Lassa Virus
Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus
... of Lassa virus GP1 due to conformational changes ...choriomeningitis virus (LCMV) in a prefusion conformation (26), the histidines that are homologous to His92 and His93 are in a slightly different ...
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25 Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation
... includes Lassa virus (LASV), lymphocytic choriomeningitis virus (LCMV), Lujo virus, Junin virus, and Machupo ...Ebola virus infection, including fever, headaches, muscle pain, ...
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Role of the C Terminus of Lassa Virus L Protein in Viral mRNA Synthesis
... FIG 1 Influence of L protein mutations on viral RNA synthesis as tested in the Lassa virus replicon system. Transcriptional activity of L protein mutants was measured via Ren-Luc reporter gene expression. ...
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Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin
... infectious Lassa virus (LASV) release signifi- cantly decreased or increased in human cells in which BST-2 was either stably expressed or knocked down, ...fever virus (RVFV) and cowpox virus ...
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TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus
... ABSTRACT Lassa virus (LASV) is an Old World arenavirus responsible for hundreds of thousands of infections in West Africa every ...leukemia virus envelope (Env) for the mucin-like domain served as a ...
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The Lassa Virus Epidemic in Mango, Togo: Therapeutic Route of the First 4 Cases
... [1]. Lassa fever is a viral disease belonging to the FHV group occurring in epidemics, mainly in West Africa due to a virus of the Arenaviridae family: Lassa virus [2], whose first epidemic ...
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THE CAUSE OF AXL PROTEIN IN THE ENTRY OF LASSA VIRUS INTO PERMISSIVE CELLS
... Lassa virus (LV) is a member of the Arenaviridae family, contains a negative- strand RNA genome (Günther and Lenz 2004), and is transmitted via rodents (Garry ...causes Lassa fever disease which is ...
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Lassa virus like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever
... Lassa virus-like particles were generated to contain the major immunological determinants of the virus, resembled native virions structurally, and were immuno- genic in ...against Lassa ...
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Efficient Rescue of Recombinant Lassa Virus Reveals the Influence of S Segment Noncoding Regions on Virus Replication and Virulence
... Lassa virus (LASV), family Arenaviridae, is an enveloped RNA virus (8) which can cause a severe hemorrhagic syn- drome with case fatalities approaching 10 to 20% (13, ...of Lassa fever with ...
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Characterization of Lassa Virus Glycoprotein Oligomerization and Influence of Cholesterol on Virus Replication
... Lassa virus budding from detergent-soluble membrane ar- ...Junin virus, it was recently shown that assembly of GP occurs in detergent-soluble mem- brane microdomains ...for virus infec- tivity ...
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Current Molecular Epidemiology of Lassa Virus in Nigeria
... parameters). The data sets were also analyzed using PhyML software with the following parameters: GTR ⫹ gamma and consensus of 500 bootstrap trees (not shown). The topology of Bayesian and PhyML trees was congruent for a ...
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Identification of Protective Lassa Virus Epitopes That Are Restricted by HLA-A2
... Lassa virus (LASV), a member of the family Arenaviridae, is a rodent-borne pathogen that causes an estimated 200,000 cases of Lassa fever (LF) annually in the West African coun- tries of Nigeria, ...
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An attenuated Lassa vaccine in SIV infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus specific immunity
... Lassa hemorrhagic fever (LHF) is a rodent-transmitted disease that causes more than 300,000 human cases per year in the West African endemic area. Mortality rates are between 15-20% in hospitalized individuals, ...
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Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z
... the Lassa virus matrix protein in a stable, wreath- like dodecameric assembly as presented here illustrates conforma- tional changes required for ...for Lassa virus ...
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Identification of a Novel Consensus Sequence at the Cleavage Site of the Lassa Virus Glycoprotein
... the Lassa virus glycoprotein GP-C is also of high biological ...the Lassa virus Josiah GP-C, paired arginine residues are present at amino acid positions 256 and ...the Lassa ...
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Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection
... by Lassa virus (LASV), is a major public health threat in certain parts of Africa and is characterized by acute hemorrhagic disease and neurological complications (se- ...tions. Virus-induced hearing ...
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The role of myristoylation in the membrane association of the Lassa virus matrix protein Z
... and Lassa virus infection ...the virus particle ...In Lassa virus-infected cells, Z is mainly localized at the inner surface of the plasma ...of Lassa virus interacts with ...
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Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction
... A mong the arenaviruses, Lassa virus (LASV) represents the most prevalent human pathogen, with several hundred thousand infections per year (1). Carried by persistent infection of the reservoir rodent host ...
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Genetic Diversity among Lassa Virus Strains
... strains (36 strains) of lineage IV. Strain 807875 (Table 1), for which the site of origin was undetermined, was omitted from the analysis. A corresponding pairwise geographic-distance matrix was prepared by calculating ...
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Replicon System for Lassa Virus
... of Lassa virus MGs. Lassa virus minigenomes (MGs) were constructed on the basis of vector pX12 ⌬ T (7) (kindly provided by Ursula Buchholz and Karl-Klaus Conzelmann), which contains a multiple ...
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