KO mice
Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
... apoE KO and apoE KO-MNC mice, using wild-type C57 animals as reference ...apoE KO mice ...(apoE KO-MNC: ...apoE KO mice was prevented by MNC therapy (ratios of ...
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Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
... APLP2-KO mice showed normal neuronal morphology and spine density, APP-KO mice revealed a highly reduced dendritic complexity in mid-apical ...APP/APLP2-DKO mice. Mechanistically, using ...
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Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway
... vehicle-treated mice fed with HFD than vehicle-treated mice fed with chow diet (maximal relaxation (Emax) = ...OCN-treated mice fed with chow diet. However, in mice fed with HFD, the OCN ...
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The A2B adenosine receptor protects against inflammation and excessive vascular adhesion
... tom). On the latter, the restrictions sites (ApaL1) used to digest genomic DNA for Southern blot analysis of tail genomic DNA (B) are indicated, as well as the sites for sense (s) and antisense (as) primers used for PCR ...
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Sox9 conditional knockdown reduces chondroitin sulphate proteoglycan expression, increases neuroplasticity, and improves motor function in a mouse model of spinal cord injury
... Sox9 KO mice may improve these endogenous reactive sprouting mechanisms, allowing newly formed collateral sprouts from spared axons traversing the lesion to make functional connections on motor neuron ...
241
Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors
... (WT) mice. Results: The MS paradigm decreased the duration that WT mice stayed in the center area of an open field, but not for motopsin KO mice; however, it decreased the novel object ...
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Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
... cell KO mice were compatible with those in LFD-fed Flox mice (Figure 6, D and ...cell KO mice, an insulin toler- ance test was performed in β cell KO and Flox mice fed an ...
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The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity
... Lpar4-KO mice were examined on ...Lpar4-KO mice was equivalent to that of WT mice (Fig- ure ...Lpar4-KO mice (Supplemental Figure 4). However, Lpar4-KO mice ...
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Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice
... recipient mice that had undergone transplantation with bone marrow from ABCA2 KO ...ABCA2 KO transplanted ...ABCA2 KO macrophages will be needed to investigate the relation between ...
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Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia
... For the acceleration of the onset and development of atherosclerotic plaques, the ApoE KO mice (A group) received a hyperlipidemic diet. Indeed as previously published, introducing the high fat diet results ...
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Abnormalities of hair structure and skin histology derived from CRISPR/Cas9 based knockout of phospholipase C delta 1 in mice
... Nude mice exhibit hairless and congenital athymia by a loss-of-function mutation in the transcription factor Foxn1 gene [17, ...nude mice is caused by insuffi- cient expression of PLCD1 [20, ...
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Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation
... spinophilin-KO mice did not develop sensitization (KO-saline+CTEP vs. KO-cocaine+CTEP p = ...the KO mice, which could lead to the lack of a further ...that mice ...
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Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture
... (KO) mice have significantly fewer neurons with shorter neurite outgrowth than cultures from wild-type (WT) ...apoE KO culture with either purified human apoE2 or with human apoE3 significantly ...
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IL 23 is essential for T cell–mediated colitis and promotes inflammation via IL 17 and IL 6
... IL-10–KO mice and IL-10 × p19–KO mice contained distinct populations that could produce IL-4 or IFN-g (Figure ...IL-10–KO mice had a large number of IL-17–positive ...
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Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
... in mice loaded with OVA-immune complex (IC) than in those loaded with OVA; however, no significant differences were seen in FcgR KO mice [36], suggesting more efficient matura- tion by OVA-IC than by ...
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Site-1 protease–derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability
... PRR KO (RT PRR–KO) mice exhibit a strong autophagic defect in medullary epithelial cells, as characterized by accumulation of autophagosome markers, includ- ing p62 and microtubule-associated protein ...
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Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice
... these mice exhibited increased macrophage ...KORLDLr KO mice ...KORLDLr KO mice compared to WTRLDLr KO mice ...WTRLDLr KO and ABCA1 KORLDLr KO mice to ...
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Type 1 angiotensin receptors on macrophages ameliorate IL 1 receptor–mediated kidney fibrosis
... or KO mice, but not M0 macrophages, upregulated Col I and Ngal mRNA expression in ...Il1r1 KO RTCs, coincubation with M1-conditioned macro- phages from WT or Macro KO animals induced severely ...
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Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice
... both mice and humans ...all mice in the range of 14–20 months were considered “aged” for this ...CFTR KO mice. The main novelty of our findings in aged mice is that CFTR KOs develop ...
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Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy
... (E8) KO mice, the proportion of glycosylation disruption was clearly linked with disease ...αDG, mice with more glyco-positive fibers clearly had a moderate, rather than severe, dystrophic phe- ...
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