Linkage Disequilibrium Mapping
Joint Linkage and Linkage Disequilibrium Mapping of Quantitative Trait Loci in Natural Populations
... scale mapping of QTL affecting a quantitative trait in a natural population on the basis of a joint linkage and linkage disequilibrium mapping strategy proposed by Wu and Zeng ...
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Joint Linkage and Linkage Disequilibrium Mapping in Natural Populations
... current linkage analysis and linkage disequilibrium-based mapping the- ory to simultaneously estimate genetic map distances and population genetic associations of markers using random samples ...
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A Haplotype-Based Algorithm for Multilocus Linkage Disequilibrium Mapping of Quantitative Trait Loci With Epistasis
... age disequilibrium are ...to linkage disequilibrium mapping and will likely make our method more attractive to real-world ...(no disequilibrium), and that the two QTL interact at both ...
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Linkage Disequilibrium Mapping of Yield and Yield Stability in Modern Spring Barley Cultivars
... was applied any more. The differences in predictions from defined by Jaccard coefficients and average linkage as both models illustrate the necessity of accounting for correla- clustering algorithm produced a ...
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Fine Mapping of a Quantitative Trait Locus for Twinning Rate Using Combined Linkage and Linkage Disequilibrium Mapping
... ried alleles [3 1] at CSSM22 and ILSTS66 resulted in for linkage analysis. The LA profile of Figure 4 gives a the likelihood peak in this bracket. sharper peak than the linkage analysis of Lien et al. ...
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Linkage Disequilibrium Mapping of Arabidopsis CRY2 Flowering Time Alleles
... identified, linkage disequilibrium the associations that show significantly earlier flowering mapping suggests that the locus responsible is localized for accessions containing HAP ...
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Fine scale linkage disequilibrium mapping: a comparison of coalescent based and haplotype clustering based methods
... various linkage-disequilibrium (LD) fine-mapping methods, two broad classes have received considerable development recently: those based on coalescent theory and those based on haplotype ...
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Optimal Designs for Linkage Disequilibrium Mapping and Candidate Gene Association Tests in Livestock Populations
... The QTL effect was effectively biallelic, inasmuch as numer- QTL variance (proportion of 0.10 0.30 ous QTL alleles were initially simulated, but a nonzero effect genetic variance) was assigned to only a single allele. At ...
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A survey of data mining methods for linkage disequilibrium mapping
... a disequilibrium test is performed on each of them to test if there is a small set of subtrees with relatively high proportions of disease-associated chromosomes, suggesting shared genetic history for those and a ...
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Linkage Disequilibrium and the Mapping of Human Disease Genes
... Family-based linkage disequilibrium mapping using SNP markers is expected to be a major route to the identification of susceptibility alleles for complex ...in linkage disequilibrium ...
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Detecting Linkage Disequilibrium in Bacterial Populations
... values. The values expected if the distribution was normal (2) and those observed (s) diverge at both extremes of the distribution, although for testing the hypothe- sis of linkage equilibrium only the positive ...
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Linkage Disequilibrium as a Signature of Selective Sweeps
... showed that a position on a chromosome where a recent In this study, we propose a new composite-likelihood fixation of a beneficial mutation occurred can be identi- method for detecting signatures of selection that ...
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Linkage Disequilibrium Under Recurrent Bottlenecks
... ABSTRACT To model deviations from selectively neutral genetic variation caused by different forms of selection, it is necessary to fi rst understand patterns of neutral variation. Best understood is neutral genetic ...
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One Hundred Years of Linkage Disequilibrium
... of linkage disequilib- rium (LD) can be dated back to 1918, 10 years after the Hardy–Weinberg law introduced population genetics for a single ...of linkage and recombina- ...
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A Scan for Linkage Disequilibrium Across the Human Genome
... Linkage disequilibrium (LD), the tendency for alleles of linked loci to co-occur nonrandomly on chromosomal haplotypes, is an increasingly useful phenomenon for (1) revealing historic perturbation of ...
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Characterizing Linkage Disequilibrium in Pig Populations
... fine mapping of quantitative trait loci and marker assisted selection ...QTL mapping, LD plays a fundamental role in QTL mapping because choice of appropriate marker spacing and resulting QTL ...
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Linkage disequilibrium of single nucleotide polymorphism data: how sampling methods affect estimates of linkage disequilibrium
... BMC Proceedings Proceedings Linkage disequilibrium of single nucleotide polymorphism data how sampling methods affect estimates of linkage disequilibrium Qimei He*1 and Bradley J Willcox2,3 Addresses[.] ...
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Linkage Disequilibrium Testing When Linkage Phase Is Unknown
... Our simulation results illustrate that when linkage phase is unknown, departures from HWE can have dra- matic effects on the commonly used likelihood-ratio statistic for testing LD. Gross departures from HWE, ...
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Linkage disequilibrium in growing and stable populations.
... Extensive simulations show that there is a substantial probability of obtaining significant nonrandom associations between closely or completely linked polymorphic neutra[r] ...
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Simultaneous Fine Mapping of Multiple Closely Linked Quantitative Trait Loci Using Combined Linkage Disequilibrium and Linkage With a General Pedigree
... for linkage mapping by H aley and K nott (1992) and M artinez and C urnow ...interval mapping and multiple re- gression on marker genotypes for mapping multiple QTL ...
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