Kneading Method
PREPARATION AND CHARACTERIZATION OF MESALAMINE SOLID DISPERSIONS BY KNEADING METHOD
... The purpose of the study was to improve the physicochemical properties of Mesalamine like solubility and dissolution rate by forming solid dispersions with sodium lauryl sulphate (SLS) and Urea (UR) as water-soluble ...
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FORMULATION DEVELOPMENT AND SOLUBILITY ENHANCEMENT OF ROSUVASTATIN CALCIUM TABLET PREPARED BY COMPLEXATION WITH β CYCLODEXTRIN BY KNEADING METHOD
... ABSTRACT: Rosuvastatin is a Dyslipidaemic agent, which acts by inhibiting HMG-CoA reductase enzyme and used in the treatment of hyperlipidemia. But Rosuvastatin calcium (RST) exhibit unsatisfactory dissolution profiles, ...
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DESIGN, DEVELOPMENT AND DISSOLUTION ENHANCEMENT OF SIMVASTATIN WITH POLOXAMER 407 BY KNEADING METHOD
... The aim of the present study was to enhance the solubility and dissolution rate of Simvastatin (SIM) under the frame of improved bioavailability and dissolution rate. Solid dispersion of SIM was prepared by using LBG, ...
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Formulation and Evaluation of Mefenamic Acid Solid Dispersions Employing Starch Citrate-A New Solubility Enhancer
... and kneading method) at 5, 10, 15, 30, 45 and 60 minutes are calculated and dissolution profile for different formulation are given in below figure ...
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Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement
... The 5 mg pure famotidine and 5 mg equivalent weight of famotidine containing SDs prepared by kneading method were added separately in conical flask contain- ing 20 ml of distilled. All mixtures were ...
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Journal of Applied Pharmaceutical Science
... Effects of beta cyclodextrins and Polyethylene glycol on solubility of silymarin were evaluated by phase solubility studies both separately as well as in combination. Solid inclusion complexes of silymarin –β- ...
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Solubility Augmentation of Simvastatin by using the Marvelous Carrier Hydroxy Propyl beta-cyclodextrin: Compatibility Study, Statistical and Spectral Analysis
... In the current generation of formulation development, poor bioavailability associated with poor solubility of drug is a major challenge. It is also a cause of higher therapeutic dose. Solid dispersion is very attractive ...
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Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking
... average ratings it could be concluded that CTZ was successfully complexed in the cavity of β-CD using kneading method, which prevented a contact of CTZ with taste bud receptors. The prepared CTZ, β-CD FDTs ...
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Preparation and Usage of Pre-Gelatinized Starch for Enhancing the Solubility of Water Insoluble Anti-Inflammatory Agent
... Studies were under taken on the preparation and evaluation of solid dispersions of Etodolac with view to develop fast release formulation of Etodolac. Three carriers viz PGS( Potato), PGS (Tapioca) and PGS (Maize) were ...
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STUDIES IN DISSOLUTION ENHANCEMENT OF ATENOLOL USING HP-βCD
... In case of Kneading method showed broadened endothermic peak at 120-155 o c .This may be due to the shifting of characteristic peak of Atenolol which was observed at 154.85 o c, indicates strong interaction ...
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PREPARATION AND EVALUATION OF INCLUSION COMPLEXES OF FELODIPINE
... From the results it is observed that the dissolution rate was increased more by kneading method than by all other techniques. This is because of higher hydrophillicity and wetting property of β- CD and HP ...
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Development of Controlled Release Tablets of Nisoldipine with Improved Pharmaceutical Properties
... by kneading method (KS) and physical mixtures ...by kneading technique were further compressed into tablets by direct compression process using Hydroxy Propyl Methyl Cellulose (HPMC K 100 LV) as drug ...
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FORMULATION AND EVALUATION OF SOLID DISPERSION OF LOPINAVIR BY USING DIFFERENT TECHNIQUES
... solvent kneading method and batch CK 2 was selected for formulation of immediate release tablet because they showed highest increase in the solubility of drug in aqueous solution as compare to pure drug and ...
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New formulation of an old drug in hypertension treatment: the sustained release of captopril from cyclodextrin nanoparticles
... In this report, we have provided detailed physicochemical characterization of inclusion compounds formed through different procedures between CAP and three different CDs, and showed that the kneading method ...
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DESIGN AND DEVELOPMENT OF ORAL DISINTEGRATING TABLET OF SIMVASTATIN BY USING β CYCLODEXTRIN
... The present study deals with the design and development of oral disintegrating tablet of Simvastatin by using β-cyclodextrin with direct compression technique using various superdisintegrants like Crosprovidone, ...
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Formulation and Evaluation of Gliclazide Microspheres
... mixture, kneading method and solvent evaporation ...evaporation method at 1:1 molar ratio has faster dissolution rate when compared with all the other ...
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“Approaches to Improve Atorvastatin Calcium Bioavailability: A Review” by Nagesh C, Vedamurthy Joshi, Abhishek S, Rajeshwari A.G., India.
... Dharmila et.al, were prepared solid dispersions by using modified locust bean gum in modified solvent evaporation method. And other mixtures were also prepared by physical mixing, co-grinding, and the ...
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PREPARATION AND EVALUATION OF TASTE MASKING COMPLEX OF CIPROFLOXACIN HYDROCHLORIDE BY USING INCLUSION COMPLEXATION APPROACH
... using kneading method and was further characterized by DSC and FT-IR ...complexation. Kneading complex showed effective taste masking and at the same time showed no limiting effect on the drug ...in ...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROPERTIES OF BOSENTAN BY INCLUSION COMPLEXATION
... The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical ...
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Solubility enhancement of allopurinol by solid dispersion using sugar carriers
... by kneading method using lactose and mannitol with different ratio of drug and carrier such as 1:1, 1:3, 1:5 and after the formulation all the physiochemical properties were ...dispersions. Kneading ...
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