klotho gene
Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
... the klotho pro- tein functions as a circulating hormone that represses intracellular signals of insulin and IGF-I ...the klotho-IGF-I-PI3K-Akt-mTOR signal- ing pathway may also be involved in the regulation ...
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The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
... Klotho gene is an aging associated gene discovered by Kuro-o et ...human Klotho gene have been identified [8], among which, the G-395A (rs1207568) SNP in the promoter region of ...
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N-ethyl-N-Nitrosourea (ENU) Induced Mutations within the Klotho Gene Lead to Ectopic Calcification and Reduced Lifespan in Mouse Models
... and klotho ( KL ), which are all part of a phosphate-regulating ...the klotho gene ( Kl ), and DNA sequence analysis identified nonsense (Gln203Stop) and missense (Ile604Asn) Kl mutations in Ecalc1 ...
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Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis
... soluble Klotho proteins (sKlotho) ...of Klotho in blood (4), has a variety of biological activities, such as regulation of energy metabo- ...The Klotho gene is only expressed in organs such as ...
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Review Article α-klotho: a novel regulator in female reproductive outcomes and hormone-related cancer
... Recent studies revealed potential mechanisms of α-KL in tumorigenesis during breast cancer development: 1) α-KL inhibits IGF signaling pathway. α-KL overexpression in MCF-7 cells and MDA-MB-231 cells (transfected with ...
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Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
... in klotho hypomorphic mice is massively ...of klotho expression leads to a dra- matic reduction in the regenerative capacity of skeletal muscle, which reminded us of the phenotype we observed during natural ...
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Aging Syndrome Genes and Premature Coronary Artery Disease
... second gene implicated in progeria is KLOTHO encoding a membrane protein of unknown function shar- ing homology with ...the Klotho locus in mice results in reduced longevity, vascular disease, ...
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Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
... membranous Klotho and through alternative splicing of the Klotho gene and has a unique role in renal calcium and phosphate excretion, inde- pendent of FGF-23 ...progressive Klotho deficiency ...
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Are S-Klotho’s Maximal concentrations dependent on Exercise Intensity and Time in young adult males?
... and Klotho gene expression reduce the risk of cardiovascular events in patients with prior coronary artery disease (CAD), thus, aerobic exercise may decrease the risk of mortality ...
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Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees
... human Klotho gene encodes either a transmem- brane protein or a secreted form ...alpha klotho (α-Kl), functions as an endocrine fac- tor [44, ...However, klotho deficiency causes symptoms of ...
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Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients
... for klotho gene promoter polymorphism ...serum klotho was correlated with verbal fluency after adjusted for age, but not memory or executive ...serum klotho is not an independent risk factor ...
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The role of klotho in chronic kidney disease
... increase klotho expression (Table 1) [14]; these includethe following: (1) ...the klotho gene promoter reduces its activity by 30% to 40%, whereas DNA demethylation increases klotho ex- ...
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Correlation of serum levels of fibroblast growth factor 23 and Klotho protein levels with bone mineral density in maintenance hemodialysis patients
... The Klotho protein is a transmembrane protein encoded by the Klotho ...the Klotho gene developed osteoporo- sis ...the Klotho protein not only decreased the number of osteoblasts but ...
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<em>Klotho</em>, stem cells, and aging
... of klotho transcript arises from the klotho ...Secreted klotho arises from an alternative RNA ...membrane klotho protein encoded by the membrane form of klotho transcript is a ...
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Klotho in chronic kidney disease in Indian population
... stage 5 was similar to that of CKD stage 4; indicating minor contribution of Klotho from other organs as well. A study carried out in elderly (>79 years) populations of Ashkenazi Jewish and Bohemian Czech have ...
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Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β catenin signaling pathway
... suppressor gene, which is highly conserved between human and mouse, with 86 % amino acid identity ...The gene encoded a membrane protein and defect in Klotho gene expression in the mouse that ...
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<p>The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis</p>
... longevity gene, is mostly studied one. 4,5 Klotho is a transmembrane protein that shares sequence homology with family I β ...α Klotho gene that encodes three isoforms of Klotho ...
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Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis
... Whether Klotho and FGF-23 act independently of each other on the cardiovascular system in CKD patients is not ...of Klotho, ...hand Klotho has recently been shown to be associated with PWV, in a ...
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Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-κB
... that Klotho protein inhibited the activation of IRS-1 / PI3K / Akt / mTOR and ERK / p70s6k and downstream signaling pathways in gastric cancer and liver cancer cells, mainly through the inhibition of IGF-1R ...
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Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
... of Klotho deficiency. The Klotho expression may be suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects and possible mechanisms by which Klotho expression is ...
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