Leukemic Stem Cells
Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones
... hematopoietic stem cell disorders in which both failure to differentiate and increased proliferation potential in the stem cell compartment result in accumulation of non-functional cells termed ...
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BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment
... pathways. Myc, as a transcription factor, is challenging to target directly, given the lack of pockets that could be targeted directly with small molecules, and hence much effort has been focused on indirect targeting ...
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Chronic Myelocytic Leukemia: ORIGIN OF SOME LYMPHOCYTES FROM LEUKEMIC STEM CELLS
... same stem cell origin as the leukemic myeloid ...the leukemic myelogenous cells displayed only one isoenzyme type, consistent with their clonal ...of cells with undoubted thymus-derived ...
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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
... (JAK)/STAT pathway, especially STAT3, has been an attractive therapeutic target in many cancer stem cell models, but has been hard to selectively inhibit therapeutically. AZD9150 is a genera- tion 2.5 antisense ...
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PP2A activating drugs selectively eradicate TKI resistant chronic myeloid leukemic stem cells
... The notion that TKIs do not kill quiescent CML HSCs (5) because BCR-ABL1 activity is dispensable for their survival (7, 8) suggests that other aberrantly regulated signals control leukemic stem cell ...
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AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells
... effector cells can be too strong to lead to a cytokine storm and even to death ...T cells, this approach is less efficient against AML LSCs but more convenient and controllable in the clinical ...
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Original Article Tim-3 as a leukemia stem cell specific marker expressing on bone marrow mononuclear cells is a factor for prognosis evaluation in patients with acute myelogenous leukemia
... in leukemic stem cells (LSCs) of acute myelogenous leukemia (AML), however, the alterations of Tim-3, as well as its marker and prognostic significance has yet to be evaluated in patients with ...
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Phase I clinical study of RG7356, an anti-CD44 humanized antibody, in patients with acute myeloid leukemia
... initiating cells, colony forming unit–granulocyte macrophages, and leukemic cells ...of leukemic stem cells (LSC) to the stroma in the BM ...
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Curcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression
... malignant cells, silencing of OPN leads to elevation of sensitivity towards chemotherapeutic agents and attenuates cancer cells migration and ...on leukemic stem cells (LSCs) colony ...
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Mechanisms of chemoresistance in cancer stem cells
... tumor-initiating cells in acute myelogenous leukemia (AML) ...these leukemic initiating cells was based on differential ex- pression of cell surface markers CD34 and CD38 where only CD34 + /CD38 - ...
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Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells
... T cells could cross react with tumor cells, another possibility is that the alloreactive responses activate T cells specific for tumor associated ...T cells reac- tive with Wilms tumor-1 (WT1) ...
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A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications
... of leukemic cell lines to suspen- sions obtained from ovarian cortical strip dissociation ...few leukemic cells were retrieved during follicle pickup, they showed that three washes were sufficient to ...
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Marrow Cell Egress THE CENTRAL INTERACTION OF BARRIER PORE SIZE AND CELL MATURATION
... attractant. Immature granulocytes would not exit through a restrictive barrier even after protracted periods and were not responsive to chemoattractants. Intermediate-aged granulocytes showed a slight ability to respond ...
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Ebinger, Sarah (2018): Characterization of dormant and drug resistant stem cells using xenograft mouse models of patient-derived acute leukemia cells. Dissertation, LMU München: Fakultät für Biologie
... these cells for a myeloid origin by myeloperoxidase activity, or the presence of Auer rods (De Kouchkovsky and Abdul-Hay, ...hematological cells and eventually to bone marrow ...allogeneic stem cell ...
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Modulatory Effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Proliferation and Ultrastructural Changes in K562 Leukemic Cells
... K562 cells in both normal culture medium with 10% FBS and specialized culture medium without ...of leukemic cells ...K562 cells were quantified using 3-(4, 5-Dimethylthiazol- ...
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Cytotoxicity of Metoprolol on Leukemic Cells in Vitro
... As is shown in figure 1, metoprolol decreased viability of U937 cells in every three time periods. However, these cytotoxic effects were only statistically significant after 48 and 72 hours of treatment. After 48 ...
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Persistent donor derived Vδ4 T cell clones may improve survival for recurrent T cell acute lymphoblastic leukemia after HSCT and DLI
... the leukemic clone we identified at the initial time of disease and by monitoring the TCR repertoire in this case, the monoclonally expanded TCR Vδ5 subfamily with the Vδ5-Dδ2-Jδ1 rearrangement sequence was ...
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Expression of Endogenous Retroviral Genes in Leukemic Guinea Pig Cells
... cDNA prepared with oligodT as primer hybridized to the RNA of L2C leukemic lymphoblasts, leukemic spleen, BUdR-induced cells, and 70S vRNA, but did not hybridize appreciably to the RNA o[r] ...
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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... tumor cells be- come small and are involved in the metastasis and growth of prostate cancers or ovarian cancers [4, ...tumor cells. Additionally, in breast cancer, tumor cells release inflammatory ...
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Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia
... germ cells (dashed line, n = 6) or unsorted germ cells (solid line, n = 6) from C1498-inoculated GFP mice into seminiferous ...germ cells developed terminal signs of leukemia within 25 ...
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