HK213, HK252, and ...
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<p>Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients</p>
... Our results show that IDH1 mutation in gliomas is associated with lower levels of chronic in fl ammation which could account for the improved prognosis in this group of patients. These fi ndings can be explained by the ...
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Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
... by IDH mutations [41], during the progression of the disease, IDH mut cells need to adopt rescue mechanisms that supply the cells with the re- quired basic level of α-KG to remain ...
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Isocitrate dehydrogenase mutations in leukemia
... (57, 58, 62) as well as children (48, 50). In an effort to determine if a larger set of mutant disease alleles can inform outcome in AML, Patel and colleagues performed mutational profiling of 502 AML patients younger ...
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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
... leukocytosis. IDH-DS occurred in about 11% of the patients with a median onset time of 29 days, and could be cured by temporary withdrawal of the drug and adding glucocorticoids and diuretics [34, 62, ...
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Isocitrate Dehydrogenase Is Important for Nitrosative Stress Resistance in Cryptococcus neoformans, but Oxidative Stress Resistance Is Not Dependent on Glucose-6-Phosphate Dehydrogenase
... example, NADPH is consumed in peroxisomes by enzymes such as catalase and uric acid oxidase, that counteract the ROS produced during breakdown of lipids (4, 5, 31). Mitochondria particularly require reductive capability, ...
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THE INHERITANCE OF ENZYME VARIANTS FOR TYROSINE AMINOTRANSFERASE, NADP-DEPENDENT MALATE DEHYDROGENASE, NADP-DEPENDENT ISOCITRATE DEHYDROGENASE, AND TETRAZOLIUM OXIDASE IN TETRAHYMENA PYRIFORMIS, SYNGEN 1
... The F, hybrid clones showed both parental isozymes and an isozyme of intermediate mobility, which is presumed to indicate this enzyme is a dimer.. TAIT (1970) has examined t[r] ...
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<p><em>IDH1</em>-mutated relapsed or refractory AML: current challenges and future prospects</p>
... of isocitrate dehydrogenase 1 (IDH1 mut ), present in 7 – 14% of AML patients, have been discovered recently, opening the door to targeted agents aiming to improve the outcomes in this ...including ...
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<p>Enasidenib in acute myeloid leukemia: clinical development and perspectives on treatment</p>
... cycle, isocitrate dehydrogenase (IDH), leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate ...the IDH enzyme have been shown in preclinical studies to reduce the ...
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Original Article A population-based study of high-grade gliomas and mutated isocitrate dehydrogenase 1
... Abstract: High-grade gliomas have a dismal prognosis, and prognostic factors are needed to optimize treatment algorithms. In this study we identified clinical prognostic factors as well as the prognostic value of ...
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The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets
... in isocitrate dehydrogenase (IDH), BRCA1-Associated Protein 1 (BAP1) and AT-rich interactive domain-containing protein 1A (ARID1A), and novel fusions such as fibroblast growth factor receptor 2 ...
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MR Imaging–Based Analysis of Glioblastoma Multiforme: Estimation of IDH1 Mutation Status
... BACKGROUND AND PURPOSE: Glioblastoma multiforme is highly aggressive and the most common type of primary malignant brain tumor in adults. Imaging biomarkers may provide prognostic information for patients with this ...
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Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats
... Heat shock protein 60 is a mitochondrial protein that involved in protein folding, transport, and protection [34]. It inhibits protein misfolding, maintains mitochon- drial proteostasis, and prevents protein damage [34]. ...
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