Krüppel-like transcription factor
Combinatorial Effects of the Glucocorticoid Receptor and Krüppel-Like Transcription Factor 15 on Bovine Herpesvirus 1 Transcription and Productive Infection
... Additional studies were performed to test whether interactions between KLF15 and the GR increased the stability of either protein. Endogenous levels of the GR were not altered dramatically when Neuro-2A cells were ...
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Synergistic Activation of Bovine Herpesvirus 1 Productive Infection and Viral Regulatory Promoters by the Progesterone Receptor and Krüppel-Like Transcription Factor 15
... of transcription (arrow), TATA box, and binding site for VP16/Oct1 complex are indicated as TAATGARAT, and the locations of GRE1 and GRE2 are ...Additional transcription factor-binding sites in the ...
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A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
... the transcription factors are com- monly recognized as direct transcriptional activators, mounting evidence has indicated the key role of tran- scription factors in inducing epigenetic changes in specific regions ...
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Overlapping functions of Krüppel like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells
... pluripotency-associated transcription factors, such as Oct3/ 4, Sox2, Tbx3, Nanog, Esrrb, Gbx2, Nr5a2, Tfcp2l1 and Nr0b1 (Figs 1C and ...associated transcription factors show distinct expression patterns in ...
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Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
... two transcription factors may be equally important in regulating the downstream proinflammatory markers of microglial ...key transcription factor in modulating ...
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Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation
... prostaglandins like PGE2 [34] from arachidonic acid, which is then converted to active prostanoids by synthases ...and Krüppel- like factors was not known until recent studies sug- gested that Cox-2 ...
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Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
... 23). Like other members of the KLFs family, KLF15 protein contains a conserved three-zinc-finger (C2H2) motif in the C-terminal region, which can bind to GC-rich sequences in target gene promoters and regulate ...
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Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter
... Background: Krüppel-like factor 4 (KLF4) is a transcription factor regulating proliferation-differentiation balance of epithelium, and down-regulated in less-differentiated and advanced ...
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Dexamethasone induced Krüppel like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia
... In addition to KLF9, the other 2 members of the KLF family, KLF10 and KLF15, have been shown to regulate hepatic glucone- ogenesis (25, 26). KLF10 was reported to repress gluconeogenesis (male global Klf10-KO mice ...
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Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression
... Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, is an essential regulator in many cellular processes, including differentiation, proliferation, inflammation, ...
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The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells
... Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor that regulates many essential processes, including development and cell differentiation, proliferation, and ...
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Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation
... zinc-finger transcription factors that exert diverse effects on key biologic processes, including tumorigenesis, immune cell activation, and pluripotency (10, ...
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Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4
... Krüppel-like factor 4 (KLF4) is a member of the zinc- finger class of transcriptional regulators and is required for reprogramming adult fibroblasts into induced pluri- potent stem cells ...gene ...
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Krüppel-like factors: Three fingers in control
... basic transcription element- binding protein (BTEB1 or KLF9), 20 or by their physiological responses, such as transforming growth factor-b-inducible early genes 1 and 2 (TIEG1 and TIEG2 or KLF10 and KLF11, ...
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Loss of Krüppel like factor 6 cripples podocyte mitochondrial function
... Krüppel-like factors (KLFs) are zinc finger transcription factors that share homology in three C-terminal zinc finger domains. KLF family members are expressed in most if not all tissues and have ...
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Krüppel like factor 6 regulates transforming growth factor β gene expression during human respiratory syncytial virus infection
... growth factor-beta (TGF) plays a crucial role in asthma ...Kruppel-like factor family of transcription factors are critical regulators of cellular/tissue ...Kruppel-like factor 6 ...
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Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall
... gut-enriched Krüppel-like factor, was initially considered an epithelial-specific trans- cription factor which participated in the differentiation and growth of the epithelium, namely in the ...
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Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
... erythroid transcription factors mRNA expression in patients with acute myeloid leukemia (AML) in the context of cytogenetic and other prognostic molecular markers, such as FMS-like Tyrosine Kinase 3 (FLT3), ...
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Krüppel-like factor 6 (KLF6) promotes cell proliferation in skeletal myoblasts in response to TGFβ/Smad3 signaling
... Regulation of skeletal myogenesis is a complex process. Initially paracrine factors instigate the migration of desig- nated myotome progenitor cells to the dermomyotome re- gion of the somite. These proliferating cells ...
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Krüppel like factor 6 regulates mitochondrial function in the kidney
... the transcription factors that regulate mitochondrial function in podocyte injury remain to be ...identified Krüppel-like factor 6 (KLF6), a zinc finger domain transcription ...
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