Leptin receptor (OB-R)
Intermittent Hypoxia Affects Leptin and Leptin Receptor Signaling in the Rat Carotid Body
... both leptin and the Ob-R’s are altered during IH during the time plasma levels of leptin are elevated by ...that leptin, either through an autocrine/paracrine mechanism or from other sources ...
202
Evaluation of the leptin receptor in human spermatozoa
... for leptin receptor detection To assess leptin receptor expression in sperm and PBMCs, 10 6 cells were diluted in 200 μl of PBS contain- ing 1% BSA and left for 30 minutes at room tempera- ...
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Leptin and the leptin receptor : Molecular and genetic studies
... of leptin on the human endometrium were ...for leptin within the human endometrium was the identification of leptin receptor iso form ...the leptin receptor were present in ...
243
Leptin Receptor Mutation Results in Defective Neutrophil Recruitment to the Colon during Entamoeba histolytica Infection
... Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been ...defense. Leptin expression was increased in the cecum by ...that leptin could serve as ...
8
Leptin levels and leptin receptor polymorphism frequency in healthy populations
... the ob gene, is a biologically active polypeptide (16 kDa) primarily produced in adipose tis- sue ...of leptin have been shown to cor- relate with obesity [2], a known risk factor for postmenopausal breast ...
6
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children
... children. Leptin is a hormone produced by adipocytes that inhibits food intake, influences the immune system, and is suppressed in mal- nourished ...diminished leptin function may increase susceptibility to ...
9
Glucocorticoid induced leucine zipper (GILZ) is involved in glucocorticoid induced and mineralocorticoid induced leptin production by osteoarthritis synovial fibroblasts
... GILZ, leptin and Ob- R expressions is also GR-dependent; indeed, their induc- tion remains unchanged in the presence of specific MR inhibitors, whereas it is abolished in the presence of spe- cific ...
15
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production
... obscure. Leptin, a 16-kDa protein encoded by the ob gene, is predominantly produced by adipocytes ...where Ob-Rs are highly expressed [39, 40]. Later, Ob-Rs were found to have a wide ...
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Phocid seal leptin : tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution
... hormone leptin is a key signalling molecule in many pathways that control physiological ...Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in ...
9
In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen activated protein kinase and phosphatidylinositol 3 kinase signaling pathways
... mouse leptin receptor (182 bp) 5 ⬘ - AGGCGCAGCCTGTATTGTCC-3 ⬘ and 5 ⬘ -CACGTTGGTGGCGAGT- CAAG-3 ⬘ ; and  -actin (198 bp) 5 ⬘ -AAGAGAGGTATCCTGACCCT-3 ⬘ and 5 ⬘ -TACATGGCTGGGTGTTGAA-3 ⬘ ...
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Leptin inhibits 4 aminopyridine– and pentylenetetrazole induced seizures and AMPAR mediated synaptic transmission in rodents
... Leptin receptor expression has been reported in the hippo- campus and neocortex (10–12), but its functional role is poorly ...studies leptin suppressed epileptiform-like bursting and elevations in ...
10
Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?
... insulin receptor, the epidermal growth factor receptor and the interleukin 2 receptor ...factor receptor [61], mitogenesis [66], agglutination of red blood cells [48], activation of platelets ...
7
Leptin constrains acetylcholine induced insulin secretion from pancreatic islets of ob/ob mice
... of ob/ob mice and fa/fa rats (animals with a deficiency in leptin or leptin resistance sec- ondary to a mutation in the leptin receptor) is an enhanced in- sulin secretion ...
7
Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming
... that leptin levels in the umbilical cord blood correlated positively with newborn’s birth weight, but on the fifth day, the association between cord blood leptin and weight was lost ...the leptin ...
6
Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells
... [20]. Leptin receptors are localized on adipose tissue cells [21]. Leptin binding to the leptin receptor stimu- lates stem cell proliferation [20], differentiation [22,23] and cytokine ...
13
Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation
... of leptin, which was partially sup- pressed in the ASH fed animals ...of leptin resistance in obesity has been attributed to the downregulation of cel- lular responses to leptin ...higher ...
18
Complementary genetic and functional analyses of genes involved in adiposity
... influence leptin levels, with one example being that leptin levels fluctuate during the menstrual cycle (Shimizu et al, ...the leptin receptor ...
225
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
... that leptin, an adipocyte-secreted hormone belonging to the helical cytokine family, significantly influences immune and autoimmune ...of leptin effects protects SJL/J mice from proteolipid protein peptide ...
10
Effect of Plasma-leptin on Cardiac Disorders with Type 2 Diabetes-patients
... plasma leptin and soluble leptin receptor (sOb-R) levels, and heart rate variability (HRV) ...0.001, r = 0.262; p = 0.008) and saturated fatty acid (r = ...0.001, r = ...
12
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
... of leptin on seba- ceous gland biology. Leptin, a peptide hormone secret- ed by adipocytes, reduces food intake, enhances energy expenditure, and increases insulin sensitivity through its hypothalamic ...
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