liquid biopsy
Liquid Biopsy in Liquid Tumors
... The liquid biopsy has the potential to achieve this ...sample. Liquid biopsy has been par- ticularly studied in solid tumors, specially of the epitelial origin, such as a pan- creatic ...
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Multi-modal liquid biopsy platform for cancer screening: screening both cancer-associated rare cells and cancer cell-derived vesicles on the fabric filters for a reliable liquid biopsy analysis
... Circulating tumor cells (CTCs) and exosomes have emerged as potential liquid biopsy biomarkers for deter- mining the histological features, aggressiveness and metastatic potential of the tumor [11, 12]. ...
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The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer
... NGS-based liquid biopsy has appeared to be a valu- able approach to decipher the spatiotemporal tumor evolution of lung ...based liquid biopsy might potentially contribute to piecing together ...
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Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy
... in liquid biopsy, reliable quantitative detection results must be ...to liquid biopsy analysis for minimizing the effect of non-specific binding in future ...
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Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy
... “Liquid biopsy” or the mutational analysis of ctTNA in accessible body fluids by targeted next generation sequencing (NGS) is commonly applied in patients with systemic cancer and the resulting ...
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Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations
... A liquid biopsy as a simple and non-invasive tool enables scientists to trace all solid tumor genetic and epigenetic alterations through a simple blood ...of liquid biopsy in diagnosis, ...
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The applications of liquid biopsy in resistance surveillance of anaplastic lymphoma kinase inhibitor
... Abstract: With the clinical promotion of precision medicine and individualized medical care, molecular targeted medicine has been used to treat non-small cell lung cancer (NSCLC) patients and proved to be significantly ...
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Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer
... Extracellular vesicles (EVs) secreted from cancer cells have potential for generating cancer biomarker signatures. Fibronectin (FN) was selected as a biomarker candidate, due to the presence in surface on EVs secreted ...
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Next-generation sequencing in liquid biopsy: cancer screening and early detection
... ctDNA is highly fragmented, ranging from 100 to 10, 000 bp. It is challenging to isolate ctDNA from the blood for quantitation since the small fragments are easy to lose or degrade [88]. Although the concentration of ...
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An automated high throughput solution for DNA extraction and bisulfite conversion from high volume liquid biopsy specimens: sample preparation for epigenetic analysis
... liquid biopsy samples was performed in 24-well plates (hitplate25, HJ Bioanalytik). The binding of DNA to the magnetic particles in the extraction step was performed in parallel on four heated shakers ...
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Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis
... EV proteins, glycomics can be used to study EV surface glycans or glycoproteins such as prostatic acid phosphatase (PAP) and PSA to improve PCa diagnosis [111, 112]. For example, N-linked glycan of exosomes derived from ...
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Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy
... The detection and characterization of CTCs will provide new insights into the mechanism of cancer metastasis and into the clinical management of cancers. However, because of the low quantity of CTCs detected by the ...
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Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model
... uid biopsy [7], also known as fluid biopsy or fluid phase biopsy has potential in analyzing the genomic landscape of patients with cancer, supervising treatment responses, monitoring minimal residual ...
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<p>Update on liquid biopsy in clinical management of non-small cell lung cancer</p>
... Tissue biopsy was regarded as the “ standard procedure ” for molecular detection and was indispensable in decision-making concerning treat- ment for advanced NSCLC patients before ...12 Liquid ...
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EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors
... tumor biopsy tissue may not reflect the overall tumor mutational features due to high tumor burden and ...as liquid biopsy has provided a non-invasive option ...
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Towards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy
... rely on the selective chemical binding of 5hmC to enrich for 5hmC-containing DNA fragments. These fragments are then sequenced to obtain genome-wide information of 5hmC [53, 59]. Because the size of these chemically ...
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Limits and potential of targeted sequencing analysis of liquid biopsy in patients with lung and colon carcinoma
... on liquid biopsy for patients with non-small-cell lung carcinoma (NSCLC) has been approved in Europe based on the results of the IFUM trial that showed an acceptable sensitivity and specificity of this ...
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A consensus on liquid biopsy from the 2016 Chinese Lung Cancer Summit expert panel
... of liquid biopsy in clinical applications, clini- cians must be cautioned that these novel techniques are still in their ...technique, liquid biopsy is playing an increasingly important role ...
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THE INNOVATIONS, ADVANCES AND OUTLOOKS OF LIQUID BIOPSY IN ONCOLOGY: A LITERATURE REVIEW
... Tumor cells can release DNA fragments into the circulation through apoptosis, necrosis and active secretion, but the former is the most common form of this release. 3,5,7,8 Tumor cell DNA (ctDNA) is another promising ...
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Emerging molecular technologies in renal cell carcinoma: liquid biopsy
... Identification of specific mutations or a set of mutations associate with an aggressive tumor behavior such as SETD2, PBRM1, and BAP1 could be relevant to clinicians considering using liquid biopsy to guide ...
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