Krüppel-like factor 6
Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling
... KLF6: Krüppel-like factor 6; Luc: Luciferase; MAPK: Mitogen activated protein kinase; MCK: Muscle creatine kinase; MEF2: Myocyte enhancer factor 2; MEK: MAP Kinase, ERK Kinase Kinase; ...
9
Krüppel like factor 6 regulates mitochondrial function in the kidney
... identified Krüppel-like factor 6 (KLF6), a zinc finger domain transcription factor, as an essential regulator of mitochondrial function in podocyte ...
16
Krüppel like factor 6 regulates transforming growth factor β gene expression during human respiratory syncytial virus infection
... identified Krüppel-like factor 6 (KLF6) as a critical transcription factor required for TGF-b gene-expression during RSV infection of human lung epithelial ...Although ...
6
Loss of Krüppel like factor 6 cripples podocyte mitochondrial function
... named Krüppel, meaning “crip- ple” ...that Krüppel mutations disrupt Drosophila body segmentation at very early stages of embryogenesis, leading to embryonic lethality ...
5
Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer
... We have demonstrated that KLF8 promotes EMT, migration, invasion and metastasis by repressing E-cadherin and activating MMP2, MMP9, and MMP14 [2, 6, 7]. EGFR is well known to promote breast cancer progression [16, ...
15
Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation
... Here, we identify that KLF4/STAT3 signaling in the podocyte has an essential role in the initiation and progression of aberrant GEC hyperplasia in murine models of RPGN and FSGS. We illustrated this by demonstrating that ...
24
Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter
... lium, krüppel-like factor (KLF) 4 and 5 are expressed in post-mitotic keratinizing suprabasal cells and proliferative less-differentiated basal cells, ...
5
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
... Upon further analysis, low KLF4 mRNA levels were detected in most colon cancers, with the exception of Cases 3 and Case 6 (Figure 3C, normalized to GAPDH). Western immunoblotting confirmed the attenuated KLF4 ...
10
Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
... known to mutate in human beta-thalassemias [1], and restricts megakaryocytic differentiation to the benefit of erythroid differentiation [2]. The EKLF gene dosage is crucial for regulating the surface phenotype and ...
13
The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells
... Krüppel-like factor 4 (KLF4) is a zinc finger transcriptional factor that is highly expressed in differentiated, post-mitotic cells in both gut and skin ...transcriptional factor, KLF4 ...
15
Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice
... tion due to rapid cell turnover [1-3]. High doses of radiation cause apoptosis in crypts, shortening of villi, and even loss of intestinal mucosa. Radiation-induced intestinal injuries are common side-effects of radio- ...
11
Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
... Krüppel-like factor 4 (KLF4) is a member of the zinc- finger class of transcriptional regulators and is required for reprogramming adult fibroblasts into induced pluri- potent stem cells ...
11
Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression
... Human KLF4 cDNA was inserted into the pCDH vector using the primers: F:5-GCGAATTC ATGAGGCAGCCACCTGGCGA-3 and R: 5-GCGGA TCC TTAAAAATGCCTCTTCATGT-3. KLF4cDNA was then amplified by RT-PCR using total RNA from MG63 cells. ...
11
Original Article miR-320 inhibits human coronary artery smooth muscle cell proliferation and migration by targeting Krüppel-like factor 5
... Krüppel-like factor 5 (KLF5) is characterized by a highly conserved interfinger space sequence and has been identified in mammalian [6]. It is generally known that KLF5 regulates a wide ...
9
A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
... Krüppel-like factor 8 (KLF8) belongs to the KLF fam- ily of transcription factors, which shares the similar well- conserved zinc finger DNA-binding domains, and plays a critical role in controlling ...
12
MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
... growth factor binding protein-1 (IGFBP-1)), inflammatory mediators (IL-1, IL-6, IL-8, and TNF-α), and specific extracellular matrix proteins (laminin, type IV collagen, and fibronec- tin) ...
9
Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall
... By contrast, targeted disruption in mice of KLF2 revealed its essential role in programming quiescent phenotype of sing- le-positive T cells and in normal development of the lungs. Hence its alternative denomination of ...
5
Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation
... Considering the potential role of Klf4 in inflammation, we hypothesized that Klf4 may play a role in the upre- gulation of cytokines such as TNF-a, MCP-1 and IL-6. Since there was no significant change in Klf4 ...
20
Krüppel like factor 4 regulates macrophage polarization
... Cox-2 promoter in LPS-treated KLF4-deficient macrophages would correspond to greater transcriptional activation of the Cox-2 gene (Figure 3F). Because activation of the NF-κB pathway is critical for LPS-mediated Cox-2 ...
15
Krüppel like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development
... For embryonic expression experiments, mRNAs encoding ERG, KLF2, DR- KLF2 and EGFP were injected into a single vegetal blastomere of a four-cell stage embryo in 0.4 ⫻ MMR containing 6% Ficoll and cultured ...
11