Lewy body disease
Original Article Limbic Lobe Microvacuolation is Minimal in Alzheimer’s Disease in the Absence of Concurrent Lewy Body Disease
... Abstract: Microvacuolation is relatively common in the limbic lobe in Lewy body disease (LBD). Similar pathology has also been reported in Alzheimer's disease (AD). Almost all of the studies ...
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Characteristics of facial expression recognition ability in patients with Lewy body disease
... with Lewy body disease, the aim of this study is to examine points to facilitate smooth communication between caregivers and patients with the disease whose cognitive function has ...with ...
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Original Article Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease
... In Lewy body disease, Lewy pathology (LP: the accumulation of α-synuclein in neuronal perikarya and pro- cesses as Lewy bodies and Lewy neurites and dots, respectively) is ...
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Case report of Lewy body disease mimicking Creutzfeldt-Jakob disease in a 44-year-old man
... Creutzfeldt-Jakob disease was first suspected in this patient with no previous medical history, who developed acute and rapid cognitive impairment, L-dopa-non-responsive parkinsonism, and ...numerous Lewy ...
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A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
... with Lewy body disease, and compared its levels with re- gard to the presence of dementia ...(i.e., Lewy body demen- tia, LBD) or the absence of dementia ...Parkinson’s disease, ...
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The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis
... of Lewy body disease have found that the earliest sites of involvement are the olfactory bulb, the dorsal motor nucleus of the vagal nerve, the peripheral autonomic nervous system, including the ...
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Compensatory shifts in visual perception are associated with hallucinations in Lewy body disorders
... of Lewy body and other ...in Lewy body disease, have similar content to spontaneous hallucinations, and respond to cholinesterase inhibitors in the same ...with Lewy body ...
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New α- and γ-synuclein immunopathological lesions in human brain
... Another member of the synuclein family - γ-synuclein (γ-syn) is also aggregation-prone protein which forms intracellular inclusions. γ-Syn is a component of atypical inclusion bodies in human NDDs [7-11]. Furthermore, ...
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Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test
... of Lewy body dis- ...limbic Lewy pathology) and the twelve with DLBD (includes added cortical ...and Lewy pathology in brainstem and limbic regions, without widespread cortical involvement, ...
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Examining the mechanisms that link β-amyloid and α-synuclein pathologies
... versus Lewy bodies has historically been used to distinguish between AD and the dementing forms of Lewy body ...cant Lewy body pathology in addition to plaques and tangles ...the ...
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Computational modeling reveals multiple abnormalities of myocardial noradrenergic function in Lewy body diseases
... with Lewy body diseases (7 PAF, 6 PD with orthostatic hypotension, 64 ± 4 years, 9 men) (28, 38) and (b) post- mortem studies of apical myocardial catechols in 23 control subjects and 8 patients with ...
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ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
... α-synuclein-positive Lewy body inclusions ...of Lewy body disease cases with the coexisting age-related Azheimer-type pathologies ...
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Everyday conversation in dementia: a review of the literature to inform research and practice
... Alzheimer’s disease, vascular dementia and Lewy body dementia, or where due to the nature of the difficulties described memory problems were a central feature of the ...Alzheimer’s disease, ...
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Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
... Parkinson’s Disease Society Brain Bank Criteria [9]; 3) controls were drawn from the same population as cases; 4) controls were healthy or had no history of neurological disease; 5) RBD symptoms in controls ...
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Clinical prevalence of Lewy body dementia
... Our study identified clinical prevalence rates of DLB and PDD in a case series considerably lower than that reported by clinical epidemiological cohorts and neuropathological studies. Importantly, we observed significant ...
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Dementias Caused by Persistent Pathogens and the Protective Role of HLA Against them
... Alzheimer’s disease, vascular dementia, frontotemporal dementia, Lewy body dementia, and prion dementia in an effort to contextualize the role of persistent pathogens across the various dementia ...
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Dementia with Lewy bodies: an update and outlook
... region linking with DLB. This may impact on the gene expression and distribution of LB pathology in the brain. Multiple studies dissecting the genetic component of DLB have been published to date (for a comprehensive ...
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Biomarkers for the diagnosis of Alzheimer’s disease, dementia Lewy body, frontotemporal dementia and vascular dementia
... discovery of most known biomarkers specific to dementia. The vast majority of biomarkers are only obtained through lumbar punctures. The results that come from these methods are heavily dependent on the age and phys- ...
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Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story
... develop disease- modifying treatments for these conditions, and, despite many promising new therapies in the pipe- line, 12 several of these have failed to show any sig- nificant benefit and/or are plagued by ...
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Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?
... growing body of evi- dence supporting neuroinflammation as an important player in the pathogenesis of AD [79, ...Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT), failed to show improvement in ...
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