leucine-zipper
Homeobox leucine zipper proteins and cotton improvement
... associated leucine zipper proteins (HD-Zip) constitute a family of transcription factors that are characterized by the presence of a DNA- binding domain closely linked with leucine zipper ...
6
Mutational analysis of the leucine zipper motif in the Newcastle disease virus fusion protein.
... multiple leucine substitutions, suggested that only the nonpolar side of the helix involving the conserved leucine residues is specifically required for the func- tion of the ...multiple leucine ...
10
Amino Acid Substitutions within the Leucine Zipper Domain of the Murine Coronavirus Spike Protein Cause Defects in Oligomerization and the Ability To Induce Cell-to-Cell Fusion
... heptadic leucine residues are pivotal in contributing to the oligomeric function of a leucine zipper domain, we exam- ined whether the loss of fusion is associated with any changes in the ...
8
A Conserved Leucine Zipper Motif in Gammaherpesvirus ORF52 Is Critical for Distinct Microtubule Rearrangements
... a leucine. Although not perfectly conserved, a third leucine is present in this relative position in most gamma- herpesvirus ORF52 orthologs, and when it is not present, the residue at this position is ...
18
A Leucine Zipper Motif of a Tegument Protein Triggers Final Envelopment of Human Cytomegalovirus
... The present study demonstrated by using the affinity-purified monospecific antibody pAbUL71 that pUL71 has the ability to form oligomers. These results were confirmed by gel filtration followed by single-particle ...
13
Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander?
... Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids has been reported to be essential for their anti-inflammatory actions. At the same time, GILZ is actively downregulated under ...
12
C-Terminal HIV-1 Transframe p6* Tetrapeptide Blocks Enhanced Gag Cleavage Incurred by Leucine Zipper Replacement of a Deleted p6* Domain
... FIG 2 The presence of four C-terminal p6* residues counteracts the leucine zipper enhancement effect on Gag processing. (A) Schematic representations of HIV-1 Gag and Gag-Pol expression constructs. HIV-1 ...
15
A Putative Leucine Zipper within the Herpes Simplex Virus Type 1 UL6 Protein Is Required for Portal Ring Formation
... putative leucine zipper domain was deleted, was defective in the assembly of the portal ...the leucine zipper resulted in viral progeny unable to cleave and package the ...dicted ...
10
Investigation of the Multimerization Region of the Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Protein K-bZIP: the Proposed Leucine Zipper Region Encodes a Multimerization Domain with an Unusual Structure
... of leucine residues within the carboxy-terminal half of the protein and termed it a leucine zipper (14, 26, 40, ...putative zipper domain were generated and are shown schematically ...proposed ...
6
Identification and expression of ventrally associated leucine zipper (VAL) in Xenopus embryo
... In vertebrate embryos, BMP signaling is essential for develop- ment of the ventral tissues, such as the blood island mesoderm (Dale et al., 1992; Jones et al., 1992; Maéno et al., 1994; Fainsod et al., 1994; Maéno et ...
6
The Homer family proteins
... and leucine zipper motifs of long Homer forms; ER, endoplasmic reticulum; EVH1, the amino-terminal EVH1 domain of Homer; G, G protein; GKAP, guanylate kinase-associated protein; GRIP, glutamate receptor ...
12
Molecular signatures of T cell inhibition in HIV 1 infection
... cell–mediated pathology during early systemic murine LCMV infection, indicating that immunopathological side effects might arise when interfering with the PD-1 path- way [19,20,26]. Accumulating evidence shows that HIV- ...
14
Human Cytomegalovirus UL84 Oligomerization and Heterodimerization Domains Act as Transdominant Inhibitors of oriLyt-Dependent DNA Replication: Evidence that IE2-UL84 and UL84-UL84 Interactions Are Required for Lytic DNA Replication
... UL84 leucine zipper motif, indicating leucine residues 1 (aa 114), 2 (aa 121), 3 (aa 128), and 4 (aa 135) that comprise the putative leucine ...UL84 leucine zipper mutants. ...
12
An overview of the basic helix loop helix proteins
... additional zipper domain that is carboxy-terminal to the HLH ...additional leucine zipper domain; Figure 1d-f) reveal that the presence or absence of ...
6
Molecular signatures of T cell inhibition in HIV 1 infection
... cell–mediated pathology during early systemic murine LCMV infection, indicating that immunopathological side effects might arise when interfering with the PD-1 path- way [19,20,26]. Accumulating evidence shows that HIV- ...
14
Both Neutralization Resistance and High Infectivity Phenotypes Are Caused by Mutations of Interacting Residues in the Human Immunodeficiency Virus Type 1 gp41 Leucine Zipper and the gp120 Receptor- and Coreceptor-Binding Domains
... The HIV-1 LZ forms an oligomeric, probably trimeric, coiled coil which maintains the complete envelope complex in an oligomeric state. LZs are amphipathic alpha-helical struc- tures in which leucine, isoleucine, ...
7
Homomeric interactions between transmembrane proteins of Moloney murine leukemia virus.
... potential leucine zipper motif, but it is not clear whether the motif is the essen- tial feature for the ...the leucine zipper-like motif, were capable of interacting with either the wild-type ...
5
Original Article High levels of TFEC expression associated with aggressive clinical features in ovarian cancer
... Abstract: Transcription factor EC (TFEC), a divergent member of the microphtalmia (MiT) family of basic helix-loop- helix leucine zipper transcription factors, appears to inhibit transcription rather than ...
11
Sequence and structural analysis of BTB domain proteins
... We searched the Ensembl and Uniprot databases for BTB proteins [32,33]. In order to effectively eliminate redundant sequences and partial fragments, and to reduce sampling bias due to uneven database representation, we ...
18
Oxidative stress in sepsis: a redox redux
... region–leucine zipper transcription fac- tor, is a key regulator of the cellular redox state in sepsis, in part by regulating levels of intracellular glutathione, a key antioxi- dant ...
5