leptin, leptin-receptor
Increased leptin/leptin receptor pathway affects systemic and airway inflammation in COPD former smokers
... that leptin is involved in local and systemic inflammation of smoker and former smoker COPD patients, matched for age, gender, pulmonary function, and BMI and body ...the leptin/leptin ...
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Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia
... of leptin and leptin receptor genes in pediatric popula- ...of leptin and leptin receptor genes with overweight and the intensity of chemotherapy and/or ...both leptin and ...
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Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica Infection
... that leptin receptor presence on the epithelial barrier was critical for ...of leptin receptor on epithelial cells was critical for defense against ...including leptin (19–22), ...
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Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population
... [4]. Leptin exerts its physiological effect by binding to leptin receptor, a single transmembrane protein which belongs to class I cytokine receptor ...Upon leptin binding to its ...
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Leptin levels and leptin receptor polymorphism frequency in healthy populations
... of leptin have been shown to cor- relate with obesity [2], a known risk factor for postmenopausal breast cancer ...that leptin stimulates the proliferation of normal and malignant breast epithelial cells ...
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A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
... children. Leptin is a hormone produced by adipocytes that inhibits food intake, influences the immune system, and is suppressed in mal- nourished ...diminished leptin function may increase susceptibility to ...
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PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction
... in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including ...insulin receptor (InsR) downstream of leptin ...in leptin ...
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Evaluation of the leptin receptor in human spermatozoa
... The leptin receptor (ObR) is a type I cytokine receptor family protein that has a significant amino acid sequence identity with gp130, GM-CSF receptor, and the LIF ...the leptin ...
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Differential Expression of Leptin and Leptin Receptor mRNA in Obese and Non Obese Women across the Menstrual Cycle Title
... that leptin, the product of the obese (ob) gene, which is synthesized and secreted ex- clusively by adipose tissue, provides a signal regulating the total mass of body fat ...serum leptin levels are ...
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Leptin and the leptin receptor : Molecular and genetic studies
... that leptin levels increase throughout puberty, in response to increasing fat mass (Clayton et ...boys, leptin appears to increase until Tanner stage 2 of puberty when the testosterone surge occurs, ...
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Intermittent Hypoxia Affects Leptin and Leptin Receptor Signaling in the Rat Carotid Body
... both leptin and the Ob-R’s are altered during IH during the time plasma levels of leptin are elevated by ...that leptin, either through an autocrine/paracrine mechanism or from other sources that ...
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Leptin interferes with 3',5'-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells
... the leptin receptor in the endo- crine pancreas [27], the ovary [8] and the placenta ...expression, leptin can directly modulate the activity of these glands. Leptin has been shown to inhibit ...
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Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming
... that leptin levels in the umbilical cord blood correlated positively with newborn’s birth weight, but on the fifth day, the association between cord blood leptin and weight was lost ...the leptin ...
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Leptin promotes melanoma tumor growth in mice related to increasing circulating endothelial progenitor cells numbers and plasma NO production
... Methods: 2 × 10 6 B16F10 melanoma cells were injected to thirty two C57BL6 mice subcutaneously. The mice were randomly divided into 4 groups (n = 8) in 8th day. Two groups were received twice daily intraperitoneal(i.p) ...
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Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants
... of leptin and sOB-R were kept at -70°C until measurement. Plasma leptin and sOB-R were measured using the commercial enzyme linked immunoassay kits from the same manufacturer (Diagnostic Systems ...
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Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation
... of leptin, which was partially sup- pressed in the ASH fed animals ...of leptin resistance in obesity has been attributed to the downregulation of cel- lular responses to leptin ...higher ...
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Modeling of Sic Power Semiconductor Devices For Switching Converter Applications
... that leptin failed to promote growth of colon cancer xenografts in nude mice and did not increase intestinal tumorigenesis in Apc Min/+ mice 5 ...in leptin-deficient tumors, as well as a dramatic inhibition ...
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Intermittent Hypoxia Alters Metabolic and Cardiovascular Neural Pathways
... When leptin was first discovered in 1994, it was believed the satiety- inducing hormone would act to resolve positive body energy balance syndromes like ...of leptin to obese mice have varying sensitivities ...
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Complementary genetic and functional analyses of genes involved in adiposity
... influence leptin levels, with one example being that leptin levels fluctuate during the menstrual cycle (Shimizu et al, ...the leptin receptor ...
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Phocid seal leptin : tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution
... hormone leptin is a key signalling molecule in many pathways that control physiological ...Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in ...
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